A porcine model of systemic and renal haemodynamic responses to infrarenal aortic cross-clamping

Alric, Pierre; Ryckwaert, F.; Branchereau, Pascal; Marty-Ané, Charles-Henri; Mary, H; Colson, P

doi:10.1053/ejvs.2002.1789

Cited by 12 publications

(15 citation statements)

References 23 publications

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“…While the systemic cardiovascular consequences of infrarenal aortic cross-clamping during aortic abdominal surgery are well documented in both humans [9] and pig [19], and have been reported to be very similar (this animal model reproduces the changes observed in humans), its repercussions during laparoscopic surgery have not been reported.…”

Section: Discussionmentioning

confidence: 99%

Physiologic Responses to Infrarenal Aortic Cross-Clamping during Laparoscopic or Conventional Vascular Surgery in Experimental Animal Model: Comparative Study

Martín-Cancho

Crisóstomo

Soria

et al. 2008

Anesthesiology Research and Practice

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The aim of this study was to compare the hemodynamic and ventilatory effects of prolonged infrarenal aortic cross-clamping in pigs undergoing either laparotomy or laparoscopy. 18 pigs were used for this study. Infrarenal aortic crossclamping was performed for 60 minutes in groups I (laparotomy, n = 6) and II (laparoscopy, n = 6). Group III (laparoscopy, n = 6) underwent a 120-minute long pneumoperitoneum in absence of aortic clamping (sham group). Ventilatory and hemodynamic parameters and renal function were serially determined in all groups. A significant decrease in pH and significant increase in PaCO2 were observed in group II, whereas no changes in these parameters were seen in group I and III. All variables returned to values similar to baseline in groups I and II 60 minutes after declamping. A significant increase in renal resistive index was evidenced during laparoscopy, with significantly higher values seen in Group II. Thus a synergic effect of pneumoperitoneum and aortic cross-clamping was seen in this study. These two factors together cause decreased renal perfusion and acidosis, thus negatively affecting the patient's general state during this type of surgery.

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Section: Discussionmentioning

confidence: 99%

Physiologic Responses to Infrarenal Aortic Cross-Clamping during Laparoscopic or Conventional Vascular Surgery in Experimental Animal Model: Comparative Study

Martín-Cancho

Crisóstomo

Soria

et al. 2008

Anesthesiology Research and Practice

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“…Some experimental models induced renal ischaemia with just one suprarenal clamp [9,10], which differs from the clinical situation [11]. Infrarenal aortic-clamping alone could also lead to postoperative renal dysfunction [12][13][14][15][16]. The aim was to elucidate the role of…”

Section: Introductionmentioning

confidence: 99%

Infrarenal aortic‐clamping after renal ischaemia aggravates acute renal failure

Yeung¹,

Richir²,

Hanrath³

et al. 2010

Eur J Clin Investigation

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“…There are a number of references suggesting that swine present an excellent analog to human disease and vascular responses, especially atherosclerosis and restenosis [70][71][72][73][74]. Future investigations will include larger numbers of animals, placement in different vessels, more in-depth histological analysis, and more stent forces.…”

Section: Discussionmentioning

confidence: 99%

A link between stent radial forces and vascular wall remodeling: The discovery of an optimal stent radial force for minimal vessel restenosis

Freeman

Snowhill

Nosher

2010

Connective Tissue Research

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Coronary and peripheral artery disease (PAD) continue to be primary causes of morbidity and mortality in western nations; percutaneous transluminal angioplasty (PTA) with stenting has become a popular treatment. Unfortunately, restenosis is a significant problem following intravascular stent placement. This study considers the contribution of stent forces in vascular stenosis and remodeling to develop an equation for identifying the optimal stent force. z-Type stents of three radial forces [low (3.4 N), high (16.4 N), and ultrahigh (19.4 N)] were deployed into the iliac arteries of a juvenile porcine model. Vessel diameters were measured before, after deployment, and again at 30 days. At 30 days animals were killed and the vessels fixed in situ. After implantation, there was a significant increase in total thickness and neointimal hyperplasia with increasing stent force. The model for vessel radius and experimental data was in agreement. The model shows that maximum late-term radius is achieved with a stent deployment stress of 480 kPa, which occurs at the end of the stress-strain curve nonlinear domain and beginning of the high-strain collagen domain. The results and calculations suggest that an optimal stent force exists that is subject to the geometry, structure, and mechanics of the target vessel. To achieve maximum late-term dilatation, stents should not produce stress in the vessel wall greater than the end of the transitional domain of the vessel's stress-strain curve. This finding is extremely important for vascular stent development and will be expanded to preliminary vessel wall injury and atherosclerotic models.

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A porcine model of systemic and renal haemodynamic responses to infrarenal aortic cross-clamping

Abstract: this AXC animal model reproduces the changes observed in humans. It provides a reliable animal model which allows to investigate the underlying mechanisms of renal vasoconstriction and the effect of new drugs.

Cited by 12 publications

References 23 publications

Physiologic Responses to Infrarenal Aortic Cross-Clamping during Laparoscopic or Conventional Vascular Surgery in Experimental Animal Model: Comparative Study

Physiologic Responses to Infrarenal Aortic Cross-Clamping during Laparoscopic or Conventional Vascular Surgery in Experimental Animal Model: Comparative Study

Infrarenal aortic‐clamping after renal ischaemia aggravates acute renal failure

A link between stent radial forces and vascular wall remodeling: The discovery of an optimal stent radial force for minimal vessel restenosis

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