A portable high-intensity focused ultrasound device for noninvasive venous ablation

Henderson, Peter W.; Lewis, George K.; Shaikh, Naima; Sohn, Allie M.; Weinstein, Andrew L.; Olbricht, William L.; Spector, Jason A.

doi:10.1016/j.jvs.2009.10.049

Cited by 26 publications

(22 citation statements)

References 19 publications

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“…Collagen undergoes isovolumetric shrinkage of up to 60% of its length when heated above this threshold, the majority of which occurs within 1 s [51]. Such vessel shrinkage has been demonstrated ex vivo where the luminal cross-sectional area of a non-perfused vessel was reduced by up to 96% [32,52], although this effect is much less pronounced in perfused vessels in vivo [38]. Heating of collagen beyond this threshold leads to hyalinization and fracturing of its structure, which contributes to tissue stiffness, and is a possible explanation for why vessels subjected to multiple HIFU exposures stiffen and become prone to rupture [18].…”

Section: Effect Of Heating On Vessels and Highintensity Focused Ultramentioning

confidence: 98%

“…Inertial cavitation induced damage produces a comparable activation of the acute inflammatory response, though this response does not convert into a chronic inflammatory response in the absence of tissue damage [7]. Extracellular oedema is known to reduce blood flow, especially in smaller vessels, and perivascular oedema resulting from HIFU exposure has been cited as contributing to lumenal constriction [32]. The role of the inflammatory response in controlling and organizing the physiological response to vascular damage cannot be discounted.…”

Section: Contribution Of the Inflammatory Response And Repair Mechanismsmentioning

confidence: 99%

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Pathophysiological mechanisms of high-intensity focused ultrasound-mediated vascular occlusion and relevance to non-invasive fetal surgery

Shaw

Haar

Rivens

et al. 2014

J. R. Soc. Interface.

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ReviewCite this article: Shaw CJ, ter Haar GR, Rivens IH, Giussani DA, Lees CC. 2014 Pathophysiological mechanisms of high-intensity focused ultrasound-mediated vascular occlusion and relevance to non-invasive fetal surgery. J. R. Soc. High-intensity focused ultrasound (HIFU) is a non-invasive technology, which can be used occlude blood vessels in the body. Both the theory underlying and practical process of blood vessel occlusion are still under development and relatively sparse in vivo experimental and therapeutic data exist. HIFU would however provide an alternative to surgery, particularly in circumstances where serious complications inherent to surgery outweigh the potential benefits. Accordingly, the HIFU technique would be of particular utility for fetal and placental interventions, where open or endoscopic surgery is fraught with difficulty and likelihood of complications including premature delivery. This assumes that HIFU could be shown to safely and effectively occlude blood vessels in utero. To understand these mechanisms more fully, we present a review of relevant cross-specialty literature on the topic of vascular HIFU and suggest an integrative mechanism taking into account clinical, physical and engineering considerations through which HIFU may produce vascular occlusion. This model may aid in the design of HIFU protocols to further develop this area, and might be adapted to provide a non-invasive therapy for conditions in fetal medicine where vascular occlusion is beneficial.

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Section: Effect Of Heating On Vessels and Highintensity Focused Ultramentioning

confidence: 98%

Section: Contribution Of the Inflammatory Response And Repair Mechanismsmentioning

confidence: 99%

Pathophysiological mechanisms of high-intensity focused ultrasound-mediated vascular occlusion and relevance to non-invasive fetal surgery

Shaw

Haar

Rivens

et al. 2014

J. R. Soc. Interface.

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“…42 Portable high-intensity FUS devices were tested for several other applications in other tissues, including non-invasive venous ablation, 43 reduction of subcutaneous adipose tissue and non-invasive body sculpting. 44 (c) An analysis of factors affecting clinical success of MRgFUS should be performed.…”

Section: Mrgfus Lessons Learned From Non-musculoskeletal Applicationsmentioning

confidence: 99%

MRI-guided focused ultrasound surgery in musculoskeletal diseases: the hot topics

Bazzocchi¹,

Napoli²,

Sacconi³

et al. 2016

BJR

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MRI-guided focused ultrasound surgery (MRgFUS) is a minimally invasive treatment guided by the most sophisticated imaging tool available in today's clinical practice. Both the imaging and therapeutic sides of the equipment are based on non-ionizing energy. This technique is a very promising option as potential treatment for several pathologies, including musculoskeletal (MSK) disorders. Apart from clinical applications, MRgFUS technology is the result of long, heavy and cumulative efforts exploring the effects of ultrasound on biological tissues and function, the generation of focused ultrasound and treatment monitoring by MRI. The aim of this article is to give an updated overview on a "new" interventional technique and on its applications for MSK and allied sciences

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“…The concept is to generate an output signal that can follow the input signal in phase and frequency, while having a higher power level. Non-linear PAs were found attractive for HIFU systems due to their high efficiencies [16,22,21,30,31]. Mainly, PA classes D and E can be used for HIFU.…”

Section: Output Stage and Power Amplifiersmentioning

confidence: 99%

Driving Circuitry for Focused Ultrasound Noninvasive Surgery and Drug Delivery Applications

El‐Desouki

Hynynen

2011

Sensors

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Recent works on focused ultrasound (FUS) have shown great promise for cancer therapy. Researchers are continuously trying to improve system performance, which is resulting in an increased complexity that is more apparent when using multi-element phased array systems. This has led to significant efforts to reduce system size and cost by relying on system integration. Although ideas from other fields such as microwave antenna phased arrays can be adopted in FUS, the application requirements differ significantly since the frequency range used in FUS is much lower. In this paper, we review recent efforts to design efficient power monitoring, phase shifting and output driving techniques used specifically for high intensity focused ultrasound (HIFU).

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A portable high-intensity focused ultrasound device for noninvasive venous ablation

Cited by 26 publications

References 19 publications

Pathophysiological mechanisms of high-intensity focused ultrasound-mediated vascular occlusion and relevance to non-invasive fetal surgery

Pathophysiological mechanisms of high-intensity focused ultrasound-mediated vascular occlusion and relevance to non-invasive fetal surgery

MRI-guided focused ultrasound surgery in musculoskeletal diseases: the hot topics

Driving Circuitry for Focused Ultrasound Noninvasive Surgery and Drug Delivery Applications

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