A polyethyleneimine-driven self-assembled nanoplatform for fluorescence and MR dual-mode imaging guided cancer chemotherapy

Sun, Xiao; Zhang, Mingzhu; Du, Rongguang; Zheng, Xiaojia; Tang, Caiguo; Wu, Yiqun; He, Jiacai; Huang, Wei; Wang, Yuanyin; Zhang, Zhiyuan; Han, Xiao-Lan; Qian, Junchao; Zhong, Kai; Tian, Xiaohe; Wu, Lifang; Zhang, Guilong; Wu, Zhengyan; Zou, Duohong

doi:10.1016/j.cej.2018.05.157

Cited by 26 publications

(11 citation statements)

References 44 publications

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“…In a very recent work 189, Sun et al designed and fabricated a nano-platform for T 1 -weighted MR/fluorescence dual-modal imaging and imaging-guided cancer chemotherapy. They first synthesized a PEI-driven self-assembled Gd-/Eu-doped CaF 2 nanocluster (GECN) as the core, loaded the anti-cancer drug cisplatin (CDDP), and then coated the core by PEG-coupled FA.…”

Section: Copolymer-based Nanoparticles For Mr Cancer Theranosticsmentioning

confidence: 99%

Dendrimer- and copolymer-based nanoparticles for magnetic resonance cancer theranostics

Ray¹,

Zhao²,

Hsu³

et al. 2018

Theranostics

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Cancer theranostics is one of the most important approaches for detecting and treating patients at an early stage. To develop such a technique, accurate detection, specific targeting, and controlled delivery are the key components. Various kinds of nanoparticles have been proposed and demonstrated as potential nanovehicles for cancer theranostics. Among them, polymer-like dendrimers and copolymer-based core-shell nanoparticles could potentially be the best possible choices. At present, magnetic resonance imaging (MRI) is widely used for clinical purposes and is generally considered the most convenient and noninvasive imaging modality. Superparamagnetic iron oxide (SPIO) and gadolinium (Gd)-based dendrimers are the major nanostructures that are currently being investigated as nanovehicles for cancer theranostics using MRI. These structures are capable of specific targeting of tumors as well as controlled drug or gene delivery to tumor sites using pH, temperature, or alternating magnetic field (AMF)-controlled mechanisms. Recently, Gd-based pseudo-porous polymer-dendrimer supramolecular nanoparticles have shown 4-fold higher T1 relaxivity along with highly efficient AMF-guided drug release properties. Core-shell copolymer-based nanovehicles are an equally attractive alternative for designing contrast agents and for delivering anti-cancer drugs. Various copolymer materials could be used as core and shell components to provide biostability, modifiable surface properties, and even adjustable imaging contrast enhancement. Recent advances and challenges in MRI cancer theranostics using dendrimer- and copolymer-based nanovehicles have been summarized in this review article, along with new unpublished research results from our laboratories.

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Section: Copolymer-based Nanoparticles For Mr Cancer Theranosticsmentioning

confidence: 99%

Dendrimer- and copolymer-based nanoparticles for magnetic resonance cancer theranostics

Ray¹,

Zhao²,

Hsu³

et al. 2018

Theranostics

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“…[ 199 ] Ca 2+ is also the main component of bone and tooth, and thus expected to have good biocompatibility. [ 200 ] Due to the large available surface area, good biocompatibility and biodegradability, nano calcium silicate of various shapes, such as nanowires, [ 201 ] and nanospheres, [ 202 ] have received increasing attention in biomedical applications, including drug delivery. [ 203 ] In particular, the pH‐responsive calcium silicate drug delivery system is a promising design that may enhance the therapeutic outcomes from chemotherapy.…”

Section: Tuning Siliceous Framework By Embedding Inorganic Speciesmentioning

confidence: 99%

Tuning Nanosiliceous Framework for Enhanced Cancer Theranostic Applications

et al. 2021

Advanced Therapeutics

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As nanotechnology rapidly advances, siliceous nanomaterials have become increasingly examined for biomedical applications. To further expand their advantageous physicochemical properties and counter intrinsic limitations challenging their progress toward clinical translation, strategies ranging from new fabrication methods to diverse forms of modifications have been proposed. Among them, direct incorporation of foreign species into the siliceous frameworks has emerged. The incorporation of inorganic or organic moieties into an otherwise purely siliceous framework enriches the structure with novel or improved properties. In this review, the progress of inorganic modification is mainly examined on mesoporous silica nanoparticles (MSNs) due to their widely appreciated attributes that garnered them an important position within cancer nanomedicine, while organic modifications are studied through designs of mesoporous organosilica nanoparticles (MONs). General synthesis methods and philosophies behind framework modifications are first discussed in brief. Subsequently, several interesting inorganically doped MSNs and formulations of MONs are studied for their advantages, including the role of catalysis after metal impregnation, improved biodegradability, novel stimuli‐responsiveness, role in bioimaging, and enhancing the outcomes of key treatment strategies. Finally, the advances are summarized, along with proposed prospects for these hybrid materials in their progress toward clinical use.

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“…Nanomaterials have been developed for a variety of nanomedical applications, particularly in cancer therapy. [153,154] Current research reveal that malignant tumors soon undergo pathological angiogenesis and develop new blood vessels that are often characterized by abnormalities including inconsistent diameters and increased permeability, to meet its growing needs. The formation of gaps within the new vasculature, which can be up to 2 µm, are reported to facilitate the transport of both nutrient and nanoparticles into the tumoral region.…”

Section: Redesigning the Physicochemical Parameters Of Ahcns To Overcmentioning

confidence: 99%

Retooling Cancer Nanotherapeutics’ Entry into Tumors to Alleviate Tumoral Hypoxia

Sun

et al. 2020

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The contribution of the TME in the progress of the malignant tumor is significant and now also increasingly recognized to affect the efficiencies of drug delivery and distribution within tumors. [8] Hypoxia is the phenomenon where the oxygen supplied through the usually aberrant tumor blood vessels are insufficient to consistently meet the growing tumor's metabolic needs. [9] Hypoxia occurs in tumors due to insufficient oxygen supply in relation to the tumors' metabolism and includes: a) acute hypoxia, the result of poor blood perfusion caused by abnormal, aberrant vasculature, giving rise to tortuous network organization, irregular flow pattern, [4] and b) chronic hypoxia, the cause and the result of a sparse vascular density in the tumor, giving rise to insufficient oxygen delivered to tumor cells spatially distant from blood vessels. Compensatory angiogenesis itself is also regarded as the result of mainly nutrient and oxygen deprivation as the tumor grows. [10] Hence, hypoxia is an element in the TME that is closely interconnected with pathological angiogenesis and extracellular matrix in cancer. In general, cells are sensitive to low oxygen conditions, which activate the hypoxia-inducible factor (HIF) family of transcriptional factors to allow for expression of genes that may enhance tumor survival under the hypoxic environment. One consequential outcome is the accumulation of vascular endothelial growth factor (VEGF) under transcription by HIF-1α, resulting in the induction of angiogenesis. [11] Under hypoxia, the oxygen-dependent subunit of HIF-1, HIF-1α, is successfully accumulated (otherwise degraded in normoxic conditions) to dimerize with an oxygen-independent subunit to form the HIF-1 dimer. [4] HIF-1 then upregulates dozens of genes that allows for both adaptation and long-term expansion of the tumor cells. [12] Hypoxia is a critical factor to examine, as there is increasing recognition of its role as a potential target during cancer therapy, although the dual role of HIFs in both promoting survival and apoptosis poses a challenge for certain tumor types and cases. [13] 1.2. Hypoxia Aggravates the Challenges for Cancer Therapy A major consequence of hypoxia is the occurrence of hypoxiainduced metastasis. Hypoxia and metastasis have been Anti-hypoxia cancer nanomedicine (AHCN) holds exciting potential in improving oxygen-dependent therapeutic efficiencies of malignant tumors. However, most studies regarding AHCN focus on optimizing structure and function of nanomaterials with presupposed successful entry into tumor cells. From such a traditional perspective, the main barrier that AHCN needs to overcome is mainly the tumor cell membrane. However, such an oversimplified perspective would neglect that real tumors have many biological, physiological, physical, and chemical defenses preventing the current state-of-the-art AHCNs from even reaching the targeted tumor cells. Fortunately, in recent years, some studies are beginning to intentionally focus on overcoming physiological barriers to alleviate hypoxi...

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A polyethyleneimine-driven self-assembled nanoplatform for fluorescence and MR dual-mode imaging guided cancer chemotherapy

Cited by 26 publications

References 44 publications

Dendrimer- and copolymer-based nanoparticles for magnetic resonance cancer theranostics

Dendrimer- and copolymer-based nanoparticles for magnetic resonance cancer theranostics

Tuning Nanosiliceous Framework for Enhanced Cancer Theranostic Applications

Retooling Cancer Nanotherapeutics’ Entry into Tumors to Alleviate Tumoral Hypoxia

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