A polymorphic marker Val109Asp in the omentin gene are associated with abdominal obesity in the Kyrgyz population

Abstract

Aim — in this study, we investigated whether polymorphisms Val109Asp in the omentin gene are associated with abdominal obesity in the Kyrgyz population.Material and methods. We genotyped 297 nonrelated adults Kyrgyz individuals. 127 patients (male — 46, female — 81, average age — 53±7,0) with abdominal obesity (elevated waist circumferences ≥102 cm for male subjects and ≥ 88 cm for female) and 170 non-obese control subjects (male — 107, female — 63, average age 51±9). Val109Asp polymorphisms analysis in the omentin gene were performed by PCR-RFLP method.Results. There were significant differences in genotype distributions of rs2274907 between the obese and control cohorts (p=0.01). Frequencies of Asp109Asp, Val109Asp and Val109Val genotypes among patients with abdominal obesity were 48, 40 and 12%, respectively, that differed from those among controls (Asp109Asp — 53%, Val109Aspl — 43% and Val109Val — 4%); there was significant difference in genotype frequencies between two groups (χ²=6,29; p=0,043). Homozygous genotype Val109Val was more frequent in the obese than non-obese group. The genotype Val109Val of omentin gene is associated with a high risk of developing abdominal obesity in the Kyrgyz population (OR=3,12; 95% CI 1,23—7,90). Homozygous genotype Asp109Asp, reduces the risk of developing abdominal obesity (OR=0,82; 95% CI 0,53—1,30). The allelic variants of the polymorphisms Val109Asp in the omentin gene were not found to be associated with abdominal obesity.Conclusion. There is significant association between Val109Asp polymorphism in omentin gene and abdominal obesity in the Kyrgyz Population. An increased risk of abdominal obesity associated with homozygous genotype — Val109Val in omentin gene.

Omentin rs2274907 gene polymorphism and the risk of metabolic syndrome: a preliminary report

“…This may indicate the existence of a potential, more "thrifty" phenotype in these people. In the Kyrgyz population, it was confirmed that the genotype Val109Val in omentin gene increased the risk of abdominal obesity -one of the MetS components [18]. The results of our research are to some extent consistent with the results of the papers cited above, because in the adjusted model, carriers of the Asp allele (as compared to the carriers of the Val allele) showed quite a clear, though statistically insignificant, tendency to a lower risk of abdominal obesity (OR = 0.65; p = 0.169) and MetS (OR = 0.69; p = 0.181).…”

“…In the Caucasian population, however, no relationship was found between the mutations of the omentin gene and the occurrence of type 2 diabetes [17]. In the Kyrgyz population, however, it was noted that the genotype Val109Val in the omentin gene increased the risk of abdominal obesity -one of the MetS components [18]. In the available literature, no work has been published so far on the relationship between polymorphisms of the omentin gene and MetS.…”

The roles of vaspin, chemerin, and omentin in the determination of metabolic syndrome

“…An increased risk of abdominal obesity was associated with homozygous genotype Val109Val. Frequencies of Asp109Asp, Val109Asp, and Val109Val genotypes among individuals with abdominal obesity (48,40, and 12%, respectively) were different from those among control subjects (Asp109Asp -53%, Val109Asp -43%, and Val109Val -4%) [168]. Saremi et al examined the effects of 12 weeks of aerobic training on serum omentin-1 concentrations [169].…”