A portable surface plasmon resonance (SPR) sensor system with temperature regulation

Naimushin, Alexei N.; Soelberg, Scott D.; Bartholomew, D. U.; Elkind, J. L.; Furlong, Clement E.

doi:10.1016/s0925-4005(03)00533-1

Cited by 121 publications

(55 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Signal amplification using particle tags [1][2][3][4] can be an effective method of enhancing the surface plasmon resonance (SPR)-based detection of low molecular weight or low concentration analytes at planar gold surfaces. For SPR-based detection, the particle tag will ideally be composed of a material that produces a large change in refractive index (RI) per unit volume of tag material.…”

Section: Introductionmentioning

confidence: 99%

Dependence of the signal amplification potential of colloidal gold nanoparticles on resonance wavelength in surface plasmon resonance-based detection

Ramsey²,

Yager³

2007

Analytica Chimica Acta

View full text Add to dashboard Cite

We demonstrate the resonance wavelength-dependent signal of colloidal gold nanoparticles adsorbed to a planar gold surface in surface plasmon resonance (SPR)-based detection. Experimental measurements of the SPR signal as a function of particle surface coverage are presented for three different resonance wavelengths. The SPR signal due to the colloidal gold nanoparticles varies across the resonance wavelengths of 650 nm, 770 nm, and 920 nm. The experimental SPR curves show good agreement with the results of a Lorentz absorbance model at the lower particle surface coverages investigated. The results demonstrate an almost 2-fold signal difference for a subset of the experimental conditions explored.

show abstract

Section: Introductionmentioning

confidence: 99%

Dependence of the signal amplification potential of colloidal gold nanoparticles on resonance wavelength in surface plasmon resonance-based detection

Ramsey²,

Yager³

2007

Analytica Chimica Acta

View full text Add to dashboard Cite

show abstract

“…Companies such as Texas Instrument (Spreeta) [4,5], K-MAC (Biochip Analyzer, SPRmicro), Seattle Sensor Systems (SPIRIT) [6], and Möbius advanced technology (handheld SPR) currently market portable instruments. The RI resolution of portable instruments is of the order of~2×10 −6 refractive index units (RIU), in comparison with~2×10 −7 RIU [6][7][8] for a high-performance laboratory SPR instrument.…”

mentioning

confidence: 99%

“…1B), for example singlestrand DNA, antibody, protein. Proteins indicative of diseases (prostate-specific antigen and troponin I) [12,13] and biological warfare agents (Staphylococcus aureus enterotoxin) [4,14] have been detected with small and portable SPR instruments. Low nanomolar or high picomolar detection limits have been reported for most of these small molecules or biomolecules (Fig.…”

mentioning

confidence: 99%

Nanostructured substrates for portable and miniature SPR biosensors

Breault-Turcot

Masson

2012

Anal Bioanal Chem

View full text Add to dashboard Cite

Surface plasmon resonance (SPR) biosensing has matured into a valuable analytical technique for measurements related to biomolecules, environmental contaminants, and the food industry. Contemporary SPR instruments are mainly suitable for laboratory-based measurements. However, several point-of-measurement applications would benefit from simple, small, portable and inexpensive sensors to assess the health condition of a patient, potential environmental contamination, or food safety issues. This Trend article explores nanostructured substrates for improving the sensitivity of classical SPR instruments and nanoparticle (NP)-based colorimetric substrates that may provide a solution to the development of point-of-measurement SPR techniques. Novel nanomaterials and methodology capable of enhancing the sensitivity of classical SPR sensors are destined to improve the limits of detection of miniature SPR instruments to the level required for most applications. In a different approach, paper or substrate-based SPR assays based on NPs, are a highly promising topic of research that may facilitate the widespread use of a novel class of miniature and portable SPR instruments.

show abstract

“…A detailed description of potential optimization steps was discussed in Chapter 4 (Chapter 4.5.5). Briefly, all future work should be performed in a temperature control setting (Dudak & Boyaci, 2009;Dutra et al, 2007;He et al, 2007;Matsumoto et al, 2005;Naimushin et al, 2003). Flow rates of both the reference buffer and the injections should be determined so that enough time is allowed for molecules to interact on the gold surface without causing unbound molecule aggregates to form on the surface (Dudak & Boyaci, 2009;Skottrup et al, 2008).…”

Section: This Research Study Developed Spr Immunosensors To Detect Stmentioning

confidence: 99%

“…Lack of temperature control causes an increase in standard deviation between readings (Dutra et al, 2007;He et al, 2007;Matsumoto et al, 2005;Naimushin et al, 2003). Additionally, the instrument uses microfluidics to transfer chemicals to the gold sensor chip (Biosensing Instrument, 2006).…”

mentioning

confidence: 99%

A Multi-Faceted Diagnostic Approach to Lung Infections in Patients with Cystic Fibrosis

Doud¹

View full text Add to dashboard Cite

A portable surface plasmon resonance (SPR) sensor system with temperature regulation

Cited by 121 publications

References 15 publications

Dependence of the signal amplification potential of colloidal gold nanoparticles on resonance wavelength in surface plasmon resonance-based detection

Dependence of the signal amplification potential of colloidal gold nanoparticles on resonance wavelength in surface plasmon resonance-based detection

Nanostructured substrates for portable and miniature SPR biosensors

A Multi-Faceted Diagnostic Approach to Lung Infections in Patients with Cystic Fibrosis

Contact Info

Product

Resources

About