A positive umbilical venous-arterial difference of leptin level and its rapid decline after birth

Yura, Shigeo; Sagawa, Norimasa; Mise, Hiroko; Mori, Takahide; Masuzaki, Hiroaki; Ogawa, Yoshihiro; Nakao, Kazuwa

doi:10.1016/s0002-9378(98)70525-3

Cited by 95 publications

(53 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In a study by Hassink et al (19), leptin concentrations in the cord blood were independent of insulin and glucose levels, and leptin mRNA expression in the placental tissue has been demonstrated. Furthermore, in a study by Yura et al (25) higher leptin levels in the umbilical veins than in umbilical arteries were found, which is consistent with leptin secretion from placenta to the fetal circulation. This notion is further supported by a significant positive correlation of cord leptin levels and placental weight in our as well as other studies (12,24).…”

Section: Discussionsupporting

confidence: 66%

Leptin levels at birth and in early postnatal life in small- and appropriate-for-gestational-age infants

Valūnienė¹,

Verkauskienė²,

Boguszewski

et al. 2007

Medicina

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 66%

Leptin levels at birth and in early postnatal life in small- and appropriate-for-gestational-age infants

Valūnienė¹,

Verkauskienė²,

Boguszewski

et al. 2007

Medicina

View full text Add to dashboard Cite

show abstract

“…18,19 This leptin may affect fetal growth by altering metabolism in the dam. In addition, some placental leptin may reach the fetal circulation 18,20 and influence fetal growth more directly. Thus, umbilical cord blood leptin levels and placental leptin mRNA correlate with various indices of size at birth.…”

Section: Introductionmentioning

confidence: 99%

Modulation of susceptibility to weight gain and insulin resistance in low birthweight rats by treatment of their mothers with leptin during pregnancy and lactation

et al. 2003

View full text Add to dashboard Cite

OBJECTIVES:To investigate whether administration of leptin to rats during pregnancy and lactation affects placental 11b-hydroxysteroid dehydrogenase (11b-HSD2) activity and the susceptibility of their offspring to weight gain and insulin resistance. DESIGN: Pregnant rats fed on a low-protein diet were administered leptin or saline by subcutaneous minipump from day 14 of gestation and throughout lactation. A further group was fed a normal diet and given saline. After weaning, the offspring of each group were fed on a normal diet until 6 weeks of age and then half of each group was transferred to a high-fat diet until 12 months of age. RESULTS: Plasma leptin levels were raised two-fold on days 16-18 of pregnancy in the leptin-treated dams, but, despite a constant rate of infusion, at parturition they dipped to control levels before rising again. The activity of placental 11b-HSD2 was reduced by the low-protein diet; this reduction was prevented by treating the dams with leptin. The male offspring of the salinetreated dams gained more weight and had higher plasma leptin levels on the high fat than the chow diet, but the offspring of the leptin-treated dams did not. Fasting blood glucose and intraperitoneal glucose tolerance at 6 and 12 months of age was unaffected by the high-fat diet, but only the offspring of the leptin-treated dams achieved this control without raised insulin levels. CONCLUSIONS: The rate of leptin clearance appears to increase at parturition. The administration of leptin to rats during late pregnancy and lactation makes their male offspring less susceptible to high-fat-diet-induced weight gain and insulin resistance.

show abstract

“…We previously reported that leptin is also produced by placental trophoblasts and secreted into both maternal and fetal circulations, leading to increased maternal plasma leptin concentrations during pregnancy [8,9]. Linnemann et al reported that 98.4% of placental leptin is secreted into maternal circulation and 1.6% into the fetal circulation [10].…”

mentioning

confidence: 99%

Free-to-Total Leptin Ratio in Maternal Plasma is Constant Throughout Human Pregnancy

et al. 2003

Self Cite

View full text Add to dashboard Cite

Abstract. To clarify the mechanism of leptin resistance during pregnancy, we measured plasma leptin concentrations, free to total leptin ratio (percent free leptin) and soluble leptin receptor concentrations in pregnant women, and compared the results with those in non-pregnant women. We collected plasma samples from 23 non-pregnant and 31 pregnant women in the third trimester. Plasma samples from 5 pregnant women were collected longitudinally in each trimester. Plasma leptin concentrations in pregnant women in the second trimester (17.4 ± 3.2 ng/ml) were higher than those in the first trimester of pregnancy (11.0 ± 2.8 ng/ml, n = 5), as previously reported. However, percent free leptin did not change significantly throughout pregnancy. Percent free leptin correlated with total leptin concentrations (ng/ml) in non-pregnant women (r = 0.727, P<0.0001), but not in women in the third trimester of pregnancy (r = 0.006). Constant percent free leptin during pregnancy despite increased leptin concentrations indicates increased leptin binding capacity in pregnant women, that might partly contribute to the establishment of leptin resistance. On the other hand, soluble leptin receptor concentrations showed significant negative correlation with BMI and plasma leptin concentrations in pregnant women (r = -0.470, P<0.01 and r = -0.493, P<0.01, respectively) but not in non-pregnant women. These data suggest the possibility that soluble leptin receptor is a minor component of leptin binding capacity in the plasma of pregnant women.

show abstract

A positive umbilical venous-arterial difference of leptin level and its rapid decline after birth

Cited by 95 publications

References 22 publications

Leptin levels at birth and in early postnatal life in small- and appropriate-for-gestational-age infants

Leptin levels at birth and in early postnatal life in small- and appropriate-for-gestational-age infants

Modulation of susceptibility to weight gain and insulin resistance in low birthweight rats by treatment of their mothers with leptin during pregnancy and lactation

Free-to-Total Leptin Ratio in Maternal Plasma is Constant Throughout Human Pregnancy

Contact Info

Product

Resources

About