A possible link between exercise-training adaptation and dehydroepiandrosterone sulfate- an oldest-old female study

Huang, Yi-Jen; Chen, Mu-Tsung; Fang, Chaojun; Lee, Wen‐Chih; Yang, Sun-Chin; Kuo, Chia‐Hua

doi:10.7150/ijms.3.141

Cited by 19 publications

(14 citation statements)

References 31 publications

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“…This is a common finding in very old populations and is mainly due to malnutrition. 20,21) Complications and outcome: The reported rates of vascular and bleeding complications, peri-interventional infarction, and cerebrovascular stroke were comparable with the percentages described by Batchelor, et al…”

Section: Discussionsupporting

confidence: 66%

Comorbidities and Complications in Nonagenarians Undergoing Coronary Angiography and Intervention

et al. 2017

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SummaryElderly people represent the fastest growing portion of cardiovascular patients. We aimed to analyze the clinical presentation, risk factors, co-morbidities, complications, and mortality in patients 90 years or more who underwent coronary angiography and intervention.We retrospectively studied 108 (0.25% of 43,385) consecutive patients ≥ 90 years undergoing cardiac catheterization and/or intervention in a tertiary specialist hospital between 2003 and 2014.Most patients (68.5%) were introduced on an emergency basis, especially with acute coronary syndrome (ACS) (63.8%). Non-STEMI accounted for two-thirds of the myocardial infarctions. We found higher prevalences of previous coronary artery disease (CAD) (38%), other atherosclerotic diseases (20.4%), cardiac risk factors such as hypertension (84.3%), diabetes (49.1%), hyperlipidemia (50.9%), heart failure (42.6%), atrial fibrillation (AF) (25.0%), severe aortic stenosis (13.0%), severe mitral regurgitation (3.7%), and implantable devices (25.0%), and co-morbidities such as renal impairment (48.1%), COPD (12.0%), and previous stroke (6.5%). Three-vessel disease was present in 34.6% of the patients. The left anterior descending artery (LAD) was the most affected coronary artery (67.6%). Percutaneous coronary intervention (PCI), mostly with bare metal stents (BMS), was used to manage 54.6% of the patients, and it failed in 4 of the patients. Conservative treatment was used in 39.8% of the patients and 15.7% had no significant CAD.The incidences of vascular complications, such as bleeding (6.5%), bleeding in other organs (6.5%), blood transfusion (6.5%), in-hospital paroxysmal atrial fibrillation (7.4%), in-hospital successful reanimation (2.8%), complete heart block (5.6%), acute renal impairment (23.1%), associated infection (25.9%), cardiogenic shock (14.8%), and death (15.7%) were high.Considering the more extensive risk factors, CAD and co-morbidities, acute presentation and age per se, we believe that the reported higher rates of complications and mortality are still acceptable. (Int Heart J 2017; 58: 180-184)

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Section: Discussionsupporting

confidence: 66%

Comorbidities and Complications in Nonagenarians Undergoing Coronary Angiography and Intervention

et al. 2017

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“…However, the prevalence of hyperlipidemia was significantly lower among patients older than 90 years. This is a common finding in very old populations and mainly due to malnutrition [18],[19]. Although women are known to have a longer live expectancy we found no gender predominance in our series.…”

Section: Discussionsupporting

confidence: 42%

Cardiac catheterisation in nonagenarians: Single center experience

Ohlow

Hassan²,

Lotze³

et al. 2012

Journal of Geriatric Cardiology

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ObjectiveTo explore the treatment, procedure related risks, and outcomes of patients older than 90 years of age undergoing cardiac catheterization.MethodsWe retrospectively studied 32 patients ≥ 90 years (93.0 ± 1.2 years) who underwent cardiac catheterisation in a tertiary specialist hospital (0.2% of 14,892 procedures during three years). The results were compared to a patient cohort younger than 90 years of age.ResultsBaseline characteristics revealed a higher prevalence of diabetes (P < 0.001), chronic obstructive pulmonary disease (P < 0.04), previous myocardial infarction (P < 0.02), and complex coronary anatomy (SYNTAX score 33 vs. 19) in nonagenarians. Patients < 90 years of age showed more hyperlipidemia (P < 0.01) and previous percutaneous coronary interventions (P < 0.015). Nonagenarians underwent coronary angiography more often for acute coronary syndrome (ACS) (P < 0.003), were presented more often in cardiogenic shock (P < 0.003), and were transferred faster to coronary angiography in cases of ACS (P < 0.0001). The observed in-hospital mortality rate (13% study group vs. 1% control group; P < 0.003) in nonagenarians was lower than the calculated rate of thrombolysis in myocardial infarction (TIMI) and global registry of acute cardiac events (GRACE) mortality and strongly influenced by the severity of clinical presentation and the presence of co-morbidities.ConclusionDespite the common scepticism that cardiac catheterisation exposes patients ≥ 90 years to an unwarranted risk, our data demonstrate an acceptable incidence of complications and mortality in this group of patients.

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“…In contrary, another previous study with a group of 16 women, aged 80-93 years, who participated in an exercise test 4-month intervention, there was no change in SaO2 [12].…”

Section: Discussioncontrasting

confidence: 42%

Sustained Improvement of Arterial Blood Oxygenation, Maximum Oxygen Consumption and Maximum Walking Distance after Treadmill Training in Healthy Elderly Subjects?

Bichay¹,

Allam²,

Fernández

et al. 2013

TOPHJ

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Background. Physical activity is known to play an important role in improving the cardio-pulmonary function and arterial blood oxygenation (SaO2) in elderly subjects. Objective. To evaluate the therapeutic efficacy of treadmill training on SaO2, maximum oxygen consumption (VO 2 max ) and maximum walking distance in elderly healthy subjects. Design. Intervention study Setting. El Salam General Hospitals, Cairo (Egypt). Participants. Our study included 41 subjects. All participants appeared healthy, without chronic diseases and passed the Cardiopulmonary Exercise Test. Intervention. Participants were incorporated in a treadmill-training program of moderate intensity to attain a fraction of 60% to 70% of the maximum heart rate. After 12 weeks of controlled physical activity, the program was made voluntarily for 36 weeks. Measurements. SaO2, VO 2 max and maximum walking distance were measured for each individual one-week before and 12 weeks after training and at the 30 th and the 48 th week of the program. Results. Our study included 20 men and 21 women, with mean age of 65.1 + 2.7 years (Range 60-69). An increase in the mean values of SaO2, VO 2 max and maximum walking distance after 12 weeks of controlled exercise and also at the 30 th week and the 48 th week of the program (P<0.05). There has been a decrease in the mean values of VO 2 max , SaO2 and maximum walking distance after the 30 th and 48 th week in comparison with the values after the first 12 weeks. Conclusion. Controlled treadmill training for 12 weeks improved SaO2, VO 2 max and maximum walking distance of the participants. The mean values of the participants decreased after the 30 th and 48 th week due to lack of adherence to the unsupervised program.

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A possible link between exercise-training adaptation and dehydroepiandrosterone sulfate- an oldest-old female study

Cited by 19 publications

References 31 publications

Comorbidities and Complications in Nonagenarians Undergoing Coronary Angiography and Intervention

Comorbidities and Complications in Nonagenarians Undergoing Coronary Angiography and Intervention

Cardiac catheterisation in nonagenarians: Single center experience

Sustained Improvement of Arterial Blood Oxygenation, Maximum Oxygen Consumption and Maximum Walking Distance after Treadmill Training in Healthy Elderly Subjects?

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