A positive correlation between sickle cell anemia and g6pd deficiency from population of Chhattisgarh, India

Shivwanshi, Lohit Raj; Singh, Ekta; Kumar, Anil

doi:10.1016/j.gene.2019.04.080

Cited by 6 publications

(2 citation statements)

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“…A positive correlation was observed between G6PD deficient and sickle cell anemia in a study conducted in India, and numerous diseases and sicknesses have been recognized because of the oxidative stress condition (SHIVWANSHI et al, 2019). The blood donors of Cameroonian showed 7.9% prevalence of G6PD deficiency in males and a positive significant higher frequency of hepatitis C virus and rapid plasma reagin when compared with that of normal donors (LAUDEN et al, 2019).…”

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confidence: 92%

Recent trends of glucose-6-phosphate dehydrogenase deficiency among saudi population in Riyadh city

Qahtany

2019

Biosci. J.

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G6PD deficiency is associated with erythrocyte deficiency in the X-chromosome enzyme. It causes a hematologic syndrome called hemolytic anemia that connects G6PD deficiency with X-linked condition. In the Middle East, including Saudi Arabia, G6PD deficiency is the most dominant genetic blood disorders. It results in higher rates of mortality and morbidity due to its incurable long-lasting nature and prevalence of physical and psychological incapacities. In this study, an attempt was made to evaluate the prevalence of G6PD deficiency among the Saudi population in Riyadh city. A cross-sectional retrospective study was conducted at King Saud University Medical City in Riyadh, Saudi Arabia. The population of the study comprised randomly chosen males and females who visited the hospital from January 2017 to January 2018. Statistical analyses were performed using SPSS, and descriptive analysis was used to find the frequency of G6PD-deficient patients. Out of the 209 patients, 62.2% were males (n=130) and 37.8% were females (n=79). Twenty males and 6 females were found to have G6PD deficiency, with the male to female ratio being 1:3. Out of the total 130 male participants, 20 patients were found to be enzyme deficient and 6 patients of 79 female patients were found to be G6PD deficient. There were 38.4% (n=10) patients with G6PD level <4 units/gram hemoglobin, 26.9% (n=7) patients had G6PD levels of 4.1–7.0 units/gram hemoglobin, and 34.6% (n=9) patients had >7 units/gram hemoglobin. Among the G6PD patients, 23.07% patients were severely anemic, and 5 (19.2%) patients were reported to have high bilirubin. The present study revealed the G6PD prevalence to be 12.4% among the Saudi population; this value is significantly higher than that found in France, Spain, India, and Singapore. In the Saudi population, males are more vulnerable to G6PD-deficient than females. Hence, attention should be paid to G6PD-deficient patients while prescribing antimalarial medication. Such patients may be advised to avoid certain foods to minimize the risk of having hemolytic episodes.

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Section: Contentsmentioning

confidence: 92%

Recent trends of glucose-6-phosphate dehydrogenase deficiency among saudi population in Riyadh city

Qahtany

2019

Biosci. J.

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“…Despite being carried on different chromosomes, these abnormalities can coexist in the same individual, potentially leading to increased hemolysis [2]. The impact of G6PD deficiency on sickle cell disease, as well as the disease's epidemiological, clinical, and evolutionary profiles, has been extensively studied and debated [3] [4] [5]. It is evident, however, that recognizing this association is vital for preventing hemolytic episodes in sickle cell patients, as it guides the avoidance of oxidizing drugs and foods.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Association of Glucose-6-Phosphate Dehydrogenase Deficiency and Sickle Cell Disease at the National Teaching Hospital of Cotonou in Benin

Zohoun,

Baglo-Agbodande,

Adje

et al. 2023

OJBD

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Background: Glucose-6-phosphate dehydrogenase (G6PD) deficiency and sickle cell disease are common genetic defects of red blood cells that lead to hemolytic anemia. The prevalence of G6PD deficiency in sickle cell patients is unknown in Benin. Objective: This study aimed to determine the prevalence of G6PD deficiency in sickle cell patients at the CNHU-HKM of Cotonou. Methods: This prospective study was conducted from April to November 2022 at the blood-related diseases teaching clinic and included sickle cell patients in the stationary phase. G6PD determination was performed using the enzymatic method on a Mindray BS 200 machine following the Herz method. Hematological parameters were determined using the XT 4000i analyzer and supplemented by a blood smear stained with May Grunwald Giemsa. Data were analyzed using Epi Info 3.5.4 software. Results: One hundred and sixty-four sickle cell patients (80 SS homozygotes and 84 SC heterozygotes) in the intercritical phase, with a mean age of 26.30 ± 10.76 years, were included. The prevalence of G6PD deficiency was 9.1% (15 cases found in 7 SS patients and 8 SC patients). In G6PD-deficient patients, the mean concentration of the enzyme was lower in Hb SC heterozygotes than in Hb SS homozygotes: 3.56 IU/g Hb versus 4.98 IU/g Hb. The mean reticulocyte count was 231.43 G/L in the deficient group, compared to 216.32 G/L in the non-deficient group. Conclusion: The preliminary results of our study reveal a high prevalence of G6PD deficiency in sickle cell patients. The impact of this association on he-

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Prevalence and spectrum of mutations causing G6PD deficiency in Indian populations

Devendra

Gupta

Shanmugam

et al. 2020

Infection, Genetics and Evolution

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A positive correlation between sickle cell anemia and g6pd deficiency from population of Chhattisgarh, India

Cited by 6 publications

References 28 publications

Recent trends of glucose-6-phosphate dehydrogenase deficiency among saudi population in Riyadh city

Recent trends of glucose-6-phosphate dehydrogenase deficiency among saudi population in Riyadh city

Prevalence of Association of Glucose-6-Phosphate Dehydrogenase Deficiency and Sickle Cell Disease at the National Teaching Hospital of Cotonou in Benin

Prevalence and spectrum of mutations causing G6PD deficiency in Indian populations

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