A plug, print &amp; play inkjet printing and impedance-based biosensing technology operating through a smartphone for clinical diagnostics

Rosati, Giulio; Urban, Massimo; Zhao, Lei; Yang, Qiuyue; Silva, Cecilia de Carvalho Castro; Bonaldo, Stefano; Parolo, Claudio; Nguyen, Emily P.; Ortega, Gabriel; Fornasiero, Paolo; Paccagnella, A.; Merkoçi, Arben

doi:10.1016/j.bios.2021.113737

Cited by 41 publications

(23 citation statements)

References 24 publications

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“…Talukder et al reported a smartphone-based microfluidic impedance cytometer for personalized monitoring of blood cell count [ 69 ]. Another impedimetric printed electrochemical sensor was combined with a smartphone interface by Rosati et al for rapid detection of neutrophil gelatinase-associated lipocalin in urine [ 70 ]. The overall response obtained from the electrochemical sensor was transferred via Bluetooth to a mobile application.…”

Section: Smartphone-based Sensing Methodsmentioning

confidence: 99%

“…The overall response obtained from the electrochemical sensor was transferred via Bluetooth to a mobile application. Electrochemical sensing systems are promising for smartphone integration as they have high simplicity of fabrication [ 70 , 71 , 72 ]. Thus, it is expected that multiplexing smartphone-based electrochemical systems can accelerate accurate diagnostics, allowing the detection of various biomarkers simultaneously by using amperometric, voltametric, or impedimetric detection techniques.…”

Section: Smartphone-based Sensing Methodsmentioning

confidence: 99%

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Smartphone-Based Multiplexed Biosensing Tools for Health Monitoring

et al. 2022

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Many emerging technologies have the potential to improve health care by providing more personalized approaches or early diagnostic methods. In this review, we cover smartphone-based multiplexed sensors as affordable and portable sensing platforms for point-of-care devices. Multiplexing has been gaining attention recently for clinical diagnosis considering certain diseases require analysis of complex biological networks instead of single-marker analysis. Smartphones offer tremendous possibilities for on-site detection analysis due to their portability, high accessibility, fast sample processing, and robust imaging capabilities. Straightforward digital analysis and convenient user interfaces support networked health care systems and individualized health monitoring. Detailed biomarker profiling provides fast and accurate analysis for disease diagnosis for limited sample volume collection. Here, multiplexed smartphone-based assays with optical and electrochemical components are covered. Possible wireless or wired communication actuators and portable and wearable sensing integration for various sensing applications are discussed. The crucial features and the weaknesses of these devices are critically evaluated.

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Section: Smartphone-based Sensing Methodsmentioning

confidence: 99%

Section: Smartphone-based Sensing Methodsmentioning

confidence: 99%

Smartphone-Based Multiplexed Biosensing Tools for Health Monitoring

et al. 2022

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“…Through binding with the target, the impedance of device will change, resulting in signal changes that are correlated with NGAL concentrations. They combined this design with their proposal of ‘Plug, Print & Play technology’, which referred to handy equipment and easy impedance measurement via the audio input of a smartphone, realizing low-cost, simplicity and the concept of point-of-care [ 23 ]. The LOD of this device was 3 nmol/L in artificial urine.…”

Section: Diagnostics Of Aki Based On Nucleic Acid Nanotechnologymentioning

confidence: 99%

Nucleic Acid Nanotechnology for Diagnostics and Therapeutics in Acute Kidney Injury

Ying

Tang

Han

et al. 2022

IJMS

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Acute kidney injury (AKI) has impacted a heavy burden on global healthcare system with a high morbidity and mortality in both hospitalized and critically ill patients. However, there are still some shortcomings in clinical approaches for the disease to date, appealing for an earlier recognition and specific intervention to improve long-term outcomes. In the past decades, owing to the predictable base-pairing rule and highly modifiable characteristics, nucleic acids have already become significant biomaterials for nanostructure and nanodevice fabrication, which is known as nucleic acid nanotechnology. In particular, its excellent programmability and biocompatibility have further promoted its intersection with medical challenges. Lately, there have been an influx of research connecting nucleic acid nanotechnology with the clinical needs for renal diseases, especially AKI. In this review, we begin with the diagnostics of AKI based on nucleic acid nanotechnology with a highlight on aptamer- and probe-functionalized detection. Then, recently developed nanoscale nucleic acid therapeutics towards AKI will be fully elucidated. Furthermore, the strengths and limitations will be summarized, envisioning a wiser and wider application of nucleic acid nanotechnology in the future of AKI.

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“…Inkjet printing (IJP) is an important technology for individualised healthcare [1], with applications ranging from biosensor production [2][3][4] to cell printing [5,6]. IJP is the deposition of small volumes of liquid from a cartridge.…”

Section: Introductionmentioning

confidence: 99%

Printing Drugs onto Nails for Effective Treatment of Onychomycosis

et al. 2022

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Inkjet printing (IJP) is an emerging technology for the precision dosing of medicines. We report, for the first time, the printing of the antifungal drug terbinafine hydrochloride directly onto nails for the treatment of onychomycosis. A commercial cosmetic nail printer was modified by removing the ink from the cartridge and replacing it with an in-house prepared drug-loaded ink. The drug-loaded ink was designed so that it was comparable to the commercial ink for key printability properties. Linear drug dosing was shown by changing the lightness of the colour selected for printing (R2 = 0.977) and by printing multiple times (R2 = 0.989). The drug loads were measured for heart (271 µg), world (205 µg) and football (133 µg) shapes. A disc diffusion assay against Trpytophan rubrum showed inhibition of fungal growth with printed-on discs. In vitro testing with human nails showed substantial inhibition with printed-on nails. Hence, this is the first study to demonstrate the ability of a nail printer for drug delivery, thereby confirming its potential for onychomycosis treatment.

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A plug, print & play inkjet printing and impedance-based biosensing technology operating through a smartphone for clinical diagnostics

Cited by 41 publications

References 24 publications

Smartphone-Based Multiplexed Biosensing Tools for Health Monitoring

Smartphone-Based Multiplexed Biosensing Tools for Health Monitoring

Nucleic Acid Nanotechnology for Diagnostics and Therapeutics in Acute Kidney Injury

Printing Drugs onto Nails for Effective Treatment of Onychomycosis

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