A population‐based study of the outcome for patients with first relapse of Hodgkin's lymphoma

Amini, Rose‐Marie; Glimelius, Bengt; Gustavsson, Anita; Ekman, Tor; Erlanson, Martin; Haapaniemi, Eva; Enblad, Gunilla

doi:10.1034/j.1600-0609.2002.01565.x

Cited by 9 publications

(10 citation statements)

References 37 publications

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“…This is in accordance with IDHD data and results of other groups, who found no influence of time until relapse following radiotherapy [4,5,21,23].…”

Section: Discussionsupporting

confidence: 95%

“…In a study by Zijlstra et al the relation of infield to outfield relapse to both in-and outfield relapse rate was 40% to 53% to 7% (11); while in a study by Zapatero et al, where most patients had been treated with combined RT and chemotherapy, only 8% relapsed infield, 75% outfield and 17% in-and outfield [18,22]. Considerably rates of outfield relapses (72%) were also noted by a Swedish group and by an Italian group [19,23]. Prognosis does not seem to be influenced by relapse site.…”

Section: Discussionmentioning

confidence: 78%

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BEACOPP and COPP/ABVD as salvage treatment after primary extended field radiation therapy of early stage Hodgkins disease – Results of the German Hodgkin Study Group

Rüffer

Ballova

Glossmann

et al. 2005

Leukemia & Lymphoma

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Patients with early stage favorable Hodgkin's disease who relapse after extended field radiotherapy have satisfactory results. We retrospectively analysed patients with relapsed HD after initial radiation therapy alone to determine treatment outcome and prognostic factors. Nine-hundred and forty five patients in localized stages without risk factors received either 40 Gy extended field RT or 30 Gy EF RT followed by an additional 10 Gy to involved lymph node regions. 107 patients relapsed and received salvage therapy. Characteristics of the 107 patients at relapse were as follows: median age was 34 years (range 18--75) with relapse occuring at a median of 19 months (range 4--98 months), 31% were female. The majority of patients (93%) were treated with conventional chemotherapy. Sixty-nine percent were treated with COPP/ABVD like regimens, 21% with BEACOPP, and 3% received various other regimens. Seven percent were treated with radiotherapy alone. Complete remission was achieved in 87% of all salvaged patients. The median follow-up after relapse was 45 months. FF2F (freedom from second treatment failure) and OS (overall survival) were 81% and 89%, respectively. In multivariate analysis age was the major prognostic factor for FF2F and OS (p<0.0001, for both). Further independent prognostic factors were B symptoms (p=0.05) and salvage chemotherapy (p=0.03) for FF2F, and B symptoms (p=0.03) and extranodal involvement (p=0.02) for OS. The long-term outcome of patients relapsing after EF RT is excellent. Age, B symptoms, extranodal involvement and salvage chemotherapy were identified as prognostic factors for second relapse and survival.

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“…This is in accordance with IDHD data and results of other groups, who found no influence of time until relapse following radiotherapy [4,5,21,23].…”

Section: Discussionsupporting

confidence: 95%

Section: Discussionmentioning

confidence: 78%

BEACOPP and COPP/ABVD as salvage treatment after primary extended field radiation therapy of early stage Hodgkins disease – Results of the German Hodgkin Study Group

Rüffer

Ballova

Glossmann

et al. 2005

Leukemia & Lymphoma

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“…Hodgkin disease was the most common underlying disease during 1955-1979 (8.4 [1955-1966] and 6.8 [1970][1971][1972][1973][1974][1975][1976][1977][1978][1979] cases per 1000 new diagnoses, respectively), whereas no cases were observed in 1985-1997. This phenomenon may, in part, reflect the antilisteria effect of prophylactic trimethoprim-sulfamethoxazole (TMP-SMX) given to patients during high-risk periods [1,23]. A high frequency of infection (33.3 cases/1000 new admissions in [1985][1986][1987][1988][1989][1990][1991][1992][1993][1994][1995][1996][1997] in patients with myelodysplastic syndrome highlights an urgent need to evaluate antimicrobial prophylaxis in patients who are at risk.…”

Section: Discussionmentioning

confidence: 99%

Listeriosis in Patients at a Comprehensive Cancer Center, 1955-1997

Safdar¹,

Armstrong²

2003

Clinical Infectious Diseases

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Listeria monocytogenes infection occurred in 94 patients during 1955-1997 at Memorial Sloan-Kettering Cancer Center. The incidence was 0.5 (1955-1966), 0.96 (1970-1979), and 0.14 (1985-1997) cases per 1000 new admissions. Eighty-five patients (90%) were bacteremic, and 34 (36%) had evidence of intracranial infection. In 91 patients with cancer, 70 (77%) received chemotherapy for advanced or relapsed malignancy (n=51; 56%); 64 (68%) received corticosteroids. Breast cancer was the most common solid-organ cancer (n=14; 45%), and 34 (36%) had preexisting advanced liver disease. In 14 (39%) of 37 patients who died of listeriosis, death occurred within 48 h of L. monocytogenes isolation. Four (80%) of 5 patients with extracranial foci of infection died of their infection, compared with 33 (37%) of 89 patients with isolated bacteremia and/or intracranial infection (odds ratio, 2.34; P=.05). Most infections (60%) were due to L. monocytogenes serotype 1/2, and the remainder (40%) were due to serovar 4b. Listeriosis in these patients with cancer occurred most often in individuals receiving antineoplastic therapy for advanced or relapsed malignancy and systemic corticosteroids. The presence of advanced liver disease may have increased the risk of systemic listeriosis in susceptible patients with underlying cancer.

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“…15,[19][20][21]23 Other confounding factors may be the determination of EBV status by LMP-1 immunohistochemistry instead of EBER ISH. [13][14][15][16]18,19,22,[24][25][26][27]32,33 Histologic (cHL) subtype may also affect the prognostic impact of EBV status in children, adolescents, and young adults. [13][14][15][16]18,19,22,[24][25][26][27]32,33 Histologic (cHL) subtype may also affect the prognostic impact of EBV status in children, adolescents, and young adults.…”

Section: Discussionmentioning

confidence: 99%

Latent Epstein-Barr Virus Infection of Tumor Cells in Classical Hodgkin's Lymphoma Predicts Adverse Outcome in Older Adult Patients

Diepstra

Imhoff

Schaapveld

et al. 2009

JCO

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A population‐based study of the outcome for patients with first relapse of Hodgkin's lymphoma

Cited by 9 publications

References 37 publications

BEACOPP and COPP/ABVD as salvage treatment after primary extended field radiation therapy of early stage Hodgkins disease – Results of the German Hodgkin Study Group

BEACOPP and COPP/ABVD as salvage treatment after primary extended field radiation therapy of early stage Hodgkins disease – Results of the German Hodgkin Study Group

Listeriosis in Patients at a Comprehensive Cancer Center, 1955-1997

Latent Epstein-Barr Virus Infection of Tumor Cells in Classical Hodgkin's Lymphoma Predicts Adverse Outcome in Older Adult Patients

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