A population cohort analysis of English transplant centers indicates major adverse cardiovascular events after kidney transplantation

Anderson, Ben; Qasim, Muhammad; Evison, Felicity; Gallier, Suzy; Townend, Jonathan; Ferro, Charles J.; Sharif, Adnan

doi:10.1016/j.kint.2022.05.017

Cited by 3 publications

(2 citation statements)

References 35 publications

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“…Previous studies identified male sex as an independent variable for CV events prediction in KTRs [ 53 , 54 ]. Among 30 325 KTRs in England, men had a 20% higher risk than women for non-fatal MACE defined as any hospital admission with myocardial infarction, stroke, unstable angina, heart failure, any coronary revascularization procedure within 12 months of transplant surgery [ 55 ]. However, among 16 329 KTRs in the Australian and New Zealand registry, the standardized mortality rates were higher among transplanted women across all age groups than among men compared with the general population, despite male sex being an independent risk factor for cardiac death posttransplant [ 56 ].…”

Section: Sex Disparities In Mortality In Men and Women With Ckdmentioning

confidence: 99%

Sex disparities in mortality and cardiovascular outcomes in chronic kidney disease

Balafa,

Fernandez-Fernandez,

Ortiz

et al. 2024

Clinical Kidney Journal

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Sex (biologically determined) and gender (socially constructed) modulate manifestations and prognosis of a vast number of diseases, including cardiovascular disease (CVD) and chronic kidney disease (CKD). CVD remains the leading cause of death in CKD patients. Population-based studies indicate that women present a higher prevalence of CKD and experience less CVD than men in all CKD stages, although this is not as clear in patients on dialysis or transplantation. When compared to the general population of the same sex, CKD has a more negative impact on women on kidney replacement therapy. European women on dialysis or recipients of kidney transplants have life expectancy up to 44.8 and 19.8 years lower, respectively, than their counterparts of similar age in the general population. For men, these figures stand at 37.1 and 16.5 years, representing a 21% to 20% difference, respectively. Hormonal, genetic, societal, and cultural influences may contribute to these sex-based disparities. To gain a more comprehensive understanding of these differences and their implications for patient care, well-designed clinical trials that involve a larger representation of women and focus on sex-related variables are urgently needed. This narrative review emphasizes the importance of acknowledging the epidemiology and prognosis of sex disparities in CVD among CKD patients. Such insights can guide research into the underlying pathophysiological mechanisms, leading to optimized treatment strategies and ultimately, improved clinical outcomes.

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Section: Sex Disparities In Mortality In Men and Women With Ckdmentioning

confidence: 99%

Sex disparities in mortality and cardiovascular outcomes in chronic kidney disease

Balafa,

Fernandez-Fernandez,

Ortiz

et al. 2024

Clinical Kidney Journal

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show abstract

“…Anderson et al . [58 ▪▪ ] evaluated the rates of major adverse cardiovascular events following kidney transplantation in a contemporary cohort of 30 325 kidney transplant recipients. They found major adverse cardiovascular events in 2.6% of people within the first year of kidney transplantation; out of those, stroke accounted for 32.7% of all major adverse cardiovascular event episodes [58 ▪▪ ].…”

Section: Incidence Of Stroke Post-transplantationmentioning

confidence: 99%

Stroke and kidney transplantation

Abreo

Kataria

Amrutkar

et al. 2023

Current Opinion in Organ Transplantation

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Purpose of review This review will focus on the epidemiological data, risk factors, and management of stroke before and after kidney transplant. Stroke is highly prevalent in waitlisted patients as well as kidney transplant recipients and is associated with impaired transplant outcomes. Multiple traditional, nontraditional, and transplanted risk factors increase the risk of stroke. Recent findings Although the risk of stroke is reduced after kidney transplantation compared with remaining on dialysis, the morbidity and mortality from stroke after transplantation remain significant. Summary Early screening for risk factors before and after a kidney transplant and following the Kidney Disease Improving Global Outcomes (KDIGO) management guidelines could minimize the incidence of stroke and transplant outcomes.

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Association between sleep quality and cardiovascular disease in maintenance hemodialysis patients: a prospective cohort study

Tian,

Wang,

et al. 2023

Renal Failure

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A population cohort analysis of English transplant centers indicates major adverse cardiovascular events after kidney transplantation

Cited by 3 publications

References 35 publications

Sex disparities in mortality and cardiovascular outcomes in chronic kidney disease

Sex disparities in mortality and cardiovascular outcomes in chronic kidney disease

Stroke and kidney transplantation

Association between sleep quality and cardiovascular disease in maintenance hemodialysis patients: a prospective cohort study

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