A Polymer Optoelectronic Interface Provides Visual Cues to a Blind Retina

Gautam, Vini; Rand, David G.; Hanein, Yael; Narayan, K. S.

doi:10.1002/adma.201304368

Cited by 115 publications

(110 citation statements)

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“…Therefore, for rational design of the conductor with high stretchability and stability, the maximum stress of the reported wrinkled metal fi lm [ 61 ] (take gold as an example; Figure 1 a Monitoring neural activity by external devices has attracted much attention for gaining a deeper understanding of electrophysiological signals, [1][2][3][4][5][6][7] enhancing the response of therapies, [8][9][10][11][12][13][14][15] and promoting the establishment of human-machine interfaces. [16][17][18][19][20][21] Neural electrodes have evolved from solid materials with predefi ned shape and dimension to highly synthetic materials with engineered texture and tailored chemical properties. [ 1,[22][23][24][25][26][27][28] Proper operation of such devices requires that the materials show good conductivity, longevity, and are biocompatibility.…”

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confidence: 99%

Highly Stretchable Gold Nanobelts with Sinusoidal Structures for Recording Electrocorticograms

et al. 2015

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confidence: 99%

Highly Stretchable Gold Nanobelts with Sinusoidal Structures for Recording Electrocorticograms

et al. 2015

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“…In our recently reported work, 14 we interfaced these optoelectronic polymer structures with a developing chick retina at a light-insensitive stage and showed their utility to elicit neuronal signals in the blind retina (Fig. 1B).…”

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confidence: 97%

“…14 The temporal properties of the evoked retinal response correlated with the optoelectronic response of the polymer film. For instance, the response latency, the total number of spikes and the spike rate depended on light intensity, time duration and time interval of the incident light pulse used for photoexcitation of the BHJ layer.…”

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confidence: 99%

“…12 The polymer layer utilized in our studies consisted of a binary Keywords: optoelectronics, polymer interface, bulk heterojunction, retina, implants blend-mixture, which is technically referred as bulkheterojunction (BHJ), with regio-regular poly-alkylthiophenes (rrP3AT) as the donor (p) component and a naphthalene derivative (N2200) as the acceptor (n) component. [12][13][14] The BHJ aspect of the active layer is responsible for a wider absorption range and significant photoinduced carrier generation (higher quantum efficiency) compared with that in a pristine single component layer.…”

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Polymer optoelectronic structures for retinal prosthesis

Gautam

Narayan

2014

Organogenesis

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This commentary highlights the effectiveness of optoelectronic properties of polymer semiconductors based on recent results emerging from our laboratory, where these materials are explored as artificial receptors for interfacing with the visual systems. Organic semiconductors based polymer layers in contact with physiological media exhibit interesting photophysical features, which mimic certain natural photoreceptors, including those in the retina. The availability of such optoelectronic materials opens up a gateway to utilize these structures as neuronal interfaces for stimulating retinal ganglion cells. In a recently reported work entitled "A polymer optoelectronic interface provides visual cues to a blind retina," we utilized a specific configuration of a polymer semiconductor device structure to elicit neuronal activity in a blind retina upon photoexcitation. The elicited neuronal signals were found to have several features that followed the optoelectronic response of the polymer film. More importantly, the polymer-induced retinal response resembled the natural response of the retina to photoexcitation. These observations open up a promising material alternative for artificial retina applications.

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“…CPs produce negligible heat and are flexible [123,124]. Additionally, organic retinal prosthesis based on CPs have been demonstrated [125][126][127], although their in vivo biocompatibility and functional lifetime have yet to be established. Besides the retina, biocompatible photodetectors may be implanted in the body for optical sensing and imaging.…”

Section: Photodetectorsmentioning

confidence: 99%

Toward biomaterial-based implantable photonic devices

et al. 2017

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Optical technologies are essential for the rapid and efficient delivery of health care to patients. Efforts have begun to implement these technologies in miniature devices that are implantable in patients for continuous or chronic uses. In this review, we discuss guidelines for biomaterials suitable for use in vivo. Basic optical functions such as focusing, reflection, and diffraction have been realized with biopolymers. Biocompatible optical fibers can deliver sensing or therapeutic-inducing light into tissues and enable optical communications with implanted photonic devices. Wirelessly powered, light-emitting diodes (LEDs) and miniature lasers made of biocompatible materials may offer new approaches in optical sensing and therapy. Advances in biotechnologies, such as optogenetics, enable more sophisticated photonic devices with a high level of integration with neurological or physiological circuits. With further innovations and translational development, implantable photonic devices offer a pathway to improve health monitoring, diagnostics, and light-activated therapies.

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A Polymer Optoelectronic Interface Provides Visual Cues to a Blind Retina

Cited by 115 publications

References 34 publications

Highly Stretchable Gold Nanobelts with Sinusoidal Structures for Recording Electrocorticograms

Highly Stretchable Gold Nanobelts with Sinusoidal Structures for Recording Electrocorticograms

Polymer optoelectronic structures for retinal prosthesis

Toward biomaterial-based implantable photonic devices

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