This paper presents the Large Eddy Simulation of a Low-Pressure Turbine Nozzle Guide Vane for different Reynolds (Re) and Mach numbers (Ma) with or without inlet turbulence prescribed. The analysis is based on a slice of a LPT blading representative of a midspan flow. The characteristic Re of the LPT can vary by a factor of four between take-off and cruise conditions. In addition, the LPT operates at different Ma and the incident flow can have significant levels of turbulence due to upstream blade wakes. The paper investigates numerically using LES the flow around a LPT blading with three different Reynolds number Re = 175'000 (cruise), 280'000 (mid-level altitude) and 500'000 (take-off) keeping the same characteristic Mach number Ma = 0.2 and three different Mach number Ma = 0.2, 0.5 and 0.8 keeping the same Reynolds number Re= 280'000. These different simulations are performed with 0% Free Stream Turbulence (FST) followed by inlet turbulence (6% FST). The study focuses on different flow characteristics: pressure distribution around the blade, near-wall flow behavior, loss generation and Turbulent Kinetic Energy budget. The results show an earlier boundary layer separation on the aft of the blade suction side when the Re is increased while the free-stream turbulence delays separation. The TKE budget shows the predominant effect of the turbulent production and diffusion in the wake, the axial evolution of these different terms being relatively insensitive to Re and Ma.