A population-based cross-sectional study of colorectal cancer screening practices of first-degree relatives of colorectal cancer patients

Courtney, Ryan J.; Paul, Christine; Carey, Mariko; Sanson‐Fisher, Rob; Macrae, Finlay; DʼEste, Catherine; Hill, David; Barker, Daniel; Simmons, Jody

doi:10.1186/1471-2407-13-13

Cited by 65 publications

(51 citation statements)

References 52 publications

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“…A TOPflash reporter assay was performed in the cells (and APC -mutant SW480 colorectal cancer cells as a positive control) to assess the level of β-catenin/TCF-mediated transcriptional activity. In agreement with previous studies from our laboratory using mammary-derived epithelial and tumor cells (Prosperi et al, 2009; Odenwald et al, 2013), APC knockdown was insufficient to activate reporter activity above baseline (normalized to the activity observed in cells transfected with a mutant FOPflash reporter) (Figure 4A). These findings are also consistent with a lack of cytosolic or nuclear β-catenin accumulation observed in APC-knockdown MDCK cells (data not shown) and failure of APC knockdown in HC11 cells (described earlier) to demonstrate TOPflash reporter activity (data not shown).…”

Section: Resultssupporting

confidence: 92%

The APC tumor suppressor is required for epithelial cell polarization and three-dimensional morphogenesis

Lesko

Goss

Yang

et al. 2015

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

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The Adenomatous Polyposis Coli (APC) tumor suppressor has been previously implicated in the control of apical-basal polarity; yet, the consequence of APC loss-of-function in epithelial polarization and morphogenesis has not been characterized. To test the hypothesis that APC is required for the establishment of normal epithelial polarity and morphogenesis programs, we generated APC-knockdown epithelial cell lines. APC depletion resulted in loss of polarity and multi-layering on permeable supports, and enlarged, filled spheroids with disrupted polarity in 3D culture. Importantly, these effects of APC knockdown were independent of Wnt/β-catenin signaling, but were rescued with either full-length or a carboxy (c)-terminal segment of APC. Moreover, we identified a gene expression signature associated with APC knockdown that points to several candidates known to regulate cell-cell and cell-matrix communication. Analysis of epithelial tissues from mice and humans carrying heterozygous APC mutations further support the importance of APC as a regulator of epithelial behavior and tissue architecture. These data also suggest that the initiation of epithelial-derived tumors as a result of APC mutation or gene silencing may be driven by loss of polarity and dysmorphogenesis.

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Section: Resultssupporting

confidence: 92%

The APC tumor suppressor is required for epithelial cell polarization and three-dimensional morphogenesis

Lesko

Goss

Yang

et al. 2015

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

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“…Research on the influence of family history of cancer and screening behavior within ethnically diverse populations has been less consistent than would be expected given the connection between family history and personal cancer risk [13,32–36]. We found that participants with a family history of cancer were nearly twice as likely to report screening use, but this association was most pronounced in African Americans and US born-Latinos.…”

Section: Discussioncontrasting

confidence: 54%

Ethnic differences and predictors of colonoscopy, prostate-specific antigen, and mammography screening participation in the multiethnic cohort

Harmon

Little

Woekel

et al. 2014

Cancer Epidemiology

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Purpose Given the relation between screening and improved cancer outcomes and the persistence of ethnic disparities in cancer mortality, we explored ethnic differences in colonoscopy, prostate-specific antigen (PSA), and mammography screening in the Multiethnic Cohort Study. Methods Logistic regression was applied to examine the influence of ethnicity as well as demographics, lifestyle factors, comorbidities, family history of cancer, and previous screening history on self-reported screening participation collected in 1999–2002. Results The analysis included 140,398 participants who identified as white, African American, Native Hawaiian, Japanese American, US born-Latino, or Mexican born-Latino. The screening prevalences overall were mammography: 88% of women, PSA: 45% of men, and colonoscopy: 35% of men and women. All minority groups reported 10–40% lower screening utilization than whites, but Mexican-born Latinos and Native Hawaiian were lowest. Men were nearly twice as likely to have a colonoscopy (OR = 1.94, 95% CI = 1.89–1.99) as women. A personal screening history, presence of comorbidities, and family history of cancer predicted higher screening utilization across modalities, but to different degrees across ethnic groups. Conclusions This study confirms previously reported sex differences in colorectal cancer screening and ethnic disparities in screening participation. The findings suggest it may be useful to include personal screening history and family history of cancer into counseling patients about screening participation.

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“…An Australian study reported sibling with high level of education and income also private insurance are more volunteer to participate (25).…”

Section: Discussionmentioning

confidence: 99%

Participation Rate and Related Factors in Colonoscopy Screening Program in First-Degree Relatives of Patients Affected by Colorectal Cancer

et al. 2016

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Background: First-degree relatives (FDRs) of people diagnosed with colorectal cancer (CRC) have a two-to three-fold increased risk of developing disease. Colonoscopy screening test can be effective in prevention and early treatment. Objectives: The purpose of this study was to determine the rate of participation in colonoscopy screening test and related factors in first degree relatives. Methods: 200 FDRs of CRC cases were interviewed by the researchers. A reliable and valid questionnaire about undergoing colonoscopy screening test and barriers was filled via phone. To report qualitative data results, we used percent and proportion. Full (bytotal variables) and final (Forward LR) multiple logistic regression analysis were used to make a model which was executed using spss19. Results: In total, 59% FDRs had undergone colonoscopy screening test to the time of interview. Major reasons for not participating were fear of pain (23%), concerns about complications and test positive result (21.5%), lack of health insurance (21.5%), not believing in the test effectiveness (17%), no need because of healthy feeling (13%), embarrassment (12%) and distrust to service provider skills (10%). Results of multiple logistic regression analysis indicated there is statistical significance between participating colonoscopy screening and variables "not affected with hypertension (95%CI: 0.4 -2.04, OR = 3.7), believe in test effectiveness in FDRs (95%CI: 1.8 -16.9, OR = 5.6), also age of

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A population-based cross-sectional study of colorectal cancer screening practices of first-degree relatives of colorectal cancer patients

Cited by 65 publications

References 52 publications

The APC tumor suppressor is required for epithelial cell polarization and three-dimensional morphogenesis

The APC tumor suppressor is required for epithelial cell polarization and three-dimensional morphogenesis

Ethnic differences and predictors of colonoscopy, prostate-specific antigen, and mammography screening participation in the multiethnic cohort

Participation Rate and Related Factors in Colonoscopy Screening Program in First-Degree Relatives of Patients Affected by Colorectal Cancer

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