A plug-and-play optical fiber SPR sensor for simultaneous measurement of glucose and cholesterol concentrations

Zheng, Wanlu; Zhang, Ya‐nan; Li, Li-ke; Li, Xuegang; Zhao, Yong

doi:10.1016/j.bios.2021.113798

Cited by 70 publications

(17 citation statements)

References 28 publications

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“…Plasmon modes that satisfy the phase matching condition are coupled with incident photons in the energy. This forms surface plasmon polaritons (SPPs) which will propagate along the upper surface of the metal layer 43 .…”

Section: Principle Of Configuring Plasmonic Resonance Spectral Charac...mentioning

confidence: 99%

“…The higher the dielectric constant of the dielectric layer, the larger the redshift range of the resonance dip. Although the dielectric layer can enhance the overlap integral of the electric field, thereby can improve the sensitivity, the dielectric layer also greatly increases the radiation loss of SPPs, and the FWHM is severely broadened 39,43,45 , as shown in Fig. 1(c).…”

Section: Principle Of Configuring Plasmonic Resonance Spectral Charac...mentioning

confidence: 99%

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Highly sensitive and stable probe refractometer based on configurable plasmonic resonance with nano-modified fiber core

Jing¹,

Liu²,

Jiang³

et al. 2023

OEA

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A dispersion model is developed to provide a generic tool for configuring plasmonic resonance spectral characteristics. The customized design of the resonance curve aiming at specific detection requirements can be achieved. According to the model, a probe-type nano-modified fiber optic configurable plasmonic resonance (NMF-CPR) sensor with tip hot spot enhancement is demonstrated for the measurement of the refractive index in the range of 1.3332-1.3432 corresponding to the low-concentration biomarker solution. The new-type sensing structure avoids excessive broadening and redshift of the resonance dip, which provides more possibilities for the surface modification of other functional nanomaterials. The tip hot spots in nanogaps between the Au layer and Au nanostars (AuNSs), the tip electric field enhancement of AuNSs, and the high carrier mobility of the WSe 2 layer synergistically and significantly enhance the sensitivity of the sensor. Experimental results show that the sensitivity and the figure of merit of the tip hot spot enhanced fiber NMF-CPR sensor can achieve up to 2995.70 nm/RIU and 25.04 RIU −1 , respectively, which are 1.68 times and 1.29 times higher than those of the conventional fiber plasmonic resonance sensor. The results achieve good agreements with numerical simulations, demonstrate a better level compared to similar reported studies, and verify the correctness of the dispersion model. The detection resolution of the sensor reaches up to 2.00×10 −5 RIU, which is obviously higher than that of the conventional side-polished fiber plasmonic resonance sensor. This indicates a high detection accuracy of the sensor. The dense Au layer effectively prevents the intermediate nanomaterials from shedding and chemical degradation, which enables the sensor with high stability. Furthermore, the terminal reflective sensing structure can be used as a practical probe and can allow a more convenient operation.

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Section: Principle Of Configuring Plasmonic Resonance Spectral Charac...mentioning

confidence: 99%

Section: Principle Of Configuring Plasmonic Resonance Spectral Charac...mentioning

confidence: 99%

Highly sensitive and stable probe refractometer based on configurable plasmonic resonance with nano-modified fiber core

Jing¹,

Liu²,

Jiang³

et al. 2023

OEA

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show abstract

“…Furthermore, the advantages and unique qualities of DTP-based fiber sensors compared with different types of sensing technology, such as ultra-compactness, mechanical flexibility, biocompatibility, and electromagnetic interference resistance, need to be clarified. We think that attention can be focused on applications of label-free biological sensing, the study of coating functionalization materials, the enhancement of sensing sensitivity, and demodulation algorithms of multi-parameter sensing [ 5 , 8 , 25 , 74 , 75 ]. The concept of “lab-on-fiber” also needs to be highlighted [ 76 ].…”

Section: Challenges and Opportunitiesmentioning

confidence: 99%

“…On the other hand, microfibers demonstrate excellent configurability into various microstructures, such as loops, junctions, coils, and couplers, due to their good flexibility and mechanical strength [ 3 ]. Researchers have reported various schemes of microfiber-based sensors, including micro-gratings, interferometers, micro-resonators, and surface plasmon resonance-based microfibers [ 5 ]. Although microfibers exhibit many outstanding characteristics, they have some inherent limitations, such as sensitivity and repeatability, that restrict their usefulness in sensing applications.…”

Section: Introductionmentioning

confidence: 99%

Ultrasensitive Optical Fiber Sensors Working at Dispersion Turning Point: Review

Peng

et al. 2023

Sensors

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Optical fiber sensors working at the dispersion turning point (DTP) have served as promising candidates for various sensing applications due to their ultrahigh sensitivity. In this review, recently developed ultrasensitive fiber sensors at the DTP, including fiber couplers, fiber gratings, and interferometers, are comprehensively analyzed. These three schemes are outlined in terms of operation principles, device structures, and sensing applications. We focus on sensitivity enhancement and optical transducers, we evaluate each sensing scheme based on the DTP principle, and we discuss relevant challenges, aiming to provide some clues for future research.

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“…The dual-parameter SPR biosensor was developed by Zheng et al based on the HPCF modified with an Au film and AuNPs. The developed sensor offers a fresh approach to dual-parameter measurement and broadens the scope of applications for optical fiber biosensors in the biomedical industry [ 146 ]. However, the low detection range reduces the practical value of dual-parameter sensors to a certain extent.…”

Section: Application Of 2d Nanomaterials In the Field Of Optical Fibe...mentioning

confidence: 99%

Advances in Novel Nanomaterial-Based Optical Fiber Biosensors—A Review

Singh

Wang

et al. 2022

Biosensors

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This article presents a concise summary of current advancements in novel nanomaterial-based optical fiber biosensors. The beneficial optical and biological properties of nanomaterials, such as nanoparticle size-dependent signal amplification, plasmon resonance, and charge-transfer capabilities, are widely used in biosensing applications. Due to the biocompatibility and bioreceptor combination, the nanomaterials enhance the sensitivity, limit of detection, specificity, and response time of sensing probes, as well as the signal-to-noise ratio of fiber optic biosensing platforms. This has established a practical method for improving the performance of fiber optic biosensors. With the aforementioned outstanding nanomaterial properties, the development of fiber optic biosensors has been efficiently promoted. This paper reviews the application of numerous novel nanomaterials in the field of optical fiber biosensing and provides a brief explanation of the fiber sensing mechanism.

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A plug-and-play optical fiber SPR sensor for simultaneous measurement of glucose and cholesterol concentrations

Cited by 70 publications

References 28 publications

Highly sensitive and stable probe refractometer based on configurable plasmonic resonance with nano-modified fiber core

Highly sensitive and stable probe refractometer based on configurable plasmonic resonance with nano-modified fiber core

Ultrasensitive Optical Fiber Sensors Working at Dispersion Turning Point: Review

Advances in Novel Nanomaterial-Based Optical Fiber Biosensors—A Review

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