A population-based case-control study of the familial risk of abdominal aortic aneurysm

Larsson, Emma; Granath, Fredrik; Swedenborg, Jesper; Hultgren, Rebecka

doi:10.1016/j.jvs.2008.08.012

Cited by 157 publications

(101 citation statements)

References 17 publications

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“…20 A populationbased study in Sweden using national registries found that the relative risk of AAA for the firstdegree relatives of both male and female AAA patients was similar. 22 …”

Section: Human Aaa Studies Risk Factors For Aaa In Men and Womenmentioning

confidence: 99%

Sex Differences in Abdominal Aortic Aneurysm: The Role of Sex Hormones

Makrygiannis

Courtois

Drion

et al. 2014

Annals of Vascular Surgery

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Abdominal aortic aneurysm (AAA) is a complex multifactorial disease with genetic and environmental components. AAA is more common in men, whereas women have a greater risk of rupture and more frequently have concomitant thoracic aortic aneurysms. Moreover, women are diagnosed with AAA about 10 years later and seem to be protected by female sex hormones. In this MEDLINE-based review of literature, we examined human and animal in vivo and in vitro studies to further deepen our understanding of the sexual dimorphism of AAA. We focus on the role of sex hormones during the formation and growth of AAA. Endogenous estrogens and exogenous 17b-estradiol were found to exert favorable actions protecting from AAA in animal models, whereas exogenous hormone replacement therapy in humans had inconclusive results. Androgens, known to have detrimental effects in the vasculature, in sufficient levels maintain the integrity of the aortic wall through their anabolic actions and act differentially in men and women, whereas lower levels of testosterone have been associated with AAA in humans. In conclusion, sex differences remain an important area of AAA research, but further studies especially in humans are needed. Furthermore, differential molecular mechanisms of sex hormones constitute a potential therapeutic target for AAA.

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“…20 A populationbased study in Sweden using national registries found that the relative risk of AAA for the firstdegree relatives of both male and female AAA patients was similar. 22 …”

Section: Human Aaa Studies Risk Factors For Aaa In Men and Womenmentioning

confidence: 99%

Sex Differences in Abdominal Aortic Aneurysm: The Role of Sex Hormones

Makrygiannis

Courtois

Drion

et al. 2014

Annals of Vascular Surgery

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“…5,6,[9][10][11] A review of observational studies on the risk of AAA among smokers 53 indicated that smokers have a higher risk of AAA than never smokers; current smokers have a higher risk of developing AAA than former smokers; and those who smoke more than 20 cigarettes a day have a higher risk of AAA than those who smoke less. In relation to growth and rupture of an AAA, a meta-analysis conducted by the RESCAN collaboration 54 found that current smoking has a modest impact on growth of an AAA and doubles the risk of rupture.…”

Section: Considerations For Implementationmentioning

confidence: 99%

“…7,8 Other risk factors for the development of an AAA include advanced age 9 and family history of AAA. 10,11 Coronary artery disease, atherosclerosis, hypercholesterolemia and hypertension have weaker associations with AAA. 8,12 Patients with diabetes appear less likely to develop AAA.…”

mentioning

confidence: 99%

Recommendations on screening for abdominal aortic aneurysm in primary care

2017

CMAJ

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KEY POINTS• Pooled analyses from four population-based RCTs with men older than 65 years show that one-time screening with ultrasonography for AAA reduces the risk of aneurysm-related death, rupture and emergency repair.• Screening leads to identification of aneurysms that would not dilate or rupture, and increases the likelihood of elective repair procedures for these patients.• A weak recommendation in favour of screening suggests the importance of shared decision-making with the primary care provider and patient, with discussion of patient preferences for screening.• The prevalence of AAA in screened populations has declined since the RCTs were conducted, reducing the absolute benefit of screening.• Women have much lower rates of AAA than men, and there is no direct evidence that screening women has a positive impact on their health.• Evidence on the impact of AAA screening on men older than 80 years of age is indirect, meaning any potential benefit is uncertain. CPD

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“…Data from a Swedish population study demonstrated that a family history of AAA increased the risk of AAA about 2 fold, (Larsson et al, 2009). Although the benefits of screening for AAA in the presence of a family history of aneurysm has not been formally assessed, (Moll et al, 2011).…”

Section: Family Historymentioning

confidence: 99%

Abdominal aortic aneurysms

Atkin

Orsouw

2016

Independent Nurse

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Abdominal Aortic Aneursym (AAA) is an enlargement of the aorta. The aorta is the main artery that runs from the heart suppling oxygented blood to all the major organs. AAA tended only to be found by coincIndence when patients underwent some form of imaging, although in many cases AAA went AAA -what is it?An aneurysm is an area of localised enlargement or dilation of a blood vessel. The word aneurysm comes from the Greek work aneurysma which means 'a widening'. The aorta originates from the left ventricle of the heart and it extends through the chest down into the abdomen splitting at the level of the fourth lumbar vertebrae into the common iliac arteries. The aorta is classed in anatomical compartments: thoracic aorta (from the heart to the diaphragm), and abdominal aorta

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A population-based case-control study of the familial risk of abdominal aortic aneurysm

Abstract: In this nationwide survey, the relative risk of developing AAA for first-degree relatives to persons diagnosed with AAA was approximately doubled compared to persons with no family history. Neither the gender of the index person nor the first-degree relative influenced the risk of AAA.

Cited by 157 publications

References 17 publications

Sex Differences in Abdominal Aortic Aneurysm: The Role of Sex Hormones

Sex Differences in Abdominal Aortic Aneurysm: The Role of Sex Hormones

Recommendations on screening for abdominal aortic aneurysm in primary care

Abdominal aortic aneurysms

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