A portable fluorescence resonance energy transfer biosensor for rapid detection of silver ions

Chen, Yi Ju; Liu, Cheng You; Tsai, Dong Yu; Yeh, Yi Chun

doi:10.1016/j.snb.2017.12.056

Cited by 18 publications

(8 citation statements)

References 34 publications

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“…An opposite functional scheme was described for Ag + sensing by Y.-J. Chen et al [121]. Fusing the cyan fluorescent protein (donor) and the yellow fluorescent protein through a truncated CupR protein.…”

Section: Biosensing Methodsmentioning

confidence: 99%

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Bio-Recognition in Spectroscopy-Based Biosensors for *Heavy Metals-Water and Waterborne Contamination Analysis

et al. 2019

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: Microsystems and biomolecules integration as well multiplexing determinations are key aspects of sensing devices in the field of heavy metal contamination monitoring. The present review collects the most relevant information about optical biosensors development in the last decade. Focus is put on analytical characteristics and applications that are dependent on: (i) Signal transduction method (luminescence, colorimetry, evanescent wave (EW), surface-enhanced Raman spectroscopy (SERS), Förster resonance energy transfer (FRET), surface plasmon resonance (SPR)); (ii) biorecognition molecules employed (proteins, nucleic acids, aptamers, and enzymes). The biosensing systems applied (or applicable) to water and milk samples will be considered for a comparative analysis, with an emphasis on water as the primary source of possible contamination along the food chain.

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Section: Biosensing Methodsmentioning

confidence: 99%

“…( a ) The Tl + causes the G4 structure formation, leading to a shortening of the distance between the donor and acceptor, thus inducing an enhancement in FRET efficiency [88]. ( b ) The decrease in FRET efficiency is induced by conformational change of the CupR protein, in the presence of Ag + [121]. Adapted with permission of the Publishers.…”

Section: Figurementioning

confidence: 99%

Bio-Recognition in Spectroscopy-Based Biosensors for *Heavy Metals-Water and Waterborne Contamination Analysis

et al. 2019

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“…The thiol-capping agents are grafted to the AgNPs surface through Ag-S chemical bonds to form the external layer suggesting a core@shell morphology with an Ag core surrounded by Ag 2 S-like shell. A study showed that stabilized AgNPs, by the organic thiol, allylmercaptane (AM), were synthesized with different Ag/S molar ratios in the presence of tetraoctylammonium bromide (TOAB) and NaBH 4 [119] via modified Brust−Schriffin method [121]. It has been shown that the increase in Ag/AM ratio led to an increase of the Ag 2 S layer thickness, and thus larger AgNPs were obtained, while the external AM layer remained unchanged (Figure 10A) [119].…”

Section: Organic Coatingsmentioning

confidence: 99%

Spectroscopy-Based Biosensors

2021

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“…This strategy inspired the development of different types of FRET-based biosensors around the world to examine the dynamic status of living cells and thus better understand the functional roles of molecules of interest, to precisely and rapidly predict the fate of targeted cells, and, in particular, to provide a powerful platform for drug screening [16,17]. As they require high molecular selectivity, however, GEFP biosensors to detect metal ions, such as zinc (Zn 2+ ), copper (Cu 2+ ), silver (Ag + ), cadmium (Cd 2+ ), and Pb 2+ , have been relatively difficult to generate [18][19][20][21][22][23]. Given the importance of monitoring heavy metals in environmental and biological samples, biosensors that can perform both these functions are especially desirable.…”

Section: Introductionmentioning

confidence: 99%

Versatile Cell and Animal Models for Advanced Investigation of Lead Poisoning

Yang

Chang²

2021

Biosensors

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The heavy metal, lead (Pb) can irreversibly damage the human nervous system. To help understand Pb-induced damage, we applied a genetically encoded Förster resonance energy transfer (FRET)-based Pb biosensor Met-lead 1.44 M1 to two living systems to monitor the concentration of Pb: induced pluripotent stem cell (iPSC)-derived cardiomyocytes as a semi-tissue platform and Drosophila melanogaster fruit flies as an in vivo animal model. Different FRET imaging modalities were used to obtain FRET signals, which represented the presence of Pb in the tested samples in different spatial dimensions. Using iPSC-derived cardiomyocytes, the relationship between beating activity (20–24 beats per minute, bpm) determined from the fluctuation of fluorescent signals and the concentrations of Pb represented by the FRET emission ratio values of Met-lead 1.44 M1 was revealed from simultaneous measurements. Pb (50 μM) affected the beating activity of cardiomyocytes, whereas two drugs that stop the entry of Pb differentially affected this beating activity: verapamil (2 μM) did not reverse the cessation of beating, whereas 2-APB (50 μM) partially restored this activity (16 bpm). The results clearly demonstrate the potential of this biosensor system as an anti-Pb drug screening application. In the Drosophila model, Pb was detected within the adult brain or larval central nervous system (Cha-gal4 > UAS-Met-lead 1.44 M1) using fast epifluorescence and high-resolution two-photon 3D FRET ratio image systems. The tissue-specific expression of Pb biosensors provides an excellent opportunity to explore the possible Pb-specific populations within living organisms. We believe that this integrated Pb biosensor system can be applied to the prevention of Pb poisoning and advanced research on Pb neurotoxicology.

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A portable fluorescence resonance energy transfer biosensor for rapid detection of silver ions

Cited by 18 publications

References 34 publications

Bio-Recognition in Spectroscopy-Based Biosensors for *Heavy Metals-Water and Waterborne Contamination Analysis

Bio-Recognition in Spectroscopy-Based Biosensors for *Heavy Metals-Water and Waterborne Contamination Analysis

Spectroscopy-Based Biosensors

Versatile Cell and Animal Models for Advanced Investigation of Lead Poisoning

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