A polyphenol mixture from cinnamon targets p38 MAP kinase-regulated signaling pathways to produce G2/M arrest

Schoene, Norberta W.; Kelly, Meghan; Polansky, Marilyn M.; Anderson, Richard A.

doi:10.1016/j.jnutbio.2008.06.006

Cited by 24 publications

(16 citation statements)

References 29 publications

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“…Several researchers have shown that polyphenols inhibit p38 MAPK activity. Further, it is known that p38 MAPK is involved in apoptosis and stress response 41–43. It has been observed that in a skeletal muscle injury, p38 MAPK pathways are transiently upregulated via the tumor necrosis factor‐α in C2C12 cells 44, the human vastus lateralis muscle 45, and mouse soleus muscle 46, 47.…”

Section: Discussionmentioning

confidence: 99%

Dietary apple polyphenols have preventive effects against lengthening contraction‐induced muscle injuries

Nakazato

Ochi

Waga

2010

Molecular Nutrition Food Res

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We examined whether polyphenols from dietary apple have protective effects against exercise-induced muscle strain injury. Sixteen male Wistar rats were randomly assigned into the apple polyphenol (APP; N=8) and control (CON; N=8) groups. The APP and the CON groups were fed diets with and without 5% APP, respectively. After a 3-wk feeding period, the gastrocnemii of the animals were subject to lengthening contractions with electrical stimulation and forced ankle dorsiflexion. Isometric torques were measured before and after the lengthening contractions and on days 1, 2, 3, 5, and 7 after the contractions. On day 7, the animals were sacrificed and the gastrocnemii harvested. Thiobarbituric-acid-reactive substances, protein carbonyl, and mRNA of antioxidative proteins in the muscles were quantified. The APP group had significantly lower torque deficits than the CON group on days 3, 5, and 7 after the eccentric contractions. The thiobarbituric-acid-reactive substances and protein carbonyl levels in the case of the APP group were significantly lower than those in the case of the CON group. The APP group had significantly higher glutathione-S-transferase alpha1 mRNA levels than the CON group. Therefore, we conclude that dietary APPs have protective effects against lengthening contraction-induced muscle injury.

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Section: Discussionmentioning

confidence: 99%

Dietary apple polyphenols have preventive effects against lengthening contraction‐induced muscle injuries

Nakazato

Ochi

Waga

2010

Molecular Nutrition Food Res

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“…These Th-2 cells are important in switching antibody production from B cells to predominantly IgE production as well as secreting chemokines that attract allergic immune cells such as MC and eosinophils to inflammatory sites. Polyphenols such as catechins and their derivatives can inhibit the production of Th-2 cytokines [30][31][32][33] and impact on the activation, proliferation and recruitment status of T cells [34][35][36][37]. B cell recruitment to inflammatory sites and IgE production were also reported to be inhibited via polyphenol consumption [32,[38][39][40].…”

Section: Polyphenols Modulate Different Phases Of the Allergic Responsementioning

confidence: 99%

Dietary polyphenols in the prevention and treatment of allergic diseases

Singh

Holvoet

Mercenier

2011

Clin Experimental Allergy

200

148

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Allergic disorders encompass skin, food and respiratory allergies. Sensitization to a normally harmless allergen results in the immune system being biased to a predominant T-helper type 2 response. Re-exposure to the same allergen leads to a robust secretion of allergy-related mediators that eventually triggers symptoms. Our understanding of these disorders has enabled the search of therapeutic approaches that can either modulate the sensitization process or impact on allergic mediators, thus helping manage allergic symptoms. Polyphenols are one such class of compounds that are found in foods and plant sources and have been investigated for their anti-allergic effect in different disease models and in human clinical trials. Their anti-inflammatory profile is known to impact on the recruitment of immune cells to the skin and in preventing the development of secondary infections following disruption of the skin barrier. The interaction of polyphenols with proteins can modulate the process of allergic sensitization and their direct effect on allergic effector cells such as mast cells inhibit mediator release, resulting in the alleviation of symptoms. In addition, their endogenous anti-oxidant ability limits the extent of cellular injury from free radicals during the allergic insult. Overall, polyphenols hold promise as anti-allergy agents capable of influencing multiple biological pathways and immune cell functions in the allergic immune response and deserve further investigation. The objective of the current review is to summarize the key findings and progress made in studying polyphenols as anti-allergic ingredients. Special emphasis is placed in this review to highlight key physiological, cellular and signalling pathways implicated in the mechanism of action of different polyphenols in the context of allergic disorders and their manifestations.

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“…On the other hand, Cinnamon is potential to be developed as chemopreventive agent because it can be inhibitor of angiogenesis protein (Lu, et al, 2010). It also inhibits many cancer cells growth and induces G2/M phase arrest (Scoene, et al, 2008). Scientific research regarding anti-metastatic of these plants has never been done.…”

Section: Introductionmentioning

confidence: 99%

A Comparison of Antimetastatic Activity between Nerium indicum and Cinnamomum burmannii on 4T1 Cells

Lestari

Muntafiah

Walidah

et al. 2017

IJCC

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Metastatic process becomes a major problem in advanced cancer cases. Natural compounds found in several plants in Indonesia have a potency to be developed as chemoterapeutic agent which are targeted to metastatic process. Jure leaves (Nerium indicum) which contain oleandrin and cinnamaldehyde in cinnamon bark (Cinnamomum burmannii) reported to have cytotoxic activity on several cancer cells, but their activities on metastasic process have never been explored. This research aims to reveal and to compare their anti-metastatic effect toward 4T1 breast cancer cells. The cytotoxicity of jure leaves extract (JLE) and cinnamon essential oil (CEO) was obtained by MTT assay. Metastatic process mainly on cell migration was examined by scratch wound healing assay while MMP-9 expression that described the invassion process was observed by gelatin zymography assay. Molecular interaction between their active compounds and MMP-9 receptor was predicted by molecular docking. The result showed that treatment with JLE and CEO inhibited the growth of 4T1 cells with IC50 value of 125 µg/mL and 2.5 µg/mL, respectively. In addition, JLE performed inhibitory effect of cell migration better than CEO. Meanwhile, both JLE and CEO decreased MMP-9 protein expression. Thus, JLE and CEO have potentials to be developed as an anti-metastatic agent and JLE could be more effective.

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A polyphenol mixture from cinnamon targets p38 MAP kinase-regulated signaling pathways to produce G2/M arrest

Cited by 24 publications

References 29 publications

Dietary apple polyphenols have preventive effects against lengthening contraction‐induced muscle injuries

Dietary apple polyphenols have preventive effects against lengthening contraction‐induced muscle injuries

Dietary polyphenols in the prevention and treatment of allergic diseases

A Comparison of Antimetastatic Activity between Nerium indicum and Cinnamomum burmannii on 4T1 Cells

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