A polygenic stacking classifier revealed the complicated platelet transcriptomic landscape of adult immune thrombocytopenia

Xu, Chen; Zhang, Ruochi; Duan, Meiyu; Zhou, Yongming; Jizhang, Bao; Lu, Hao; Wang, Jie; Hu, Minghui; Hu, Zhaoyang; Zhou, Fengfeng; Zhu, Wenwei

doi:10.1016/j.omtn.2022.04.004

Cited by 6 publications

(2 citation statements)

References 84 publications

(82 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Since pseudogenes show high structural conservation, they may also participate in or regulate 14-3-3ζ's antigenic function. Use of YWHAZP5 as a biomarker of autoimmune thrombocytopenia, increased expression of YWHAZP2, YWHAZP3, and YWHAZP10 in the LPS-stimulated PBMC of systemic juvenile idiopathic arthritis patients, presence of YWHAZP3, YWHAZP4, and YWHAZP10 in synovial tissue macrophages from rheumatoid arthritis patients in disease remission, may suggest their involvement in maintaining immune status [55]. Like YWHAZ, some pseudogenes (YWHAZP4 and YWHAZP6) exhibit tissue-specific expression in the reproductive organs.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Structural Features and Physiological Associations of Human 14-3-3ζ Pseudogenes

Lughmani,

Patel,

Chakravarti

2024

Genes

View full text Add to dashboard Cite

There are about 14,000 pseudogenes that are mutated or truncated sequences resembling functional parent genes. About two-thirds of pseudogenes are processed, while others are duplicated. Although initially thought dead, emerging studies indicate they have functional and regulatory roles. We study 14-3-3ζ, an adaptor protein that regulates cytokine signaling and inflammatory diseases, including rheumatoid arthritis, cancer, and neurological disorders. To understand how 14-3-3ζ (gene symbol YWHAZ) performs diverse functions, we examined the human genome and identified nine YWHAZ pseudogenes spread across many chromosomes. Unlike the 32 kb exon-to-exon sequence in YWHAZ, all pseudogenes are much shorter and lack introns. Out of six, four YWHAZ exons are highly conserved, but the untranslated region (UTR) shows significant diversity. The putative amino acid sequence of pseudogenes is 78–97% homologous, resulting in striking structural similarities with the parent protein. The OMIM and Decipher database searches revealed chromosomal loci containing pseudogenes are associated with human diseases that overlap with the parent gene. To the best of our knowledge, this is the first report on pseudogenes of the 14-3-3 family protein and their implications for human health. This bioinformatics-based study introduces a new insight into the complexity of 14-3-3ζ’s functions in biology.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Second, we manually mined the transcriptomics-based studies for pseudogenes in human diseases. A recent study shows that YWHAZP5 is one of the 40 biomarkers of adult immune thrombocytopenia in humans [55]. The locus associated with YWHAZP7 is expressed in glioblastomas [56].…”

Section: Physiological Aspect Of Pseudogenesmentioning

confidence: 99%