A Pooled Analysis of Bladder Cancer Case–Control Studies Evaluating Smoking in Men and Women

Puente, Diana; Hartge, Patricia; Greiser, Eberhard; Cantor, Kenneth P.; King, Will D.; González, Carlos; Cordier, Sylvaine; Víneis, Paolo; Lynge, Elsebeth; Chang‐Claude, Jenny; Porru, Stefano; Τζώνου, Αναστασία; Jöckel, Karl Heinz; Serra, Consol; Hours, Martine; Lynch, Charles F.; Ranft, Ulrich; Wahrendorf, Jürgen; Silverman, Debra T.; Fernández, Francisco Pedro García; Boffetta, Paolo; Kogevinas, Manolis

doi:10.1007/s10552-005-0389-0

Cited by 36 publications

(25 citation statements)

References 39 publications

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“…25,26 Previous studies have found PARs of 50-65% in men and 20-30% in women but were conducted in populations where the prevalence of smoking in women was considerably lower than in men. [27][28][29][30][31] Renal impairment was also an important issue in the timely management of the NMIBC population in this part of the world as suggested by the presented data. Up to 40% of patients with bladder cancer have renal impairment, defined as a creatinine clearance ≤60 ml/min, as calculated by the Cockroft-Gault formula.…”

Section: Discussionmentioning

confidence: 99%

Single center experience of urinary bladder malignancy: a 10-year retrospective analysis of hospital data

et al. 2017

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INTRODUCTIONAlbeit the EAU, NCCN and AUA guidelines provide an excellent evidence-based protocol for the management of MIBC and NMIBC, these guidelines differ with respect to critical issues such as risk level definitions and management strategies. Implication of the aforementioned treatment policy in a vast subcontinent like ours has always been a challenge. The NE part of the country has always bore the brunt of heavy Oncological catastrophe like urinary bladder carcinoma related to extensive tobacco and pesticide usage. MIBC treatment usually encompasses radical cystectomy (RC) with adjuvant chemotherapy (AC)/ neo-adjuvant ABSTRACT Background: Albeit the EAU, NCCN and AUA guidelines provide an excellent evidence-based protocol for the management of MIBC and NMIBC, these guidelines differ with respect to critical issues such as risk level definitions and management strategies. The NE part of the country has always bore the brunt of heavy oncological catastrophe like urinary bladder carcinoma related to extensive tobacco and pesticide usage. MIBC treatment usually encompasses RC with AC/NAC (Level I evidence for NAC use in MIBC exist) but the majority of patients seen at our center have already progressed to advanced stage at presentation and could not undertake full treatment. Methods: Cancer registry of the last 10 yrs at Dept. of Urology and Renal Transplant Gauhati Medical College Hospital was searched for demographic, clinical, pathological and prognostic data and results summarized using statistical parameters of univariate analysis.Results: There were a total of 168 patients in the NMIBC group with a majority in the 60-70-year age group. The most common grade was G2 and all DM type 2 and CKD were significantly associated in all the patients analyzed.Chemical exposure in the form of pesticide and smoking was a constant phenomenon in all patients of NMIBC and MIBC (n=66) population. CKD was significantly associated in the MIBC population along with positive urine cytology. Conclusions: Despite a paucity of high level evidence regarding the majority of management topics in Urinary Bladder cancer in NE part of the country, there was general agreement among the various guideline panels and management guidelines at our institution. Identification of the upfront clinical parameters suggesting severity of disease and time to progression are the two most important domains which will decide the future of UB carcinoma treatment in this part of the world. Categories of evidence synthesized and grades of recommendations will have to be constantly gazed upon to modify and enhance treatment strategies.

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Section: Discussionmentioning

confidence: 99%

Single center experience of urinary bladder malignancy: a 10-year retrospective analysis of hospital data

et al. 2017

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“…19 Epidemiologically, postmenopausal women have a higher risk of development and progression of UBC than premenopausal women. 20 Also, smoking is one of the major risks of urinary tract cancer and considered to increase the cancer risk by approximately threefold, 21,22 and the percentage of smokers is much higher in males than in females in Japan (36.8 versus 9.1%, as of 2008 in the National Survey by the Ministry of Health, Labour and Welfare of Japan). If such environmental and life style-related factors contribute to the predisposition of bladder cancer together with POLG2, this may explain the observed effect of POLG2 with UBC invasiveness in males only.…”

Section: Discussionmentioning

confidence: 99%

A polymorphism of the POLG2 gene is genetically associated with the invasiveness of urinary bladder cancer in Japanese males

et al. 2011

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Urinary bladder cancer (UBC) is a common cancer with male predominance. Pathologically it is classified into two distinct tumor entities related to the risk of patients. The low-grade tumors with relatively well-differentiated tumor histology (G1 and G2) at stage Ta are non-invasive and pose a minimal risk, whereas high-grade tumors (G2 and G3) with stages T1 to T4 are aggressive with invasion, and therefore, pose a serious risk for the patients. DNA repair and metabolic process genes may have major roles in cancer progression and development. To identify genes associated with invasiveness of UBC, we have extensively genotyped 802 single nucleotide polymorphisms in 114 genes related to DNA repair mechanisms and metabolic processes. A genetic association study was performed between non-invasive (G1 and G2 with Ta) and invasive (G2 and G3 with T1 to T4) groups of Japanese UBC patients. We found that rs17650301 in POLG2 showed marked difference in genotype distribution between the two groups in males (P¼6.93Â10 À4 ), which was further confirmed in an independent sample set (overall P¼1.67Â10 À4 ). We also found by an in silico analysis that the risk allele of rs17650301 increased the transcription of POLG2. In conclusion, rs17650301 is a good candidate marker for UBC invasiveness in Japanese males.

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“…Additional cases from the NIC members enhanced stability of the background rates of urothelial carcinoma incidence. For those who smoked, cross-tabulation included timevarying levels of intensity (cut points at: 3,8,13,18,23,33,43. cigarettes/day), duration of smoking, and years since quitting (cut points at: 5, 10, 20, 30. years).…”

Section: Statistical Analysesmentioning

confidence: 99%

“…Numerous epidemiological studies have reported associations between ionizing radiation (IR) exposure and bladder cancer (1)(2)(3)(4)(5)(6), while others have reported associations between lifestyle factors and bladder cancer, particularly smoking (7)(8)(9)(10)(11). In the most recent cancer incidence report on the Life Span Study (LSS) of A-bomb survivors, the urinary bladder had the highest excess relative risk (ERR) per unit dose of radiation of any of the solid cancers other than the female breast (ERR/gray weighted bladder dose ¼ 1.23) (1).…”

Section: Introductionmentioning

confidence: 99%

“…Lifestyle factors reported to be clearly associated with bladder cancer include smoking (7,8), occupational exposures to certain chemicals, particularly aromatic amines (9,10), and excessive use of certain analgesics (24). Tobacco from cigarettes is the most common factor in the occurrence of excess bladder cancer, accounting for 30-50% of all cases, with a relative risk of 2-3 for smokers compared to nonsmokers (17,18).…”

Section: Introductionmentioning

confidence: 99%

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Effects of Radiation and Lifestyle Factors on Risks of Urothelial Carcinoma in the Life Span Study of Atomic Bomb Survivors

Grant

Ozasa

Preston³

et al. 2012

Radiation Research

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A Pooled Analysis of Bladder Cancer Case–Control Studies Evaluating Smoking in Men and Women

Abstract: These results do not support the hypothesis that women have a higher relative risk of smoking-related bladder cancer than men.

Cited by 36 publications

References 39 publications

Single center experience of urinary bladder malignancy: a 10-year retrospective analysis of hospital data

Single center experience of urinary bladder malignancy: a 10-year retrospective analysis of hospital data

A polymorphism of the POLG2 gene is genetically associated with the invasiveness of urinary bladder cancer in Japanese males

Effects of Radiation and Lifestyle Factors on Risks of Urothelial Carcinoma in the Life Span Study of Atomic Bomb Survivors

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