A portable and smartphone-operated photoelectrochemical reader for point-of-care biosensing

Catecholate Dye-Assisted Decoration of Ag on TiO2 Nanoparticles for Detection of Cancer-Related MicroRNA Biomarkers on a Multiplexed Photoelectrochemical Platform

“…Additionally, this biosensor demonstrated a high degree of specificity, showing a signal decrease of only ∼3.2% in the presence of the 100 nM nonspecific target, compared with the ∼32% signal decrease in the presence of the 100 nM specific target. Our biosensor design, based on the developed TiO 2 /HTX/Ag NP material system, can enable point-of-care detection of various biomolecules and disease biomarkers using hand-held PEC readers in the future. , …”

“…Our biosensor design, based on the developed TiO 2 /HTX/Ag NP material system, can enable point-of-care detection of various biomolecules and disease biomarkers using hand-held PEC readers in the future. 5,69 ■ ASSOCIATED CONTENT * sı Supporting Information…”

“…3−7 Photoelectrochemical (PEC) biosensors combine electrochemical signal readout with optical excitation, where the mode of signal excitation is decoupled from signal readout. 1,5,8 This decoupling allows PEC biosensors to offer high signals and low backgrounds, resulting in high sensitivity, low limit of detection (LOD), and high dynamic range. 1,7,8 Despite such high analytical performance, it remains challenging to create PEC biosensors found on stable material systems that are also easily biofunctionalized for sensing applications.…”

Recent advances on portable photoelectrochemical biosensors for diagnostics

“…The sensor is the identification layer where the fixation and biometric identification of the target takes place [79,80]. Conventional photoelectrochemical biosensors consist of three main components: excitation light sources, electrochemical workstations, and signal-receiving devices [81,82]. The source of the signal in sensing analysis is partly determined by the material with photoelectric activity [83][84][85].…”

SARS-CoV-2 detection enabled by a portable and label-free photoelectrochemical genosensor using graphitic carbon nitride and gold nanoparticles

“…The separation between excitation and signal detection can result in unique characteristics such as low background noise, low detection limit, and high sensitivity. Moreover, compared to electrochemiluminescence, PEC-based sensors are low-cost and allow miniaturization [18] using microelectronics devices, such as Arduino [19] , [20] , [21] , which can be built for current measurement and/or light source control via its components and programming script, making it a powerful tool for miniaturized PEC development.…”