A Population-Based Study of Transient Ischemic Attack Incidence in Novosibirsk, Russia, 1987–1988 and 1996–1997

Abstract

Background and Purpose-Population-based data on transient ischemic attack (TIA) incidence are scarce. This study defines incidence rates of first-ever TIA in Novosibirsk, Russia, during 1987Russia, during -1997 and compares the incidence of first TIA with that of first stroke. Methods-This is a prospective registry population-based study of all new cases of TIA and stroke in an overall population of 455 765 residents of Novosibirsk. All new TIA and stroke incident cases (whether inpatient or outpatient) that occurred during 1987-1988 and 1996 -1997 study periods were recorded and analyzed. A 95% CI was estimated for all age-and sex-specific strata. Results-During the 2 study periods, a total of 211 patients with first TIA were registered in the population studied. The crude annual TIA incidence rate per 100 000 residents was 16 (95% CI, 8 to 33) in -1988 and 29 (95% CI, 9 to 87) in 1996 -1997; these rates standardized to the European population were 17 (95% CI, 8 to 34) and 27 (95% CI, 9 to 79), respectively. Eighty-three percent of TIAs occurred in the carotid arteries (rate, 48/100 000), 10% occurred in the vertebrobasilar territory (rate, 6/100 000), and 7% of cases had a TIA of uncertain distribution (rate, 2/100 000). Conclusions-Unlike stroke incidence rate, the incidence rate of TIA in Novosibirsk is similar to that in other populationsand constitutes approximately 10% of stroke incidence. For the last decade (1987)(1988)(1989)(1990)(1991)(1992)(1993)(1994)(1995)(1996)(1997), there was a tendency, although statistically insignificant, toward increasing incidence rate of TIA in the population studied. (Stroke. 2000;31:9-13.) Key Words: epidemiology Ⅲ incidence Ⅲ stroke Ⅲ transient ischemic attack P opulation-based data on transient ischemic attack (TIA) incidence are scarce. Although incidence of TIA has been reported for numerous sites worldwide, only few incident population-based studies on TIA in all age groups of the population have been reported thus far. [1][2][3][4][5][6][7][8][9][10][11] No such data in Russia have ever been published in the international literature. However, data on TIA incidence trends are important in determining mechanisms and factors responsible for the occurrence of this disorder. Thus far only 2 truly populationbased studies 2,4 have addressed a relationship between TIA and stroke incidence rates over a period of 1 or a few decades. Herein we summarize the TIA incidence rates in Novosibirsk, Russia, for the last 10 years, from 1987-1988 to 1996 -1997, and we compare the incidence of first TIA with that of first stroke obtained in the same study population and during the same study periods. Subjects and MethodsThis prospective registry population-based study was conducted during 1987-1988 and 1996 -1997 in the general, unselected, and representative districts of Novosibirsk, Oktyabrsky District and Leninsky District. The population at risk, as determined by all-union census estimates in 1989, was 155 091 residents (85 028 women and 70 063 men) in Oktyabrsky District and...

Incidence of Transient Ischemic Attack and Early Stroke Risk

“…These findings have been reported in previous studies. 18,25,26 Early stroke risk was quite similar to that previously reported. 3,4 We detected a high proportion of TIA patients who have not been admitted to hospital (50%).…”

“…In comparison with others population-based studies 11,12,18,22,[25][26][27][28] (Table 4), the incidence rate in Udine, age-adjusted to the European standard population (0.25), was very similar to that in Segovia (0.21), Dijon (0.27), and Novosibirsk (0.31). [25][26][27] Instead, the rates found in Belluno (0.58) and Rochester (0.65) were Ͼ2-times higher. 12,22 We think that our findings are plausible for the following reasons.…”

“…[23][24][25] To overcome these shortcomings, we used multiple sources of case finding (hospitals, outpatient clinics, GP, death certificates), and we provide a rigorous and standardized definition of incident TIA to include cases at an early and uniform point of the natural history of the disease. 18,26 TIA and stroke cases were assessed simultaneously to reduce the possibility of a misclassification. Standard criteria for stroke incidence study were used: prospective study design; large, well-defined, and stable population (allowing at least 100 000 person-years of observation); brain imaging in at least 80% of patients; and follow-up of patients for at least 1 month.…”

Incidence of Transient Ischemic Attack in Auckland, New Zealand, in 2011 to 2012

“…This was higher than that found in the Oxford Vascular Study (OXVASC) study, where the annual TIA incidence was 58 (95% CI, 46-69) per 100 000 people, 15 but in the middle of the range when compared with other populations studied since 2000 (Figure). [1][2][3][4]6,[16][17][18][19][20] This likely reflects higher stroke incidence in our population compared with other developed countries. 21 Ethnic differences were seen with Asian/Other having half the incidence of TIA compared with the other ethnic groups.…”

Stroke Epidemiology: Advancing Our Understanding of Disease Mechanism and Therapy

“…A study (in Rochester, Minnesota) observed a crude age-and sex-adjusted incidence rate of 68 per 100,000 persons per year for the years 1985 to 1989, the highest incidence of 584 per 100,000 noted among individuals aged 75 to 84 [8]. Other population-based TIA incidence rates range from 18 per 100,000 persons per year from 1987 to 1988 in Novosibirsk, Russia [9] to 37 per 100,000 persons per year from 1970-1973 in Estonia [10]. Data from Sweden, England, France, and Japan have also been within this range [11][12][13][14].…”