A Portable Albumin Binder from a DNA‐Encoded Chemical Library

Abstract

Seeing eye to eye: Plasma‐protein binding is effective in improving the pharmacokinetic properties of otherwise short‐lived molecules. One compound in a class of small portable albumin binders can be used to improve the in vivo circulatory half‐life of two widely used contrast agents. It improves the imaging performance of fluorescein in angiographic analysis of the retina of mice (see picture).

Simple bioconjugate chemistry serves great clinical advances: albumin as a versatile platform for diagnosis and precision therapy

“…13A), was contributed by the Neri group, which also targets binding site 2. 104 The dissociation constant of 428-D-Lys-β-Ala-DTPA-Gd to HSA was determined by ITC at 37 °C ( K d = 3.3 μM, Fig. 13B), while Gd-DTPA had negligible binding to HSA.…”

“…As shown, the plasma concentration time course of 177Lu-labeled MSA is listed here for comparison; (E) fluorescein angiography images in mice were recorded over 1 h after injection of 50 nmol of fluorescein (top row) and 428-D-Lys-FAM (bottom row). 104 Reprinted with permission from ref. 104.…”

“…104 Reprinted with permission from ref. 104. Copyright 2008 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.…”

“…(E) Time course of the MR signal intensity in the ROI after injection of Gd-DTPA (left panels) and 428-D-Lys-β-Ala-DTPA-Gd (right panels). 104 Reprinted with permission from ref. 104.…”

Nucleotides and Nucleic Acids; Oligo- and Polynucleotides

“…641 DNA has also been used to tag chemical libraries to allow for easy identification of reaction products (see section 3.2). [642][643][644][645] Single-walled carbon nanotubes (SWNTs) have been dissolved in aqueous solutions of dsDNA and the structures studied by AFM. The structures of these complexes were found to be different depending upon the pH of the solution, and actual structures depend on the number of holes generated in the SWNTs.…”