2007
DOI: 10.1002/oa.941
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A possible case of renal osteodystrophy in a skeleton from medieval Wharram Percy, England

Abstract: The skeletal remains of a child aged 13-15 years, recovered from Wharram Percy, England, and dating from AD 960-1700, were examined using gross observation, radiography and scanning electron microscopy. Lesions suggestive of renal osteodystrophy were found. Palaeopathological recognition of renal disease has hitherto relied upon the identification of soft tissue lesions or the presence of urinary calculi. This appears to be the first palaeopathological identification of renal insufficiency on the basis of skel… Show more

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Cited by 10 publications
(4 citation statements)
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“…This may be the case if they illustrate aspects not well-covered in standard palaeopathology text books (e.g. renal osteodystrophy: Mays & Turner-Walker, 2008). Provided that one or more of the above conditions are satisfied and, in addition, description and illustration of lesions is thorough, histological study and medical imaging are used if appropriate, the distribution of lesions in surviving skeletal elements is illustrated, and differential diagnosis is rigorous and takes account of the latest relevant medical literature, the case study still has a valid place in palaeopathology.…”
Section: Discussionmentioning
confidence: 99%
“…This may be the case if they illustrate aspects not well-covered in standard palaeopathology text books (e.g. renal osteodystrophy: Mays & Turner-Walker, 2008). Provided that one or more of the above conditions are satisfied and, in addition, description and illustration of lesions is thorough, histological study and medical imaging are used if appropriate, the distribution of lesions in surviving skeletal elements is illustrated, and differential diagnosis is rigorous and takes account of the latest relevant medical literature, the case study still has a valid place in palaeopathology.…”
Section: Discussionmentioning
confidence: 99%
“…Less commonly, the entire skeleton was imaged to characterize a suspected disease process or to provide as complete an assessment as possible. Such complete evaluations of individual skeletons have shown, for example, diffuse skeletal lesions consistent with syphilis (Mansilla & Pijoan, 1995); lytic lesions (Lewis, 1998); erosions suggestive of juvenile arthritis (Rothschild et al, 1997); evidence for osteogenesis imperfecta (Cope & Dupras, 2011); skeletal stigmata of child abuse (Blondiaux et al, 2002; Wheeler et al, 2013); diffuse cortical porosity and subperiosteal bone deposition felt to represent renal osteodystrophy (Mays & Turner‐Walker, 2008); lytic lesions suggestive of acute lymphocytic leukemia (Isidro et al, 2019); and metabolic deficiency (Wheeler et al, 2013). Such studies reveal the importance of imaging the entire skeleton, as minor lesions may not be visible macroscopically on bone surfaces (Western & Bekvalac, 2015).…”
Section: Literature Review: Resultsmentioning
confidence: 99%
“…For example by aiding future workers who may encounter similar conditions by illustrating lesions characteristic of a particular disease, or issues of differential diagnosis, in more detail than available in the existing literature (e.g. Roberts et al ., 2006; Mays & Turner‐Walker, 2008). In this way, although it may (and probably should) decline in numbers, the case study will continue to advance the discipline.…”
Section: Discussionmentioning
confidence: 99%