A Popular myth – low‐histamine diet improves chronic spontaneous urticaria – fact or fiction?

Wagner, Nicola; Dirk, Desiree R.; Peveling‐Oberhag, Adriane; Reese, Imke; Rady-Pizarro, U; Mitzel, H; Staubach, Petra

doi:10.1111/jdv.13966

Cited by 70 publications

(75 citation statements)

References 29 publications

(65 reference statements)

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“…In some CSU patients, pseudo‐allergic reactions (non‐IgE‐mediated hypersensitivity reactions) to naturally occurring food ingredients and in some cases to food additives have been observed . A pseudoallergen‐free diet, containing only low levels of natural as well as artificial food pseudoallergens, has been tested in different countries and also a low histamine diet may improve symptoms in those patients . Those diets are controversial and as yet unproven in well‐designed double‐blind placebo‐controlled studies.…”

Section: Management Of Urticariamentioning

confidence: 99%

The EAACI/GA²LEN/EDF/WAO guideline for the definition, classification, diagnosis and management of urticaria

Zuberbier

Aberer

Asero

et al. 2018

Allergy

Self Cite

1,368

1,953

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This evidence- and consensus-based guideline was developed following the methods recommended by Cochrane and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) working group. The conference was held on 1 December 2016. It is a joint initiative of the Dermatology Section of the European Academy of Allergology and Clinical Immunology (EAACI), the EU-founded network of excellence, the Global Allergy and Asthma European Network (GA²LEN), the European Dermatology Forum (EDF) and the World Allergy Organization (WAO) with the participation of 48 delegates of 42 national and international societies. This guideline was acknowledged and accepted by the European Union of Medical Specialists (UEMS). Urticaria is a frequent, mast cell-driven disease, presenting with wheals, angioedema, or both. The lifetime prevalence for acute urticaria is approximately 20%. Chronic spontaneous urticaria and other chronic forms of urticaria are disabling, impair quality of life and affect performance at work and school. This guideline covers the definition and classification of urticaria, taking into account the recent progress in identifying its causes, eliciting factors and pathomechanisms. In addition, it outlines evidence-based diagnostic and therapeutic approaches for the different subtypes of urticaria.

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Section: Management Of Urticariamentioning

confidence: 99%

The EAACI/GA²LEN/EDF/WAO guideline for the definition, classification, diagnosis and management of urticaria

Zuberbier

Aberer

Asero

et al. 2018

Allergy

Self Cite

1,368

1,953

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“…38 It is interesting that it is impossible to predict whether a patient will benefit from avoiding histamine in his diet based on clinical history (daily symptoms, previous experience of tolerating or not tolerating histamine-rich foods) or the initial level of diamine oxidase activity. 38,39 Because of the differing diets and eating habits across the world, it is important to remember that success rates may vary greatly. More research is needed to determine the effect of natural and artificial ingredients of food on urticaria.…”

Section: Intolerance Urticariamentioning

confidence: 99%

Urticaria in children and adolescents: An updated review of the pathogenesis and management

Kudryavtseva

Нескородова

Staubach

2018

Pediatric Allergy Immunology

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The present survey represents the latest data on diagnosis and management of childhood urticaria. It has been observed that urticaria occurs less often in children than adults, with symptoms rarely lasting for over 6 weeks. Triggers or aggravating factors can be found only in 21%-55% of cases. Finding autoantibodies in children does not impact a disease prognosis, unlike in adult patients, where the presence of autoantibodies is associated with a more prolonged run of the disease, a more severe prognosis and more intensive treatment methods. The incidence of food allergy equals to 8%-10% of cases. The incidence of Helicobacter Pylori infection in children is lower than that in adults and comes to 10%-18%. Medical experts recommend using the same treatment schemes for adults and children. This survey describes different urticaria management patterns suggested by experts from Europe, America, and Russia in their recent guidelines. It has been noted that unlike the guidelines from 2014, the 2018 clinical practice guidelines for the diagnosis and management of urticarial once again suggest a four-step treatment scheme with assigning omalizumab for Step 3 and cyclosporine A for Step 4 in the event of low therapeutic efficacy of the previous step or its impossibility. Leukotriene antagonists (LTRAs) are currently removed from basic management to alternative programs.

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“…hDAO has a central role in histamine intolerance, which is caused by histamine-rich food, alcohol, or drugs that release histamine or inhibit hDAO and, thus, leads to an excess of histamine and symptoms similar to an allergic reaction in the patients [26]. hDAO deficiency has been described in patients with atopic eczema, chronic urticaria, chronic abdominal pain or inflammatory bowel disease, migraines, and asthma [94][95][96][97][98][99]. Histamine also induces contractions and spontaneous abortions when injected into pregnant animals [28,[100][101][102].…”

Section: Biological Functionmentioning

confidence: 99%

Human Copper-Containing Amine Oxidases in Drug Design and Development

et al. 2020

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Two members of the copper-containing amine oxidase family are physiologically important proteins: (1) Diamine oxidase (hDAO; AOC1) with a preference for diamines is involved in degradation of histamine and (2) Vascular adhesion protein-1 (hVAP-1; AOC3) with a preference for monoamines is a multifunctional cell-surface receptor and an enzyme. hVAP-1-targeted inhibitors are designed to treat inflammatory diseases and cancer, whereas the off-target binding of the designed inhibitors to hDAO might result in adverse drug reactions. The X-ray structures for both human enzymes are solved and provide the basis for computer-aided inhibitor design, which has been reported by several research groups. Although the putative off-target effect of hDAO is less studied, computational methods could be easily utilized to avoid the binding of VAP-1-targeted inhibitors to hDAO. The choice of the model organism for preclinical testing of hVAP-1 inhibitors is not either trivial due to species-specific binding properties of designed inhibitors and different repertoire of copper-containing amine oxidase family members in mammalian species. Thus, the facts that should be considered in hVAP-1-targeted inhibitor design are discussed in light of the applied structural bioinformatics and structural biology approaches.

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A Popular myth – low‐histamine diet improves chronic spontaneous urticaria – fact or fiction?

Abstract: Low-histamine diet is a therapeutically useful, simple and cost-free tool to decrease symptoms and increase quality of life in CsU patients with gastrointestinal involvement. Further research is needed to understand the role of diamine oxidase.

Cited by 70 publications

References 29 publications

The EAACI/GA²LEN/EDF/WAO guideline for the definition, classification, diagnosis and management of urticaria

The EAACI/GA²LEN/EDF/WAO guideline for the definition, classification, diagnosis and management of urticaria

Urticaria in children and adolescents: An updated review of the pathogenesis and management

Human Copper-Containing Amine Oxidases in Drug Design and Development

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