A polymorphism associated with STAT3 expression and response of chronic myeloid leukemia to interferon  

STAT3 gene polymorphisms and susceptibility to non-small cell lung cancer

“…Our data provided the first evidence that polymorphisms in the STAT3 gene may have a protective role in the development of NSCLC, particular of stage III/IV NSCLC. Because STAT3 polymorphisms have been correlated with therapy response in certain malignancies (Ito et al, 2007;Kreil et al, 2010), the STAT3 polymorphisms identified to be associated with decreased NSCLC risk in the present study could be helpful to predict how these patients would respond to therapy targeting STAT3 pathways. Future studies are needed to validate our findings and to investigate the potential effects of these SNPs on STAT3 expression and function.…”

“…It has been reported that overexpression of STAT3 is correlated with growth, survival, and radioresistance of NSCLC cells, and that STAT3 inhibition could inhibit tumorigenic ability and enhance the radiosensitivity of NSCLC cells both in vitro and in vivo (Yin et al, 2010;Hsu et al, 2011). Moreover, STAT3 polymorphisms have been shown to correlate with STAT3 expression and therapy response in certain malignancies (Ito et al, 2007;Kreil et al, 2010). Therefore, identification of STAT3 polymorphisms that are associated with NSCLC risk (either increased or decreased) is important, because it could help predict therapy response, particularly to EGFR inhibitors as STAT3 has been shown to be required to mediate the oncogenic effects of EGFR in NSCLC (Lai and Johnson, 2010).…”

WITHDRAWN: Interleukin-21 receptor gene polymorphism is associated with hepatitis B virus-related hepatocellular carcinoma in Chinese patients

“…IL-21 polymorphisms are associated with systemic lupus erythematosus [20], Graves' disease [21], ischemic stroke [22], chronic hepatitis B infection [23], breast cancer [24] and thyroid cancer [25]. Moreover, polymorphisms in the IL21-JAK-STAT signaling pathway are associated with cardiovascular disease [26], breast cancer [27], renal cell carcinoma [28] and chronic myelogenous leukemia [29]. IL-21 gene polymorphisms such as rs12508721 T/C and rs2221903 A/G are also recognized as risk factors for HBV-related HCC and chronic HBV infections [30].…”

Association between the <b><i>IFNA1 </i></b>(-2C&#x2192;T) Polymorphism and Increased <b><i>IFNAR1 </i></b>Gene Expression Levels in Chronic Hepatitis B Infection

“…Nevertheless, when the same region was analyzed regarding progression and susceptibility to HIV-I in a French cohort study [19] and the IFN-α response in chronic myeloid leukemia cases [20], no significant differences were identified. The present study, though, confirms the allelic distribution identified by Diop et al [20] in 2006 in both case and control groups.…”

“…Controversy exists whether or not these genes are significantly associated with chronic HBV infection and other diseases [19,20], or their location near promoter genes. Thus, polymorphisms in these promoter region genes might influence the gene expression pattern associated with the clinical outcome of persistent HBV infection [16].…”