A possible link between ankylosing spondylitis and periodontitis: a systematic review and meta-analysis

Ratz, Tiara; Dean, Linda E; Atzeni, Fabiola; Reeks, Christopher; Macfarlane, Gary J.; Macfarlane, Tatiana V.

doi:10.1093/rheumatology/keu356

Cited by 20 publications

(25 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On meta-analysis, the risk of developing AS in those with periodontitis was almost double with an overall odds ratio of 1.85 (CI 1.72-1.98). Despite no significant difference in probing depth and Clinical attachment level (CAL), there was a significant association in Bleeding on probing (BOP) with those with AS (p = 0.0005) [18].…”

Section: Periodontitis and Ankylosing Spondylitismentioning

confidence: 96%

“…However, the most significant limitation is that there is no single gold standard definition of a threshold for a diagnosis of 'periodontitis'. Most studies use varying thresholds which has a significant impact on prevalence rates and means studies need to be compared with caution [18]. …”

Section: Measures Of Periodontitismentioning

confidence: 99%

“…Ratz et al performed a meta-analysis in 2015 of 6 studies comparing periodontitis measures in cases of AS and controls, and ranging in size between 90 and 40,926 participants [18]. All studies showed a positive correlation between AS and periodontitis severity, but only two showed statistical significance.…”

Section: Periodontitis and Ankylosing Spondylitismentioning

confidence: 99%

See 2 more Smart Citations

Periodontal Disease and Autoimmunity: What We Have Learned from Microbiome Studies in Rheumatology

Rutter-Locher¹,

Fuggle²,

Orlandi³

et al. 2017

Periodontitis - A Useful Reference

View full text Add to dashboard Cite

The oral cavity is home to vast populations of commensal microbial organisms which constitute the 'healthy oral microbiome.' Periodontitis is a destructive, infectious, inflammatory condition affecting the gums. Initially, a biofilm structure develops, causing localized inflammation. This biofilm is then colonized by certain anaerobic bacteria, including the 'red complex' organisms. There is an increasing interest in the communication between these organisms and host immune surveillance, a dialog which may plays an important role in the development of autoimmune diseases. Studies have shown an association between periodontitis and other inflammatory conditions including rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis and systemic lupus. The advent of accessible 16S ribosomal sequencing has led to exciting developments in the characterization of the human microbiome and the ability to study this interaction in more detail. The transmucosal communication between periodontitis and host immunity may provide avenues of discovery regarding the etiology and progression of rheumatic diseases.

show abstract

Section: Periodontitis and Ankylosing Spondylitismentioning

confidence: 96%

Section: Measures Of Periodontitismentioning

confidence: 99%

See 1 more Smart Citation

Periodontal Disease and Autoimmunity: What We Have Learned from Microbiome Studies in Rheumatology

Rutter-Locher¹,

Fuggle²,

Orlandi³

et al. 2017

Periodontitis - A Useful Reference

View full text Add to dashboard Cite

show abstract

“…Ankylosing spondylitis (AS) and periodontal disease (PD) are chronic inflammatory disorders that share local and systemic inflammatory as well as destructive events, targeting specific tissues such as joints and enthesis in AS, while periodontal tissues in PD [1][2][3]. The underlying pathobiologic pathways emphasize a complex immune dysregulation with excess of pro-inflammatory cytokines including TNF-α and IL-6 in both articular and periodontal environments, indicating potential association of these entities [1][2][3][4][5].…”

Section: Abstract: Ankylosing Spondylitis Periodontitis Tnf Antagonmentioning

confidence: 99%

“…Although three main criteria are largely accepted for the clinical diagnosis of periodontitis, including clinical attachment loss (CAL), bleeding on probing (BOP) and pocket probing depth (PPD), a uniform definition of the diagnostic threshold has not yet been established. Thus, the true rate of periodontitis in general population largely varies according to the definition used [4,5,7,9].…”

Section: Abstract: Ankylosing Spondylitis Periodontitis Tnf Antagonmentioning

confidence: 99%

Periodontal Disease in Patients with Ankylosing Spondylitis: myth or reality?

Iordache¹,

Chirieac²,

Ancuta³

et al. 2017

Rev. Chim.

View full text Add to dashboard Cite

Although the relation between periodontitis (PD) and systemic disorders (e.g. cardiovascular diseases, diabetes and rheumatoid arthritis) is widely accepted, the association with ankylosing spondylitis (AS) is inconsistently mentioned. We prospectively examined the relationship between periodontal disease and AS, focusing on the rate and course of PD, factors associated with severity and the impact of anti-TNF-α treatment on inflammatory status. Standard assessments performed twice (week 0, week 24) included an extensive dental evaluation (plaque index, gingival index, bleeding on probing, periodontal pocket depth, clinical attachment loss), inflammatory parameters and AS activity scores (BASDAI, ASDAS-CRP). More than half of AS presented with impaired periodontal health at baseline (mild to moderate PD) meaning increased sites with dental plaque, abnormal bleeding, increased periodontal pocket depth and clinical attachment loss. Significant positive correlation between presence and severity of PD, AS activity and systemic inflammation (CRP) was reported at baseline (p<0.05). A final analysis performed at 24 weeks revealed significant improvement in periodontal status, inflammatory parameters and AS activity, suggesting efficacy of TNF inhibitors directed not only against systemic, but also on local (articular, periodontal) inflammation (p<0.05). Patients with AS are at risk to develop periodontal disease, particularly those with high levels of systemic inflammation. Benefits of anti-TNFα therapy in the particular settings of AS patient and concomitant periodontal disease should be validated through further studies in larger cohorts.

show abstract

Smoking and spondyloarthritis: a bad connection

Wendling

Prati

2015

Rheumatol Int

View full text Add to dashboard Cite

A possible link between ankylosing spondylitis and periodontitis: a systematic review and meta-analysis

Abstract: The results led to the need for a further large study with sufficient statistical power to detect the desired effect size, taking into account potential confounding factors and using validated measures of AS and periodontitis.

Cited by 20 publications

References 34 publications

Periodontal Disease and Autoimmunity: What We Have Learned from Microbiome Studies in Rheumatology

Periodontal Disease and Autoimmunity: What We Have Learned from Microbiome Studies in Rheumatology

Periodontal Disease in Patients with Ankylosing Spondylitis: myth or reality?

Smoking and spondyloarthritis: a bad connection

Contact Info

Product

Resources

About