A possible beneficial effect of metronidazole in reducing TPN-associated liver function derangements

Daily Ciprofloxacin Treatment for Patients with Advanced Liver Disease Awaiting Liver Transplantation Reduces Hospitalizations

“…Perhaps also relevant to the discrepancy in findings was the trend towards higher serum AST values in ciprofloxacin-treated patients (which may reflect increased hepatic oxidative stress with these agents) that was not reported in previous animal studies [14]. Also to be considered are data indicating that enteric flora produce cytokines and growth regulators that effect hepatic regeneration and function [15][16][17]. Whether ciprofloxacin alters rodent but not human enteric flora in a manner that results in improved hepatic function in one species but not the other requires further study.…”

Parenteral Nutrition-Associated Liver Disease in Pediatric Patients: Strategies for Treatment and Prevention

“…Signifi cant correlation has been reported between bacterial overgrowth and cholestasis and PN dependence [ 38 , 39 ]. In 1985, Freund and colleagues examined the effect of oral metronidazole on hepatic dysfunction during PN administration in rats [ 40 ]. The administration of metronidazole at a dose of 15 mg/kg/day signifi cantly decreased the hepatic lipid content, suggesting the possible involvement of anaerobic bacteria as part of the multifactorial pathogenesis of PNALD.…”

Non-alcoholic steatohepatitis: physiopathological, clinical and therapeutic implications

“…En ratas recibiendo nutrición parenteral total, la administración de polimixina B y metronidazol disminuyó el grado de esteatosis hepática y redujo la producción de TNF-α; la mayor parte de este proviene de las células de Kuppfer, que podían haber sido activadas por endotoxinas (115,116).…”

“…In rats receiving total parenteral nutrition the administration of polymixin B and metronidazole reduced the degree of hepatic steatosis and TNF-α production, most of which comes from Kuppfer cells that might have been activated by endotoxins (115,116).…”