A polymorphism in the haptoglobin, haptoglobin related protein locus is associated with risk of human sleeping sickness within Cameroonian populations

Ofon, Elvis; Noyes, Harry; Mulindwa, Julius; Ilboudo, Hamidou; Simuunza, Martin; Ebo’o, Vincent; Njiokou, Flobert; Koffi, Mathurin; Bucheton, Bruno; Fogue, Pythagore Soubgwi; Hertz‐Fowler, Christiane; MacLeod, Annette; Simo, Gustave

doi:10.1371/journal.pntd.0005979

Cited by 15 publications

(22 citation statements)

References 57 publications

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“…Since the launch of the TrypanoGen network, studies highlighting or confirming the association between different SNPs in a number of genes (HP, IL6, APOL1) and the individual variability in susceptibility to the development of HAT have been published. These results further prove the importance of the genetic component in the susceptibility to sleeping sickness in the human host …”

Section: Genomics To Study Susceptibility To Hatsupporting

confidence: 59%

“…In the Democratic Republic of the Congo, it was also observed an association between decreased risk of HAT and polymorphisms in IL‐6 and IL‐10 genes . More recently, an association with single‐nucleotide polymorphisms (SNPs) in the haptoglobin gene and a reduced risk of HAT was reported in a gene association study in Cameroon …”

Section: Genomics To Study Susceptibility To Hatmentioning

confidence: 94%

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Sleeping Sickness in the ‘Omics Era

Tiberti

Sanchez

2018

Proteomics Clinical Apps

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Sleeping sickness is a neglected tropical disease caused by Trypanosoma brucei parasites, affecting the poorest communities in sub-Saharan Africa. The great efforts done by the scientific community, local governments, and non-governmental organizations (NGOs) via active patients' screening, vector control, and introduction of improved treatment regimens have significantly contributed to the reduction of human African trypanosomiasis (HAT) incidence during the last 15 years. Consequently, the WHO has announced the objective of HAT elimination as a public health problem by 2020. Studies at both parasite and host levels have improved our understanding of the parasite biology and the mechanisms of parasite interaction with its mammalian host. In this review, the impact that 'omics studies have had on sleeping sickness by revealing novel properties of parasite's subcellular organelles are summarized, by highlighting changes induced in the host during the infection and by proposing potential disease markers and therapeutic targets.

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Section: Genomics To Study Susceptibility To Hatsupporting

confidence: 59%

Section: Genomics To Study Susceptibility To Hatmentioning

confidence: 94%

Sleeping Sickness in the ‘Omics Era

Tiberti

Sanchez

2018

Proteomics Clinical Apps

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“…So far, results concerning four countries have been published. [84][85][86][87] Associations were found between HLA-G SNPs and the disease incidence and severity in Cameroon, Ivory Coast and Uganda. In a population of 55 HAT cases and 100 controls in Cameroon, the G allele of SNP rs1233330 was associated with a decreased risk of disease, while the A allele of SNP rs17875389 increased the risk of developing HAT.…”

Section: Human African Trypanosomiasismentioning

confidence: 97%

“…In a population of 55 HAT cases and 100 controls in Cameroon, the G allele of SNP rs1233330 was associated with a decreased risk of disease, while the A allele of SNP rs17875389 increased the risk of developing HAT. 87 In Ivory Coast, the T allele of SNP rs1611139 was associated with an increased risk to have latent infection in a population of 32 SERO and 100 controls. 84 The population under study in Uganda was subdivided into two groups: the first one (n = 239) containing 120 Tbr HAT cases and 119 controls and the second one (n = 223) composed of 110 Tbg HAT cases and 113 controls.…”

Section: Human African Trypanosomiasismentioning

confidence: 98%

“…The role played by HLA-G in the variable clinical outcomes of HAT was investigated in six different studies. [82][83][84][85][86][87] The only study directly addressing HLA-G expression was conducted in mangrove areas of coastal Guinea. 83 Individuals included in the follow-up were classified into three groups according to the results of serological and parasitological tests: (1) Seropositive group (SERO) composed of individuals serologically positive to CATT and trypanolysis tests and negative in parasitological tests during the twoyear follow-up, (2) Latent infection group (SERO/HAT) comprising seropositive individuals who became positive in parasitological tests during their follow-up and (3) HAT group composed of patients positive in both serological and parasitological tests.…”

Section: Human African Trypanosomiasismentioning

confidence: 99%

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The role of HLA‐G in parasitic diseases

Sabbagh

Sonon

Sadissou

et al. 2018

HLA

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Little attention has been devoted to the role of HLA-G gene and molecule on parasitic disorders, and the available studies have focused on malaria, African and American trypanosomiasis, leishmaniosis, toxoplasmosis and echinococcosis. After reporting a brief description regarding the role of the cells of innate and adaptive immune system against parasites, we reviewed the major features of the HLA-G gene and molecule and the role of HLA-G on the major cells of immune system. Increased levels of soluble HLA-G (sHLA-G) have been observed in patients presenting toxoplasmosis and in the active phase of echinococcosis. In addition, increased sHLA-G has also been associated with increased susceptibility to malaria and increased susceptibility to develop human African trypanosomiasis (HAT). In contrast, decreased membrane-bound HLA-G has been reported in placenta of patients infected with Plasmodium falciparum and in heart and colon of patients presenting Chagas disease. The 3' untranslated region of the HLA-G gene has been the main focus of studies on malaria, HAT and Chagas disease, exhibiting distinct patterns of associations. Considering that HLA-G is an immune checkpoint molecule, inhibiting the activity of several cells of the immune system, the excessive neoexpression and the increased sHLA-G levels together with the decreased constitutive tissue expression of membrane-bound HLA-G may be detrimental to the host infected with parasite agents.

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Implications of asymptomatic infection for the natural history of selected parasitic tropical diseases

et al. 2020

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Progress has been made in the control or elimination of tropical diseases, with a significant reduction of incidence. However, there is a risk of re-emergence if the factors fueling transmission are not dealt with. Although it is essential to understand these underlying factors for each disease, asymptomatic carriers are a common element that may promote resurgence; their impact in terms of proportion in the population and role in transmission needs to be determined. In this paper, we review the current evidence on whether or not to treat asymptomatic carriers given the relevance of their role in the transmission of a specific disease, the efficacy and toxicity of existing drugs, the Public Health interest, and the benefit at an individual level, for example, in Chagas disease, to prevent irreversible organ damage. In the absence of other control tools such as vaccines, there is a need for safer drugs with good risk/benefit profiles in order to change the paradigm so that it addresses the complete infectious process beyond manifest disease to include treatment of non-symptomatic infected persons.

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A polymorphism in the haptoglobin, haptoglobin related protein locus is associated with risk of human sleeping sickness within Cameroonian populations

Cited by 15 publications

References 57 publications

Sleeping Sickness in the ‘Omics Era

Sleeping Sickness in the ‘Omics Era

The role of HLA‐G in parasitic diseases

Implications of asymptomatic infection for the natural history of selected parasitic tropical diseases

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