A portable pressure pump for microfluidic lab-on-a-chip systems using a porous polydimethylsiloxane (PDMS) sponge

Je, Kyoung; Kim, Dong Sung

doi:10.1007/s10544-011-9557-z

Cited by 50 publications

(37 citation statements)

References 25 publications

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“…Another study utilized PDMS sponge for a portable pressure pump for microfluidic lab-on-a-chip systems. 10 The volume capacity of the sponge enables it to uptake, store, and release the fluid of interest through strain control.…”

mentioning

confidence: 99%

Flexible, compressible, hydrophobic, floatable, and conductive carbon nanotube-polymer sponge

Han

Kim

et al. 2013

Applied Physics Letters

121

104

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A flexible, compressible, hydrophobic, ice-repelling, floatable, and conductive carbon nanotube (CNT)-polydimethylsiloxane (PDMS) sponge is presented. The microporous sponge-like PDMS scaffold fabricated with a sugar cube template is capable of CNT uptake. The CNT-PDMS sponge (CPS) is deformable and compressible up to 90%. The Young's modulus varies from 22 KPa to 200 KPa depending on the applied strain. The conductive pathways via the CNT network increase with compressive strain similar to a variable resistor or pressure sensor. The softness of the CPS can be utilized for artificial skin to grip sensitive objects. In addition, the contact angle of water droplets on CPS shows 141°, and thus the hydrophobic nature of the CPS can be exploited as a floating electrode. Furthermore, the hydrophobicity is maintained below freezing temperature, allowing an ice-repelling electrode.

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mentioning

confidence: 99%

Flexible, compressible, hydrophobic, floatable, and conductive carbon nanotube-polymer sponge

Han

Kim

et al. 2013

Applied Physics Letters

121

104

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“…The fabrication method of the porous PDMS scaffold was based on a sugar leaching technique . In this study, two sugar cubes of 1.5×1.5×1 cm 3 were first stacked upon one another in a Petri dish filled with pre‐cured PDMS.…”

Section: Methodsmentioning

confidence: 99%

Perfusion enhanced polydimethylsiloxane based scaffold cell culturing system for multi‐well drug screening platform

Tania

Hsu

Png

et al. 2014

Biotechnology Progress

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Conventional two-dimensional cultures in monolayer and sandwich configuration have been used as a model for in vitro drug testing. However, these culture configurations do not present the actual in vivo liver cytoarchitecture for the hepatocytes cultures and thus they may compromise the cells liver-specific functions and their cuboidal morphology over longer term culture. In this study, we present a three-dimensional polydimethylsiloxane (PDMS) scaffold with interconnected spherical macropores for the culturing of rat liver cells (hepatocytes). The scaffolds were integrated into our perfusion enhanced bioreactor to improve the nutrients and gas supply for cell cultures. The liver-specific functions of the cell culture were assessed by their albumin and urea production, and the changes in the cell morphology were tracked by immunofluorescence staining over 9 days of culture period. N-Acetyl-Para-Amino-Phenol (acetaminophen) was used as drug model to investigate the response of cells to drug in our scaffold-bioreactor system. Our experimental results revealed that the perfusion enhanced PDMS-based scaffold system provides a more conducive microenvironment with better cell-to-cell contacts among the hepatocytes that maintains the culture specific enzymatic functions and their cuboidal morphology during the culturing period. The numerical simulation results further showed improved oxygen distribution within the culturing chamber with the scaffold providing an additional function of shielding the cell cultures from the potentially detrimental fluid induced shear stresses. In conclusion, this study could serve a crucial role as a platform for future preclinical hepatotoxicity testing.

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“…Gaur egun kontrol mikro-fluidikorako osagai ugari aurki ditzakegu, eta horien artean mikro-balbulak eta mikro-ponpak dira garrantzitsuenak. Analisirako sistema autonomoak egiteko orduan osagai autopropultsatuak erabiltzea interesgarria denez, azken urteetan mota horretako osagaien sorta zabala aurki daiteke [6][7][8]. Orain arte fabrikazio teknika eta material ezberdinak erabili izan dira halako osagaiak garatzeko.…”

Section: Arloko Egoera Eta Ikerketaren Helburuakunclassified

Diagnosi azkarrera bideratutako gailu mikro-fluidikoen garapen eta azterketa

Etxebarria-Elezgarai¹,

Romero²,

Lawrie³

et al. 2018

EKAIA

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Laburpena: Lan honetan minbiziaren diagnosi goiztiarrerako eta tratamenduen egokitzapenerako kontzeptu berri bat aurkezten da, non gailu hibrido miniaturizatu batekin odoleko DNA zirkulatzailea analizatuz, kasuan kasuko mutazioaren presentziarik ote dagoen ezagutu nahi den. Egitura hibridodun gailua paperezko zein material polimerikozko mikro-egituraz osatuta egongo da, eta laginaren prestakuntzarako, seinalearen anplifikaziorako eta detekziorako modulu ezberdinak izango ditu. Halaber, analisiak in situ egin eta emaitzak denbora gutxian eskuratzeko aukera emango digu, kostu gutxiko analisiekin pazientearen jarraipen egokituago bat egin ahal izateko.Hitz gakoak: mikro-teknologiak, diagnostiko azkarra, in situ analisia, txip mikro-fluidiko hibridoak.Abstract: This work presents a new concept of a hybrid Point-of-Care (POC) device developed for the detection of cancer biomarkers in blood, circulating DNA, for early cancer diagnostics. The device is composed of both, paper and polymeric based selfpowered microfluidic structures and it includes several modules with different func-

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A portable pressure pump for microfluidic lab-on-a-chip systems using a porous polydimethylsiloxane (PDMS) sponge

Cited by 50 publications

References 25 publications

Flexible, compressible, hydrophobic, floatable, and conductive carbon nanotube-polymer sponge

Flexible, compressible, hydrophobic, floatable, and conductive carbon nanotube-polymer sponge

Perfusion enhanced polydimethylsiloxane based scaffold cell culturing system for multi‐well drug screening platform

Diagnosi azkarrera bideratutako gailu mikro-fluidikoen garapen eta azterketa

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