Design of Mobile Patient Monitoring Frameworks (MPMF) is an emerging study in the biomedical informatics domain. However, literature about this topic remains fragmented: first, there are no categories in the literature to characterize these MPMF; second, there are no success factors that must be satisfied to enhance the design of these MPMF; third, there is a need for a research agenda that provides a foundation for further research and development to enhance the design of these MPMF. To address this gap, this paper reviews software frameworks in general and conducts a systematic review of 20 designed frameworks in the biomedical informatics domain. Consequently, this paper provides three results. First, it identifies a number of categories to be used to gain an intensive and extensive understanding of the designed MPMF. Second, it identifies a set of success factors, called Factors of Successful Application Frameworks (FSAF), to be used to enhance the design of MPMF. Third, it presents a research agenda that shows lacks and gaps in the designed MPMF and provides a foundation to help researchers design enhanced MPMF. The results show that, as of yet, there is no study integrating all the FSAF to enhance the design of MPMF. Therefore, there is a need for further research to enhance the existing MPMF design.