A Polymorphism of the Renin Gene<i>rs6682082</i>Is Associated with Essential Hypertension Risk and Blood Pressure Levels in Korean Women

Park, Jong–Keun; Song, Keun Jeong; Jang, Yangsoo; Yoon, Sungjoo Kim

doi:10.3349/ymj.2015.56.1.227

Cited by 4 publications

(8 citation statements)

References 34 publications

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“…Both mutations are found in the intracellular cytoplasmic tail of the receptor, near the 7 th transmembrane region, which is a probable Gs-protein binding domain [ 19 , 27 ]. Renin, a protease expressed mostly in the kidney, hence catalyses the first and rate-limiting step of the RAS cascade, playing an important role in the control of blood pressure and electrolyte balance [ 28 ]. The REN gene is made up of 12 exons spread across 12 kb of human chromosome 1q32 [ 28 ].…”

Section: Introductionmentioning

confidence: 99%

PTPRD gene variant rs10739150: A potential game-changer in hypertension diagnosis

AL-Eitan

2024

PLoS ONE

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Background High blood pressure, also known as hypertension (HTN), is a complicated disorder that is controlled by a complex network of physiological processes. Untreated hypertension is associated with increased death incidence, rise the need for understanding the genetic basis affecting hypertension susceptibility and development. The current study sought to identify the genetic association between twelve single nucleotide polymorphisms (SNPs) within seven candidate genes (NOS3, NOS1AP, REN, PLA2G4A, TCF7L, ADRB1, and PTPRD) Methods The current study included 200 Jordanian individuals diagnosed with hypertension, compared to 224 healthy controls. Whole blood samples were drawn from each individual for DNA isolation and genotyping. The SNPStats tool was used to assess haplotype, genotype, and allele frequencies by the mean of chi-square (χ2). Results Except for rs10739150 of PTPRD (P = 0.0003), the genotypic and allelic distribution of the SNP was identical between patients and controls. The prevalence of the G/G genotype in healthy controls (45.5%) was lower than in hypertension patients (64.3%), suggesting that it might be a risk factor for the disease. PTPRD TTC genetic haplotypes were strongly linked with hypertension (P = 0.003, OR = 4.03). Conclusion This study provides a comprehensive understanding of the involvement of rs10739150 within the PTPRD gene in hypertension. This new knowledge could potentially transform the way we approach hypertension diagnosis, providing an accurate diagnostic tool for classifying individuals who are at a higher risk of developing this condition.

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Section: Introductionmentioning

confidence: 99%

PTPRD gene variant rs10739150: A potential game-changer in hypertension diagnosis

AL-Eitan

2024

PLoS ONE

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“…Moreover, studies on candidate-gene-based association are still very popular for identifying genetic components of EH. 3 …”

Section: Introductionmentioning

confidence: 99%

“…In 2010, Vangjeli et al 13 found that the REN-5312C/T polymorphism was associated with increased blood pressure in the Irish population. Park et al 3 suggested that carriers of the A allele in rs6682082 were more likely to have hypertension amongst Korean women. Another aspect of REN variation was insert/deletion ( I/D ).…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, studies on candidate-gene-based association are still very popular for identifying genetic components of EH. 3 Renin, as the first enzyme of the RAAS cascade, is an aspartyl protease synthesized by the juxtaglomerular cells of the kidney. Renin cleaves angiotensinogen to angiotensin I, which is further catalyzed to angiotensin II by ACE.…”

Section: Introductionmentioning

confidence: 99%

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Haplotype-based association of renin gene polymorphisms with essential hypertension in Han population of northern china

Zhang

et al. 2017

J Renin Angiotensin Aldosterone Syst

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Introduction:The renin gene has been suggested as a good candidate in the study of genetic mechanism of essential hypertension. However, studies on the contribution of renin gene polymorphisms to essential hypertension, have not had consistent outcomes. The purpose of the present study is to explore the association of renin gene polymorphisms with essential hypertension in the Han population of northern China.Methods:A case-control study was conducted among 3090 Han farmers (1533 essential hypertension patients and 1557 normotensives). Genotyping was performed by polymerase chain reaction-restriction fragment length polymorphism and polymerase chain reaction-sequencing.Results:The genotypic and allelic distributions of rs2368564 in essential hypertension and control was significant statistically (p<0.001). The allelic distribution of rs10900557 showed marginal statistical significance (p=0.048). There were no significant differences in other genotypic and allelic distributions (p>0.05). In the haplotypes comprised by the six single-nucleotide polymorphisms, there were differences in the distribution of haplotypes A-T-C-G-C-A, A-T-C-G-C-G, G-C-T-G-T-A and G-C-T-G-T-G in both groups, and their differences reached to significant levels, respectively. After having corrected for false discovery rate, this association still remained significant.Conclusions:The current study provides evidence for a possible association of renin gene polymorphisms with essential hypertension in a Han population of northern China.

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“…The REN single-nucleotide polymorphisms (SNPs) are found to be associated with risk of having the aforementioned diseases [5,6]. Some of these are studied in different populations such as Korea, Mexico, USA, and Europe [7,8]. rs5705 is an exonic synonymous variant whose frequency distribution is unavailable in Indian population.…”

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confidence: 99%

RENIN SINGLE-NUCLEOTIDE POLYMORPHISM (rs5705) IN HEALTHY INDIAN POPULATION

Varakantham

Venkata

Bharatraj

2018

Asian J Pharm Clin Res

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Objective: Renin gene (REN) polymorphisms are studied to understand its association with different diseases such as hypertension. The genetic variants have different frequencies in various populations. Therefore, we have established normal frequencies of rs5705 variants in healthy Indian population.Methods: The genotype and allele frequencies of rs5705 were determined in 324 healthy Indian population using real-time polymerase chain reaction.Results: Our study showed 91.7% T allele or TT genotype and 8.3% G allele or TG genotype. It is interesting to note that the minor allele (G) is found only in the form of heterozygous TG condition and the homozygous form GG was absent. These frequencies were compared with different populations.Conclusions: The significant variations found between our population and others confirm interethnic variations. Future studies may use our established genotype frequencies of rs5705 to understand the risk of diseases such as hypertension.

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A Polymorphism of the Renin Geners6682082Is Associated with Essential Hypertension Risk and Blood Pressure Levels in Korean Women

Cited by 4 publications

References 34 publications

PTPRD gene variant rs10739150: A potential game-changer in hypertension diagnosis

PTPRD gene variant rs10739150: A potential game-changer in hypertension diagnosis

Haplotype-based association of renin gene polymorphisms with essential hypertension in Han population of northern china

RENIN SINGLE-NUCLEOTIDE POLYMORPHISM (rs5705) IN HEALTHY INDIAN POPULATION

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