A polymorphism in the IGF-I gene influences the age-related decline in circulating total IGF-I levels

Rietveld, Ingrid; Janssen, Joseph A M J L; Hofman, Albert; Pols, H A P; Duijn, Cornelia M. van; Lamberts, S. W. J.

doi:10.1530/eje.0.1480171

Cited by 87 publications

(80 citation statements)

References 23 publications

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“…Although IGF-I has no direct effects on adipocytes because of the lack of functional receptors in adipose tissue, it is known to enhance lipolysis by reducing insulin levels and thus releasing the brakes on lipolysis which, on theoretical grounds, could lead to less fat accumulation in wild-type carriers of this IGF-I polymorphism (36 -40). Earlier studies on the same IGF-I polymorphism in elderly subjects did not show any differences in BMI and WHR between both genotypes (2,41,42). These studies differed from our study in the slightly different way in that wild-type carrying and non-carrying of the IGF-I polymorphism were defined, as well as the age of the study groups.…”

Section: Discussioncontrasting

confidence: 95%

Association between an IGF-I gene polymorphism and body fatness: differences between generations

Voorhoeve

Rossum²,

Velde³

et al. 2006

eur j endocrinol

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Objective: A polymorphism near the promoter region of the IGF-I gene has been associated with serum IGF-I levels, body height and birth weight. In this study, we investigated whether this polymorphism is associated with body composition in young healthy subjects in two cohorts of different generations. Design: Observational study with repeated measurements. Methods: The study group consisted of two comparable young Dutch cohorts with a generational difference of around 20 years. The older cohort consisted of 359 subjects born between 1961 and 1965. Measurements were performed from 13 until 36 years of age. The younger cohort consisted of 258 subjects born between 1981 and 1989. Measurements were performed from 8 until 14 years of age. Height, body mass index (BMI), fat mass, fat-free mass, waist and hip circumference were compared between wild-type carriers and variant type carriers of the IGF-I polymorphism. Results: In the younger cohort, body weight, BMI, fat mass and waist circumference were significantly higher in female variant carriers of the IGF-I polymorphism. A similar trend was observed in male variant carriers. In contrast, these differences were not observed in the older cohort. Irrespective of genotype, the younger cohort showed a significantly higher total fat mass, body weight and BMI compared with the older cohort. Conclusions: Because the differences between both genotypes were small, it seems likely that the genetic variability due to this IGF-I polymorphism impacts only slightly on body composition. Importantly, our study suggested that associations between this IGF-I promoter polymorphism and body composition possibly reflect a gene-environmental interaction of this polymorphism and that an environment that promotes obesity leads to a slightly more pronounced fat accumulation in variant carriers of this IGF-I polymorphism.

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Section: Discussioncontrasting

confidence: 95%

Association between an IGF-I gene polymorphism and body fatness: differences between generations

Voorhoeve

Rossum²,

Velde³

et al. 2006

eur j endocrinol

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“…Another important point that should be considered is the timing of blood sampling and IGF-I evaluation on day 60 after parturition. There is a critical point involving the role of the hormones, somatomedins and cytokines that have different concentrations and roles according to physiological circumstances, sampling time and even age (Ge et al, 2001;Spicer et al, 2002;Rietveld et al, 2003). One crucial point might be the time of sampling, or even more physiologically complicated is the fact that dairy cattle at lactation time have their own local IGF-I molecule concentration in the mammary gland, rather than just the general circulation level (Cohick, 1998;Weber et al, 2000;Hadsell et al, 2002;Marshman and Streuli, 2002).…”

Section: Discussionmentioning

confidence: 99%

IGF-I gene polymorphism, but not its blood concentration, is associated with milk fat and protein in Holstein dairy cows

Bonakdar¹,

Rahmani²,

Edriss³

et al. 2010

Genet. Mol. Res.

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ABSTRACT. We estimated the allele and genotype frequencies of IGF-I/SnaBI gene polymorphism and the concentration of this protein in Holstein dairy cows. We also examined the association with milk yield (305-day milk yield) and milk components (fat and protein percentage, and 305-day milk protein and fat yield). Blood IGF-I levels were measured and genotyping was performed on 250 Holstein cows of four different herds. In the association studies, traits of interest were analyzed using the GLM procedure of SAS; means of the IGF-I level among genotypes were compared by the LSMeans test. The AB and AA genotypes were the most (0.583-0.661) and least (0.083-0.192) frequent in the herds, respectively; the frequency of the BB genotype ranged from 0.201 to 0.333. The frequency of the A allele ranged from 0.375 to 0.495, while the frequency of the B allele ranged from 0.504 to 0.625, being the dominant allele. The mean level of IGF-I was 107 ± 22 ng/mL for all groups, without IGF-I gene and milk components any significant correlation with the production traits. Association of IGF-I/SnaBI genotypes with percentage of fat and protein in the milk was relatively high (P < 0.1 and P < 0.05, respectively); the AB genotype was superior to AA and BB genotypes. We concluded that this marker should be considered for milk component selection in Holstein dairy cattle.

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“…IGF-I genotypes were determined as described previously (17). The most common allele contains 19 CA-repeats, which equals a length of 192-bp (28). In a previous study, we examined the role of the various lengths of the alleles of the IGF-I promoter polymorphism and observed an optimum for IGF-I levels and body height (29).…”

Section: Genotyping Of the Igf-i Promoter Polymorphismmentioning

confidence: 99%

An insulin-like growth factor-I gene polymorphism modifies the risk of microalbuminuria in subjects with an abnormal glucose tolerance

Rietveld

Hofman²,

Pols³

et al. 2006

eur j endocrinol

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Objective: Microalbuminuria (MA) is related to cardiovascular disease both in diabetic patients and non-diabetic subjects. Design: We investigated whether a polymorphism near the promoter region of the IGF-I gene was related to the development of MA. Methods: For this study, 1069 participants of the Rotterdam study were selected (440 participants with an abnormal glucose tolerance (AGT), 220 participants with type 2 diabetes and 254 subjects with pre-diabetes, and 595 subjects with a normal glucose tolerance (NGT). Results: 787 subjects were carriers of the wild type IGF-I genotype (73.6%) and 282 subjects were variant carriers (26.4%) of this IGF-I gene polymorphism. Compared to subjects with NGT the risk for microalbuminuria was higher (Odds Ratio (OR): 3.1 (95% CI: 1.2-7.7); P ¼ 0.02) in variant carriers with AGT than in carriers of the wild type of this IGF-I gene polymorphism (OR: 2.2 (95% CI: 1.2 -4.0); P ¼ 0.009). Compared with wild type carriers with AGT, the relative risk for MA was unadjusted and non-significantly increased in variant carriers with AGT (1.6; 95% CI: 0.8 -2.9). However, after adjustment for possible confounding factors (age, gender, mean blood pressure, fasting insulin, fasting glucose and smoking) this risk became significant (OR: RR 2.1; 95% CI:1.1 -4.4; P ¼ 0.04). Conclusions: In subjects with AGT, a higher risk for MA was observed in variant carriers than in carriers of the wild type genotype of this IGF-I gene polymorphism. Since MA is primarily associated with cardiovascular disease in subjects with AGT, our study suggests that variant carriers have a higher risk for cardiovascular disease than carriers of the wild type when they develop an AGT. European Journal of Endocrinology 154 715-721

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A polymorphism in the IGF-I gene influences the age-related decline in circulating total IGF-I levels

Cited by 87 publications

References 23 publications

Association between an IGF-I gene polymorphism and body fatness: differences between generations

Association between an IGF-I gene polymorphism and body fatness: differences between generations

IGF-I gene polymorphism, but not its blood concentration, is associated with milk fat and protein in Holstein dairy cows

An insulin-like growth factor-I gene polymorphism modifies the risk of microalbuminuria in subjects with an abnormal glucose tolerance

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