A positive relationship between harm avoidance and brain nicotinic acetylcholine receptor availability

Storage, Steven; Mandelkern, M.; Phuong, Jonathan; Kozman, Maggie; Neary, Meaghan K.; Brody, Arthur L.

doi:10.1016/j.pscychresns.2013.07.010

Cited by 9 publications

(6 citation statements)

References 85 publications

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“…Although nicotine gets into the body through various means—such as chewing of tobacco leaves and absorption of nicotine through the skin [ 12 , 13 ]—the most predominant route of nicotine use is through tobacco smoke in cigarettes and pipes (respiratory) [ 14 , 15 ]. Interestingly, several studies have reported the presence of cadmium, carbon monoxide, lead, cooper, silicon, and alkaloids in the tobacco smoke [ 14 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

Nicotine-Cadmium Interaction Alters Exploratory Motor Function and Increased Anxiety in Adult Male Mice

Ajonijebu

Adeniyi

Adekeye

et al. 2014

Journal of Neurodegenerative Diseases

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In this study we evaluated the time dependence in cadmium-nicotine interaction and its effect on motor function, anxiety linked behavioural changes, serum electrolytes, and weight after acute and chronic treatment in adult male mice. Animals were separated randomly into four groups of n = 6 animals each. Treatment was done with nicotine, cadmium, or nicotine-cadmium for 21 days. A fourth group received normal saline for the same duration (control). Average weight was determined at 7-day interval for the acute (D1-D7) and chronic (D7-D21) treatment phases. Similarly, the behavioural tests for exploratory motor function (open field test) and anxiety were evaluated. Serum electrolytes were measured after the chronic phase. Nicotine, cadmium, and nicotine-cadmium treatments caused no significant change in body weight after the acute phase while cadmium-nicotine and cadmium caused a decline in weight after the chronic phase. This suggests the role of cadmium in the weight loss observed in tobacco smoke users. Both nicotine and cadmium raised serum Ca2+ concentration and had no significant effect on K+ ion when compared with the control. In addition, nicotine-cadmium treatment increased bioaccumulation of Cd2+ in the serum which corresponded to a decrease in body weight, motor function, and an increase in anxiety.

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Section: Introductionmentioning

confidence: 99%

Nicotine-Cadmium Interaction Alters Exploratory Motor Function and Increased Anxiety in Adult Male Mice

Ajonijebu

Adeniyi

Adekeye

et al. 2014

Journal of Neurodegenerative Diseases

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“…Recent studies pointed that acetylcholine plays a important role in the behaviors related to fear and anxiety, through the action on nicotinic or muscarinic receptors (Kenney et al, 2012; Kutlu and Gould, 2015; Pidoplichko et al, 2019; Santini et al, 2012). Importantly, brain areas, such as hippocampus and amygdala, involved in anxious features receive a dense cholinergic impulse (Pidoplichko et al, 2019; Santini et al, 2012; Storage et al, 2013). In this study, we investigated the effects of leucine exposure in young zebrafish on the brain activity of important enzymes of cholinergic system.…”

Section: Discussionmentioning

confidence: 99%

Acute exposure to leucine modifies behavioral parameters and cholinergic activity in zebrafish

Wessler

Farias

Ronsani

et al. 2019

Intl J of Devlp Neuroscience

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Maple Syrup Urine Disease (MSUD) is an autosomal recessive inherited disorder, caused by a deficiency on branched chain α-ketoacid dehydrogenase complex activity, resulting in accumulation of branched-chain amino acids (BCAA) (e.g. leucine). The treatment of MSDU patients increases survival time and quality of life. Thus, nowadays there are a crescent number of adolescents and adults with MSUD. Relevant studies have been reported behavioral alterations in these patients, i.e. high risk of chronic neuropsychiatric problems, such as attention deficit disorder, depression and anxiety. Moreover, MSUD is associated to neurotransmitters deficiency. Herein, we aimed to investigate whether the toxicity of leucine is associated to anxiety-like behavioral, using zebrafish acutely exposed to leucine as experimental model of MSUD. In addition, we evaluated the effects of high levels of leucine in the acetylcholinesterase (AChE) and choline acetyltransferase (ChAT) activities, components of cholinergic neurotransmission system. Young zebrafish were exposed to 2 mM and 5 mM concentration of leucine for 24 h. After that, the animals were submitted to the Novel Tank test, having the brain collected to enzymatic determination. The exposure to both concentrations of leucine caused behavioral and brain cholinergic activity alterations in young zebrafish, indicating an anxiety-like behavior and cholinergic dysfunction. Therefore, this animal could be considered a promising organism to study the BCAA neurotoxic effects, which could help to a better comprehension of the behavioral and neurochemical alterations present in patients with MSUD.

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“…[ 48 ] Anxiety may be associated with irregular growth hormone and melatonin rhythms which can be altered by basic lifestyle habits. [ 49 ] Minor events of daily life associates with adrenocortocal activity. [ 50 ] Baseline psychological deviations between groups are because of the surgical trauma, and it can influence the outcomes of phase-2 rehabilitation.…”

Section: Discussionmentioning

confidence: 99%

Yoga-Based Postoperative Cardiac Rehabilitation Program for Improving Quality of Life and Stress Levels

Eraballi

Ramarao

Nagarathna

et al. 2018

International Journal of Yoga

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Objectives: This study was aimed to assess the efficacy of yoga-based lifestyle program (YLSP) in improving quality of life (QOL) and stress levels in patients after 5 years of coronary artery bypass graft (CABG). Methodology: Three hundred patients posted for elective CABG in Narayana Hrudayalaya Super Speciality Hospital, Bengaluru, were randomized into two groups: YLSP and conventional lifestyle program (CLSP), and follow-up was done for 5 years. Intervention: In YLSP group, all practices of integrative approach of yoga therapy such as yama, niyama, asana, pranayama, and meditation were used as an add-on to conventional cardiac rehabilitation. The control group (CLSP) continued conventional cardiac rehabilitation only. Outcome Measures: World Health Organization (WHO)-QOL BREF Questionnaire, Perceived Stress Scale, Positive and Negative Affect Scale (PANAS), and Hospital Anxiety and Depression Scale (HADS) were assessed before surgery and at the end of the 5th year after CABG. As data were not normally distributed, Mann–Whitney U-test was used for between-group comparisons and Wilcoxon's signed-rank test was used for within-group comparisons. Results: At the end of 5 years, mental health (P = 0.05), perceived stress (P = 0.01), and negative affect (NA) (P = 0.05) have shown significant improvements. WHO-QOL BREF score has shown improvements in physical health (P = 0.046), environmental health (P = 0.04), perceived stress (P = 0.001), and NA (P = 0.02) in YLSP than CLSP. Positive affect has significantly improved in CLSP than YLSP. Other domains of WHO-QOL-BREF, PANAS, and HADS did not reveal any significant between-group differences. Conclusion: Addition of long-term YLSP to conventional cardiac rehabilitation brings better improvements in QOL and reduction in stress levels at the end of 5 years after CABG.

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A positive relationship between harm avoidance and brain nicotinic acetylcholine receptor availability

Cited by 9 publications

References 85 publications

Nicotine-Cadmium Interaction Alters Exploratory Motor Function and Increased Anxiety in Adult Male Mice

Nicotine-Cadmium Interaction Alters Exploratory Motor Function and Increased Anxiety in Adult Male Mice

Acute exposure to leucine modifies behavioral parameters and cholinergic activity in zebrafish

Yoga-Based Postoperative Cardiac Rehabilitation Program for Improving Quality of Life and Stress Levels

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