A Population-Based, Cross-Sectional Comparison of Lipid-Related Indexes for Symptoms of Atherosclerotic Disease

Lipoprotein ratios are better than conventional lipid parameters in predicting coronary heart disease in Chinese Han people

“…However, there are more and more arguments among epidemiologists and clinicians that coronary risk assessment based exclusively on LDL-C is not optimal, particularly in individuals at intermediate risk [4][5][6]. Efforts have been made in seeking emergent or new cardiovascular risk markers to improve CHD prediction.…”

“…The ratios can comprehensively reflect the balance between the atherogenic and antiatherogenic potentials in an individual. There is growing evidence that the HDL-C related ratios, including TC/HDL-C, LDL-C/HDL-C, non-HDL-C/HDL-C, VLDL-C/HDL-C, and TG/HDL-C, are superior to conventional lipid parameters as predictors for CHD [6][7][8]. These ratios can provide more information on risk that is difficult to quantify by routine analyses and could be a better mirror of the metabolic and clinical interactions between lipid fractions.…”

Lipoprotein ratios: Physiological significance and clinical usefulness in cardiovascular prevention

“…47 The beneficial use of these indices as important cardiovascular risk predictors is based on multiple epidemiological studies which have shown that these ratios (total/HDL cholesterol and LDL/HDL cholesterol) have a greater correlation with cardiovascular disease and are therefore better predictors of cardiovascular disease than simple lipid parameters. 5,31,48 A study in 32,826 menopausal women 49 with an eight-year follow-up, after adjusting for age, smoking, C-reactive protein levels, homocysteine, body mass index, family history, diabetes, hypertension, physical activity, and alcohol consumption, found a relative risk of cardiovascular disease (95% CI) of 0.6 (0.5-0.8) for HDL cholesterol; 1.3 (1.0-1.5) for triglyceride levels; 1.4 (1.1-1.7) for LDL cholesterol; 1.7 (1.4-2.1) for apoB concentration; 1.6 (1.3-1.9) for non-HDL cholesterol; 1.5 (1.3-1.9) for the LDL/HDL cholesterol index; and 1.6 (1.3-1.9) for the total/HDL cholesterol index.…”

Atherogenic ratios in patients with recurrent acute coronary syndrome and receiving statin therapy: Clinical usefullness as cardiovascular predictors

“…Although low-density lipoprotein cholesterol (LDLc) is the traditional marker for cardiovascular risk and monitoring of statin therapy, it has been emphasized that cardiovascular disease management based exclusively on this lipid parameter might not be sufficient [2,3]. For this reason, therapeutic guidelines, though based on LDLc as the principal target of lipid-lowering therapy, also consider other lipid factors like non HighDensity Lipoprotein cholesterol (HDLc), apoprotein (apo) B, apo A-I and the total cholesterol (TC)/HDLc, some of which can be better predictors of cardiovascular risk than LDLc alone [4,5]. However, debate on the choice of the best lipid parameter has intensified, with apparently conflicting evidence among prospective studies [6][7][8].…”