A polymorphism in the promoter region of the human interleukin‐16 gene is not associated with asthma or atopy in an Australian population

Akesson, Lauren S; Duffy, David L.; Phelps, S.C.; Thompson, Philip J.; Kedda, Mary-Anne

doi:10.1111/j.1365-2222.2005.02189.x

Cited by 16 publications

(8 citation statements)

References 21 publications

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“…Similar to our result in Australian population it is not associated with asthma. [ 30 ] In similar to our result, were not associated with the susceptibility and disease severity of bronchiolitis as well as IFN-gamma in Chinese population. [ 31 ] However, in Taiwan children there was strong association between IFN-gamma polymorphisms and risk of asthma.…”

Section: Discussionsupporting

confidence: 88%

Gene susceptibility in iranian asthmatic patients: A narrative review

Alizadeh‐Navaei

Rafiei

Mohammadzadeh

et al. 2014

Ann Med Health Sci Res

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As environmental factors are important in the development of asthma, genetic factors could have a critical role in the expression of the disease. Hence, we carried out a systematic review to assess the susceptible genes for asthma in Iranian population. We conducted a literature search by using the electronic database PubMed, Biological Abstracts Web of Science, Current Contents Connect, Cinahl, ScienceDirect, Scopus, IranMedex, and Scientific Information Database to identify articles that evaluated the association between genetic variants and the risk of asthma in Iranian population (until April 30, 2012). The search terms were used include: Asthma and gene in combination with Iran for international database. The following criteria were used for selecting literatures in this review: The study should evaluate the association between gene polymorphism and risk of asthma in Iranian population, and the study should be a case-control design with normal subject as ac control group that published in a journal. Finally, 14 case-control studies were extracted from local and international database. In this study, we reviewed 38 polymorphisms in 19 genes. Polymorphism in interleukin-13 (IL-13), IL-10, IL-1, IL-2, IL-12, E-Selectin, S128R and Exon 9 Vitamin D Receptor were susceptible for asthma and polymorphism in chemokine receptor 5, transforming growth factor-a (TGF-a), Intron 8 of the Vitamin D Receptor, angiotensin-converting enzyme gene, IL-6 and interferon-c were not susceptible for asthma in Iranian population. Polymorphism in IL-4, tumor necrosis factor-α and TGF-b had inconsistent findings. This systematic review indicated that three polymorphisms (IL-13, IL-10, and IL-1) are associated with risk of asthma in Iranian population.

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Section: Discussionsupporting

confidence: 88%

Gene susceptibility in iranian asthmatic patients: A narrative review

Alizadeh‐Navaei

Rafiei

Mohammadzadeh

et al. 2014

Ann Med Health Sci Res

View full text Add to dashboard Cite

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“…The recent observation that IL-16 selectively attracts and activates T H 1 cells further implies a possible discordance between diseases dependent on T H 1 versus T H 2 inflammatory processes. 28 Recently, Akesson et al 29 reported no association between the IL16 2295 promoter polymorphism and asthma in a case-control study in an Australian white population; however, case-control studies are subject to population stratification, and there was no assessment of possible population admixture in the study. Our family-based association study is not subject to confounding by population stratification.…”

Section: Discussionmentioning

confidence: 97%

Association of asthma with a functional promoter polymorphism in the IL16 gene

Burkart

Barton

Holloway

et al. 2006

Journal of Allergy and Clinical Immunology

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“…Subsequent studies confirmed that in the non-diseased state IL16 is almost exclusively expressed by T lymphocytes in lymphatic tissue, whereas in asthmatic patients IL16 is also synthesized by airway epithelial cells to inhibit airway inflammation [24]-[26]. A promoter polymorphism (T-295C) in IL16 was associated with asthma in a Caucasian population in England,[27] although this finding was not confirmed in an Australian study [28]. STARD5 belongs to the steroidogenic acute regulatory lipid transfer domain protein superfamily, and is involved in the trafficking of cholesterol and other lipids between intracellular membranes [29].…”

Section: Discussionmentioning

confidence: 98%

Large-Scale Genome-Wide Association Studies and Meta-Analyses of Longitudinal Change in Adult Lung Function

et al. 2014

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BackgroundGenome-wide association studies (GWAS) have identified numerous loci influencing cross-sectional lung function, but less is known about genes influencing longitudinal change in lung function.MethodsWe performed GWAS of the rate of change in forced expiratory volume in the first second (FEV1) in 14 longitudinal, population-based cohort studies comprising 27,249 adults of European ancestry using linear mixed effects model and combined cohort-specific results using fixed effect meta-analysis to identify novel genetic loci associated with longitudinal change in lung function. Gene expression analyses were subsequently performed for identified genetic loci. As a secondary aim, we estimated the mean rate of decline in FEV1 by smoking pattern, irrespective of genotypes, across these 14 studies using meta-analysis.ResultsThe overall meta-analysis produced suggestive evidence for association at the novel IL16/STARD5/TMC3 locus on chromosome 15 (P = 5.71 × 10-7). In addition, meta-analysis using the five cohorts with ≥3 FEV1 measurements per participant identified the novel ME3 locus on chromosome 11 (P = 2.18 × 10-8) at genome-wide significance. Neither locus was associated with FEV1 decline in two additional cohort studies. We confirmed gene expression of IL16, STARD5, and ME3 in multiple lung tissues. Publicly available microarray data confirmed differential expression of all three genes in lung samples from COPD patients compared with controls. Irrespective of genotypes, the combined estimate for FEV1 decline was 26.9, 29.2 and 35.7 mL/year in never, former, and persistent smokers, respectively.ConclusionsIn this large-scale GWAS, we identified two novel genetic loci in association with the rate of change in FEV1 that harbor candidate genes with biologically plausible functional links to lung function.

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A polymorphism in the promoter region of the human interleukin‐16 gene is not associated with asthma or atopy in an Australian population

Abstract: Although it has been hypothesized that the T(-295)C promoter polymorphism may be associated with increased IL-16 gene expression, it is not associated with asthma, disease severity or atopy in this Australian population.

Cited by 16 publications

References 21 publications

Gene susceptibility in iranian asthmatic patients: A narrative review

Gene susceptibility in iranian asthmatic patients: A narrative review

Association of asthma with a functional promoter polymorphism in the IL16 gene

Large-Scale Genome-Wide Association Studies and Meta-Analyses of Longitudinal Change in Adult Lung Function

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