A polymorphism in the nuclear receptor coactivator 7 gene and breast cancer susceptibility

Süllner, Julia; Lattrich, Claus; Haring, John H.; Görse, R.; Ortmann, O.; Treeck, Oliver

doi:10.3892/ol.2011.421

Cited by 7 publications

(7 citation statements)

References 19 publications

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“…Although NCOA7 can be recruited to the promoter region of ERα target genes following estradiol treatment, NCOA7 has a lesser extent of sequence and structure homology with other coactivators, including those belonging to the SRC family, and might function as a distinct coactivator class (46). Several gene polymorphisms of NCOA7 have been associated with the development of breast cancer (64, 65). In another study, NCOA7 was identified as a potential biomarker in oral squamous cell carcinoma (53).…”

Section: Discussionmentioning

confidence: 99%

Engagement of Nuclear Coactivator 7 by 3-Hydroxyanthranilic Acid Enhances Activation of Aryl Hydrocarbon Receptor in Immunoregulatory Dendritic Cells

et al. 2019

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Indoleamine 2,3-dioxygenase 1 (IDO1) catalyzes the first step in the kynurenine pathway of tryptophan (Trp) degradation that produces several biologically active Trp metabolites. L -kynurenine (Kyn), the first byproduct by IDO1, promotes immunoregulatory effects via activation of the Aryl hydrocarbon Receptor (AhR) in dendritic cells (DCs) and T lymphocytes. We here identified the nuclear coactivator 7 (NCOA7) as a molecular target of 3-hydroxyanthranilic acid (3-HAA), a Trp metabolite produced downstream of Kyn along the kynurenine pathway. In cells overexpressing NCOA7 and AhR, the presence of 3-HAA increased the association of the two molecules and enhanced Kyn-driven, AhR-dependent gene transcription. Physiologically, conventional (cDCs) but not plasmacytoid DCs or other immune cells expressed high levels of NCOA7. In cocultures of CD4 + T cells with cDCs, the co-addition of Kyn and 3-HAA significantly increased the induction of Foxp3 + regulatory T cells and the production of immunosuppressive transforming growth factor β in an NCOA7-dependent fashion. Thus, the co-presence of NCOA7 and the Trp metabolite 3-HAA can selectively enhance the activation of ubiquitary AhR in cDCs and consequent immunoregulatory effects. Because NCOA7 is often overexpressed and/or mutated in tumor microenvironments, our current data may provide evidence for a new immune check-point mechanism based on Trp metabolism and AhR.

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Section: Discussionmentioning

confidence: 99%

Engagement of Nuclear Coactivator 7 by 3-Hydroxyanthranilic Acid Enhances Activation of Aryl Hydrocarbon Receptor in Immunoregulatory Dendritic Cells

et al. 2019

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“…Relatively little is known regarding the involvement of NCOA7 in tumorigenesis. It is shown by genome-wide association studies that several gene polymorphisms of NCOA7 were associated with the development of breast cancer [ 31 , 32 ]. Recently, individual studies demonstrated that NCOA7 regulated all-trans-retinoic acid (ATRA)-mediated neuronal differentiation and functioned as a favourable prognostic indicator for neuroblastoma [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

MALDI imaging reveals NCOA7 as a potential biomarker in oral squamous cell carcinoma arising from oral submucous fibrosis

et al. 2016

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Oral squamous cell carcinoma (OSCC) ranks among the most common cancer worldwide, and is associated with severe morbidity and high mortality. Oral submucous fibrosis (OSF), characterized by fibrosis of the mucosa of the upper digestive tract, is a pre-malignant lesion, but the molecular mechanisms underlying this malignant transformation remains to be elucidated. In this study, matrix-assisted laser desorption ionization imaging mass spectrometry (MALDI-IMS)-based proteomic strategy was employed to profile the differentially expressed peptides/proteins between OSCC tissues and the corresponding adjacent non-cancerous OSF tissues. Sixty-five unique peptide peaks and nine proteins were identified with altered expression levels. Of them, expression of NCOA7 was found to be up-regulated in OSCC tissues by immunohistochemistry staining and western blotting, and correlated with a pan of clinicopathologic parameters, including lesion site, tumor differentiation status and lymph node metastasis. Further, we show that overexpression of NCOA7 promotes OSCC cell proliferation in either in vitro or in vivo models. Mechanistic study demonstrates that NCOA7 induces OSCC cell proliferation probably by activating aryl hydrocarbon receptor (AHR). The present study suggests that NCOA7 is a potential biomarker for early diagnosis of OSF malignant transformation, and leads to a better understanding of the molecular mechanisms responsible for OSCC development.

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“…S3J). Interestingly, NCOA7 (Nuclear Receptor Coactivator 7) has been reported to have gene polymorphisms associated with breast cancer development [26,27] and it has also been identified as a potential biomarker in oral squamous cell carcinoma [28]. In addition, the engagement of NCOA7 by 3-HAA (3-hydroxyanthranilic acid) enhances the activation of AhR (aryl hydrocarbon receptor) in immunoregulatory dendritic cells [29].…”

Section: Risk Score Serves As a Risk Factor For Overall Survival In T...mentioning

confidence: 99%

Establishment and evaluation of module-based immune-associated gene signature to predict overall survival in patients of colon adenocarcinoma

et al. 2022

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Background Patients with colon adenocarcinoma (COAD) exhibit significant heterogeneity in overall survival. The current tumor-node-metastasis staging system is insufficient to provide a precise prediction for prognosis. Identification and evaluation of new risk models by using big cancer data may provide a good way to identify prognosis-related signature. Methods We integrated different datasets and applied bioinformatic and statistical methods to construct a robust immune-associated risk model for COAD prognosis. Furthermore, a nomogram was constructed based on the gene signature and clinicopathological features to improve risk stratification and quantify risk assessment for individual patients. Results The immune-associated risk model discriminated high-risk patients in our investigated and validated cohorts. Survival analyses demonstrated that our gene signature served as an independent risk factor for overall survival and the nomogram exhibited high accuracy. Functional analysis interpreted the correlation between our risk model and its role in prognosis by classifying groups with different immune activities. Remarkably, patients in the low-risk group showed higher immune activity, while those in the high-risk group displayed a lower immune activity. Conclusions Our study provides a novel tool that may contribute to the optimization of risk stratification for survival and personalized management of COAD. Graphical Abstract

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A polymorphism in the nuclear receptor coactivator 7 gene and breast cancer susceptibility

Cited by 7 publications

References 19 publications

Engagement of Nuclear Coactivator 7 by 3-Hydroxyanthranilic Acid Enhances Activation of Aryl Hydrocarbon Receptor in Immunoregulatory Dendritic Cells

Engagement of Nuclear Coactivator 7 by 3-Hydroxyanthranilic Acid Enhances Activation of Aryl Hydrocarbon Receptor in Immunoregulatory Dendritic Cells

MALDI imaging reveals NCOA7 as a potential biomarker in oral squamous cell carcinoma arising from oral submucous fibrosis

Establishment and evaluation of module-based immune-associated gene signature to predict overall survival in patients of colon adenocarcinoma

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