A platform to map the mind–mitochondria connection and the hallmarks of psychobiology: the MiSBIE study

Kelly, Catherine; Trumpff, Caroline; Acosta, Carlos; Assuras, Stephanie; Baker, Jack; Basarrate, Sophia; Behnke, Alexander; Bo, Ke; Bobba-Alves, Natalia; Champagne, Frances A.; Conklin, Quinn; Cross, Marissa; De Jager, Philip; Engelstad, Kris; Epel, Elissa; Franklin, Soah G.; Hirano, Michio; Huang, Qiuhan; Junker, Alex; Juster, Robert-Paul; Kapri, Darshana; Kirschbaum, Clemens; Kurade, Mangesh; Lauriola, Vincenzo; Li, Shufang; Liu, Cynthia C.; Liu, Grace; McEwen, Bruce; McGill, Marlon A.; McIntyre, Kathleen; Monzel, Anna S.; Michelson, Jeremy; Prather, Aric A.; Puterman, Eli; Rosales, Xiomara Q.; Shapiro, Peter A.; Shire, David; Slavich, George M.; Sloan, Richard P.; Smith, Janell L.M.; Spann, Marisa; Spicer, Julie; Sturm, Gabriel; Tepler, Sophia; de Schotten, Michel Thiebaut; Wager, Tor D.; Picard, Martin

doi:10.1016/j.tem.2024.08.006

Trends in Endocrinology & Metabolism

2024

DOI: 10.1016/j.tem.2024.08.006

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A platform to map the mind–mitochondria connection and the hallmarks of psychobiology: the MiSBIE study

Catherine Kelly,

Caroline Trumpff,

Carlos Acosta

et al.

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2024

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Cited by 1 publication

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The Energetic Stress Marker GDF15 is Induced by Acute Psychosocial Stress

Huang,

Monzel,

Rausser

et al. 2024

Preprint

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GDF15 (growth differentiation factor 15) is a marker of cellular energetic stress linked to physical-mental illness, aging, and mortality. However, questions remain about its dynamic properties and measurability in human biofluids other than blood. Here, we examine the natural dynamics and psychobiological regulation of plasma and saliva GDF15 in four human studies representing 4,749 samples from 188 individuals. We show that GDF15 protein is detectable in saliva (8% of plasma concentration), likely produced by salivary glands secretory duct cells. Plasma and saliva GDF15 levels are not correlated. Using a brief laboratory socio-evaluative stressor paradigm, we find that psychological stress increases plasma (+3.4-5.3%) and saliva GDF15 (+45%) with distinct kinetics, within minutes. Moreover, saliva GDF15 exhibits a robust awakening response, declining by ~42-92% within 30-45 minutes from its peak level at the time of waking up. Clinically, individuals with genetic mitochondrial OxPhos diseases show elevated baseline plasma and saliva GDF15, and post-stress GDF15 levels in both biofluids correlate with multi-system disease severity, exercise intolerance, and the subjective experience of fatigue. Taken together, our data establish the dynamic properties of saliva GDF15, reveal it as a stress-sensitive, and as a clinically relevant marker of mitochondrial diseases. These findings point to a shared psychobiological pathway integrating metabolic and mental stress.

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The Energetic Stress Marker GDF15 is Induced by Acute Psychosocial Stress

Huang,

Monzel,

Rausser

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

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A platform to map the mind–mitochondria connection and the hallmarks of psychobiology: the MiSBIE study

Cited by 1 publication

References 136 publications

The Energetic Stress Marker GDF15 is Induced by Acute Psychosocial Stress

The Energetic Stress Marker GDF15 is Induced by Acute Psychosocial Stress

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