A Population Based Study of the Changing Demographics of Patients Undergoing Definitive Treatment for Kidney Stone Disease

Ordon, Michael; Urbach, David R.; Mamdani, Muhammad; Saskin, Refik; Honey, R. John D'a.; Pace, Kenneth T.

doi:10.1016/j.juro.2014.09.096

Cited by 48 publications

(27 citation statements)

References 22 publications

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“…Certainly, the lifetime prevalence of urolithiasis has historically been reported at 10% [2] ; these current data put that figure at closer to 14%, meaning roughly 1 in 7 of the population will require a hospital-based intervention for urolithiasis. Similar trends of increased intervention for urolithiasis has also been demonstrated in a Canada-based study, which demonstrated a 48% increase in patients undergoing kidney stone procedures between 1991 and 2010 [11] . It must be noted that the prevalence data are based on FCEs, and one patient may have had multiple FCEs over a year and therefore, these estimates will vary.…”

Section: Findings Of Our Studysupporting

confidence: 74%

Trends in Upper Tract Stone Disease in England: Evidence from the Hospital Episodes Statistics Database

Rukin

Siddiqui²,

Chedgy³

et al. 2016

Urol Int

143

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Aims: The study aimed to determine the current trends in urolithiasis-related admissions and associated interventions in England between 2006/2007 and 2013/2014 utilizing Hospital Episode Statistics (HES) online data. Material and Methods: Data was extracted from the online HES data set for each year from 2006/2007 to 2013/2014 inclusive. Admissions and procedural interventions were identified from their corresponding OPCS-4 and ICD-10 codes. Results: Finished consultant episodes (FCEs) for urolithiasis have increased by 20% over the last 7 years, with 93,039 FCEs in the year 2013/2014. Based on English population statistics, the lifetime prevalence of urolithiasis based on hospital-related admission/intervention data for 2013/2014 is 14%. The biggest increases were seen in those aged ≥75 years (up by 51%, n = 2,853). Total interventions have increased from 28,624 to 42,068, with increased rates of shock wave lithotripsy (26%), ureteroscopy (URS; 86%) and percutaneous nephrolithotomy (149%). Emergency URS procedures have increased by 38%. Day-case rates for ureteric and renal URS, in 2013/2014, were 22 and 21%, respectively. Conclusions: Over the last 7 years, there is a rising prevalence of kidney stone disease with associated increase in the number of interventions related to it. Both elective and emergency URS procedures are increasing, with a rising trend for day-case URS. Similar trends are seen worldwide and future resource planning for urolithiasis is needed to match the increase in demand.

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Section: Findings Of Our Studysupporting

confidence: 74%

Trends in Upper Tract Stone Disease in England: Evidence from the Hospital Episodes Statistics Database

Rukin

Siddiqui²,

Chedgy³

et al. 2016

Urol Int

143

View full text Add to dashboard Cite

show abstract

“…32). In Canada, a 48% increase in stone treatment between 1991 and 2010 was primarily accounted for by an increase in procedures among women 33 . The reason for the surge in stone disease in women is not precisely understood, but some have speculated that it might be attributable to changes in lifestyle and diet, resulting in increased obesity among women, a known risk factor for stone formation 30 .…”

Section: Epidemiologymentioning

confidence: 99%

Kidney stones

Khan

Pearle

Robertson

et al. 2016

Nat Rev Dis Primers

743

505

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Kidney stones are mineral deposits in the renal calyces and pelvis that are found free or attached to the renal papillae. They contain crystalline and organic components and are formed when the urine becomes supersaturated with respect to a mineral. Calcium oxalate is the main constituent of most stones, many of which form on a foundation of calcium phosphate called Randall’s plaques, which are present on the renal papillary surface. Stone formation is highly prevalent, with rates of up to 14.8% and increasing, and a recurrence rate of up to 50% within the first 5 years of the initial stone episode. Obesity, diabetes, hypertension and metabolic syndrome are considered risk factors for stone formation, which, in turn, can lead to hypertension, chronic kidney disease and end-stage renal disease. Management of symptomatic kidney stones has evolved from open surgical lithotomy to minimally invasive endourological treatments leading to a reduction in patient morbidity, improved stone-free rates and better quality of life. Prevention of recurrence requires behavioural and nutritional interventions, as well as pharmacological treatments that are specific for the type of stone. There is a great need for recurrence prevention that requires a better understanding of the mechanisms involved in stone formation to facilitate the development of more-effective drugs.

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“…Most epidemiologic studies of symptomatic urolithiasis in adults also show a male preponderance [29, 30]. …”

Section: Discussionmentioning

confidence: 99%

Epidemiology of paediatric renal stone disease: a 22-year single centre experience in the UK

et al. 2017

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BackgroundWhilst still rare, the incidence of paediatric stone disease is increasing in developed countries and it is important to evaluate the aetiology. We set up a dedicated renal stone service for children combining medical and surgical expertise in 1993 and now have a large case series of children to investigate the epidemiology.MethodsA retrospective hospital note review of children presenting with kidney stones during the last 22 years (1993–2015) was conducted. All patients had a comprehensive infective and metabolic screen and were classified as metabolic, infective or idiopathic stone disease.ResultsFive hundred eleven patients (322 male) were reviewed. The median age of presentation was 4.4y for males (1 m-16.6y) and 7.3y (1–18.5y) for females with a median height and weight on the 25th centile for male and on 10th and 25th for female, respectively. One hundred seventy five (34%) had an underlying metabolic abnormality, 112 (22%) had infective stones and 224 (44%) were classified as idiopathic.Of the 175 patients with a metabolic abnormality: 91 (52%) had hypercalciuria (76 persistent and 15 transient), 37 (21%) hyperoxaluria, 38 (22%) cystinuria, 3 (2%) abnormalities in the purine metabolism and the remainder other metabolic abnormalities. Bilateral stones occurred in 27% of the metabolic group compared to 16% in the non-metabolic group (OR 0.2, p < 0.05). Urinary tract infection was a common complication (27%) in the metabolic group.ConclusionsIn this paper, we present the largest cohort of paediatric stone disease reported from a developed country giving details on both, clinical and laboratory data. We show that in the majority of the patients there is an identifiable underlying metabolic and/or infective aetiology emphasizing the importance of a full work up to provide adequate treatment and prevent recurrence. Moreover, we show that stone disease in children, in contrast to the adult population, does not seem to be associated with obesity, as children have a weight below average at presentation.

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A Population Based Study of the Changing Demographics of Patients Undergoing Definitive Treatment for Kidney Stone Disease

Abstract: Our population based study shows an increased rate of females and of patients older than 64 years undergoing definitive treatment for kidney stones with time.

Cited by 48 publications

References 22 publications

Trends in Upper Tract Stone Disease in England: Evidence from the Hospital Episodes Statistics Database

Trends in Upper Tract Stone Disease in England: Evidence from the Hospital Episodes Statistics Database

Kidney stones

Epidemiology of paediatric renal stone disease: a 22-year single centre experience in the UK

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