“…Although less frequent, Pseudomonas also have PKS-derived secondary metabolites, as is the case of the antibiotic mupirocin ( Figure 15 ) [ 364 , 365 , 366 ] or 2,4-Diacetylphloroglucinol (DAPG), a small molecule which can frequently be found in plant-associated Pseudomonas [ 333 , 367 , 368 , 369 ], as well as hybrid PKS-NRPS molecules such as the toxins pyoluteorin, syringolin or coronatine ( Figure 14 ) [ 326 , 370 , 371 , 372 ]. Interestingly, Pseudomonas is also the source of many secondary metabolites with non PKS or NRPS biosynthetic origins, such as the highly diverse and versatile phenazines, which can act as antimicrobials, siderophores and redox acceptors among other functions [ 373 , 374 , 375 ], the phytohormone Indole-3-acetic acid, hydrogen cyanide [ 333 , 376 ], the recently discovered anti-algal polyyne toxin protegencin ( Figure 15 ) [ 377 , 378 ] or the novel pyonitrins ( Figure 15 ), which are the product of spontaneous condensation of two previously known natural products, pyochelin and pyrrolnitrin, just to name a few [ 379 ]. It is in this area, the less easily identified BGCs, where Pseudomonas exhibit big potential for novel chemistry discovery.…”