A plethysmographic method for measuring systolic blood pressure in the intact rat

Byrom, F.B.; Wilson, Campbell

doi:10.1113/jphysiol.1938.sp003641

Cited by 164 publications

(32 citation statements)

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“…Control groups of both the weanling and adult rats had their renal arteries clamped at the same time. Two to three weeks later, blood pressure (1 mmHg-1333 mbar) was measured by a plethysmographic method from the tail under light ether anaesthesia (Byrom & Wilson, 1938). Blood pressure was measured thereafter every week for 7-9 weeks.…”

Section: Methodsmentioning

confidence: 99%

Importance of the sympathetic nervous system in the development of renal hypertension in the rat

Grewal¹,

Kaul²

1971

British J Pharmacology

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Summary1. Chemical sympathectomy with 6-hydroxydopamine (6-OHDA) prevented the development of renal hypertension in 80% of weanling male rats of the C.F. strain. 2. Adult male rats treated with 6-OHDA developed hypertension on bilateral clamping of the renal arteries. 3. Demedullation of the adrenal glands followed by 6-OHDA treatment in adult rats prevented the development of hypertension in 75% of them. 4. Weanling rats treated with 6-OHDA did not have any measurable catecholamines in their hearts up to 72-78 days after treatment. 5. Unlike the weanling rats, the hearts of adult rats (demedullated or with intact medulla) showed significant refilling (40-50%) of catecholamine stores 60 days after 6-OHDA treatment. 6. It is concluded that the functional sympathetic nervous system is important in the development of renal hypertension in the rat.

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Section: Methodsmentioning

confidence: 99%

Importance of the sympathetic nervous system in the development of renal hypertension in the rat

Grewal¹,

Kaul²

1971

British J Pharmacology

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“…Arterial pressure was measured in conscious animals using the tail-cuff method (Byrom & Wilson 1938), with an electrosphygmomanometer (Digital Pressure Meter LE 5000; Letica, S.A., Barcelona, Spain) before and after nephrectomy, and at the end of the five weeks of treatment. Systolic and diastolic values were converted into mean arterial pressure (MAP) [MAPΩ(2 diastolic pressure π systolic pressure)/ 3].…”

Section: Methodsmentioning

confidence: 99%

Beneficial Effects of Trandolapril in Uninephrectomized Spontaneously Hypertensive Rats: Role of Cyclooxygenase Pathway

López‐Hernández

Carrón

Montero

2002

Pharmacology & Toxicology

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Abstract:The antihypertensive efficacy of the angiotensin-converting enzyme inhibitor trandolapril was evaluated in uninephrectomized spontaneously hypertensive rats. After 5 weeks of treatment, blood pressure, cardiac and aortic mass, as well as the functional status of the aortic endothelium, and the role played by the cyclooxygenase pathway were investigated. In addition, the effect of a sub-antihypertensive dose of the calcium antagonist verapamil, in combination with trandolapril, was also investigated. As compared to placebo, trandolapril returned blood pressure and aortic lamina media cross sectional area to normotensive values, significantly reduced the heart-to-body weight, and improved the acetylcholine-induced relaxation of aortic rings. This latter effect is thought to be mediated by the elimination of a substance derived from the cyclooxygenase pathway. Verapamil, in single therapy, did not reduce blood pressure, or heart-to-body weight, increased aortic lamina media cross sectional area and impaired acetylcholine-induced relaxation. When combined with trandolapril in dual therapy, some of the beneficial effects of trandolapril remained, whereas others were counterbalanced by verapamil. In conclusion, trandolapril proved to be an effective therapeutic drug in this animal model of hypertension. Combination of trandolapril with a sub-antihypertensive dose of verapamil did not show any positive synergistic effect; on the contrary, it outweighed some of the beneficial effects of trandolapril.

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“…1 and 2 iuul is t'oiiBtrnctod as follows: The occluding cuff is identical with that described by Byrom and Wilson (1938). Since some difficulty may lie I'ncountered in making Jicat cyliiulrical sleeves out of thin sheet latex, some amplification of tlie original description is desirable.…”

Section: Methodsmentioning

confidence: 99%

An Optical Method for Measuring Systolic Blood‐pressure in the Intact Rat

1947

Aust J Exp Biol Med

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A plethysmographic method for measuring systolic blood pressure in the intact rat

Cited by 164 publications

References 1 publication

Importance of the sympathetic nervous system in the development of renal hypertension in the rat

Importance of the sympathetic nervous system in the development of renal hypertension in the rat

Beneficial Effects of Trandolapril in Uninephrectomized Spontaneously Hypertensive Rats: Role of Cyclooxygenase Pathway

An Optical Method for Measuring Systolic Blood‐pressure in the Intact Rat

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