A possible cause of Alzheimer’s dementia – Industrial soy foods

Roccisano, Dante; Henneberg, Maciej; Saniotis, Arthur

doi:10.1016/j.mehy.2013.11.033

Cited by 10 publications

(8 citation statements)

References 19 publications

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“…Industrial soy foods have been implicated as a possible cause of Alzheimer’s disease with a log–log correlation of soy consumption and Alzheimer’s disease mortality of r = 0.24, p < 0.05 (132). It was long thought that large macromolecules do not pass directly from the digestive tract to the circulatory system.…”

Section: The Case Against Soy-based Therapeutic Infant Formulasmentioning

confidence: 99%

Soy-Based Therapeutic Baby Formulas: Testable Hypotheses Regarding the Pros and Cons

Westmark

2017

Front. Nutr.

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Soy-based infant formulas have been consumed in the United States since 1909, and currently constitute a significant portion of the infant formula market. There are efforts underway to generate genetically modified soybeans that produce therapeutic agents of interest with the intent to deliver those agents in a soy-based infant formula platform. The threefold purpose of this review article is to first discuss the pros and cons of soy-based infant formulas, then present testable hypotheses to discern the suitability of a soy platform for drug delivery in babies, and finally start a discussion to inform public policy on this important area of infant nutrition.

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Section: The Case Against Soy-based Therapeutic Infant Formulasmentioning

confidence: 99%

Soy-Based Therapeutic Baby Formulas: Testable Hypotheses Regarding the Pros and Cons

Westmark

2017

Front. Nutr.

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“…Therefore, humans consuming meat from animals fattened on grain may have elevated levels of omega-6 fatty acids in the body, making them susceptible to coronary heart disease. High pro-inflammatory mediators in the body resulting from the consumption of diets high in omega-6 fatty acids could also cause other health issues involving cancer, diabetes and Alzheimer's Dementia [26] [57].…”

Section: Rise Of Non-communicable Diseasesmentioning

confidence: 99%

Dietary Fats and Oils: Some Evolutionary and Historical Perspectives Concerning Edible Lipids for Human Consumption

Roccisano¹,

Kumaratilake²,

Saniotis³

et al. 2016

FNS

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Consumption of fats and oils in the ancient world was examined as a window to human nutritional needs and compared with lipid usage in the modern world, post-1900. In earlier periods, the natural and only source of edible fats and oils came from both animals and plants. These fats and oils played a vital role in the evolution of the human body structure, supporting many biochemical functions. Artifacts from prehistoric periods and the ancient world had indicated that humans were evolutionarily adapted to consume saturated lipids. They also consumed unsaturated fats and oils extracted from animals and plants, now identified as omega-3 to omega-6 in the fatty acid ratio of 1:1, commonly derived from naturally consumed unprocessed products and food sources. These fats and oils assisted in providing the ingredients for the building up of cells and maintaining their structural integrity in tissues, including the brain and other important internal organs, as well as providing energy for many biochemical processes in the body. The double bonds distributed throughout fatty acid carbon chains are a characteristic of unsaturated vegetable oils. They are more structurally diverse in polyunsaturated fats and oils with the greater preponderance for carbon-to-carbon double bonds distributed in the carbon chains. These double bonds are susceptible to generating free radicals. This article considers potential problems that proponents of the prevailing diet-heart cholesterol paradigm of the past 60 years may have neglected. It also presents the possible consequences of abandoning the evolutionarily inherited foods containing extracted natural saturated and monounsaturated fats and oils. Furthermore, the article addresses the contribution of docosahexaenoic and eicosapentaenoic acids to immunity and the possible * Corresponding author. D. Roccisano et al. 690 connection of excess consumption of omega-6 fatty acid to the marked rise in obesity and other non-communicable diseases in modern civilization.

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“…Furthermore, phytoestrogens such as genistein and daidzein may decrease DNA methylation in the BRCA1 genome [ 66 , 67 ]. On the contrary, however, it is also noted that consumption of soy food products may contribute to the increasing risk of Alzheimer’s dementia [ 68 ].…”

Section: Some Diets Involved In Tumor Suppressor Expression May Comentioning

confidence: 99%

BRCA1 and p53 Tumor Suppressor Molecules in Alzheimer’s Disease

Nakanishi

Minami

Kitagishi

et al. 2015

IJMS

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Tumor suppressor molecules play a pivotal role in regulating DNA repair, cell proliferation, and cell death, which are also important processes in the pathogenesis of Alzheimer’s disease. Alzheimer’s disease is the most common neurodegenerative disorder, however, the precise molecular events that control the death of neuronal cells are unclear. Recently, a fundamental role for tumor suppressor molecules in regulating neurons in Alzheimer’s disease was highlighted. Generally, onset of neurodegenerative diseases including Alzheimer’s disease may be delayed with use of dietary neuro-protective agents against oxidative stresses. Studies suggest that dietary antioxidants are also beneficial for brain health in reducing disease-risk and in slowing down disease-progression. We summarize research advances in dietary regulation for the treatment of Alzheimer’s disease with a focus on its modulatory roles in BRCA1 and p53 tumor suppressor expression, in support of further therapeutic research in this field.

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A possible cause of Alzheimer’s dementia – Industrial soy foods

Cited by 10 publications

References 19 publications

Soy-Based Therapeutic Baby Formulas: Testable Hypotheses Regarding the Pros and Cons

Soy-Based Therapeutic Baby Formulas: Testable Hypotheses Regarding the Pros and Cons

Dietary Fats and Oils: Some Evolutionary and Historical Perspectives Concerning Edible Lipids for Human Consumption

BRCA1 and p53 Tumor Suppressor Molecules in Alzheimer’s Disease

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