A possible mechanism for anxiolytic and antidepressant effects of alpha- and beta-amyrin from Protium heptaphyllum (Aubl.) March

Aragão, Gislei Frota; Carneiro, Lyvia Maria Vasconcelos; Júnior, Antônio P. F.; Vieira, Lorena Carla; Bandeira, Paulo Nogueira; Lemos, Telma L. G.; Viana, Glauce Socorro de Barros

doi:10.1016/j.pbb.2006.11.019

Cited by 112 publications

(73 citation statements)

References 22 publications

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“…Our results are in agreement with the reported literature where flavonoids -quercetin, 18 kaempferol 19 and apigenin; 20 and triterpenoids -galphimine A, galphimine B 21 and α, β-amyrin 22 have been reported to exhibit anxiolytic activity. It is finally suggested that flavonoids and / or triterpenoids are responsible for anxiolytic activity of A. pindrow aerial parts.…”

Section: Discussionsupporting

confidence: 94%

Screening of Antianxiety Activity of Abies pindrow Royle Aerial Parts

Kumar¹,

Kumar²

2015

IJPER

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Abies pindrow Royle (Himalayan Silver Fir; Pinaceae) has been traditionally used for the treatment for anxiety but the plant has not been systematically investigated to validate its traditional claims. Thus, it was planned to investigate antianxiety activity of various extracts and fractions of A. pindrow aerial parts using elevated plus maze model (EPM). Properly identified A. pindrow aerial parts were successively and exhaustively extracted using solvents in increasing order of polarity viz., n-hexane, chloroform, methanol and water. All crude extracts were subjected to antianxiety activity at the doses of 100, 200 or 400 mg/kg, p.o. in mice. Efficacy of A. pindrow was statistically compared with the standard anxiolytic drug, diazepam (2 mg/kg, i.p.). Amongst various extracts, chloroform and methanol extract exhibited significant antianxiety activity with respect to control, and statistically equivalent to the standard drug at the dose of 200 and 400 mg/kg, respectively. The bioactive methanol extract was partitioned successively using solvents in increasing order of polarity viz., n-hexane, ethyl acetate and 1-butanol. All fractions were also subjected to antianxiety activity at the doses of 25 or 50 mg/kg, p.o. in mice. Only ethyl acetate fraction (EAF) exhibited significant antianxiety activity equivalent to the standard drug at the dose 50 mg/kg. Present studies scientifically validated traditional claims of A. pindrow for antianxiety activity. Flavonoids of A. pindrow aerial parts have been suggested to play role in treating anxiety disorders.

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Section: Discussionsupporting

confidence: 94%

Screening of Antianxiety Activity of Abies pindrow Royle Aerial Parts

Kumar¹,

Kumar²

2015

IJPER

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“…Marchand, Burseraceae, is a medicinal plant largely found in the North and Northeast of Brazil, it is popularly known as "breu branco", and popularly used for inflammations, pain, ulcers and wounds. The triterpenes isolated from several species of medicinal plants are, in general, responsible, at least in part, for their biological activities (Aragão et al, 2006), including anti-inflammatory, anti-ulcer, anti-hyperlipidemic, anti-tumor, and hepatoprotective (Oliveira et al, 2005). Essential oils are complex mixtures comprising many single compounds, chemically derived from terpenes and their oxygenated compounds, these constituents contribute to the antifungal, antiviral, antioxidant effects (Laciar et al, 2009;Aidi et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Gastroprotective effects of essential oil from Protium heptaphyllum on experimental gastric ulcer models in rats

Araujo¹,

Takayama²,

de-Faria³

et al. 2011

Rev. bras. farmacogn.

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Peptic ulcers are a common disorder of the entire gastrointestinal tract, its etiology has not been completely elucidated. The basic physiopathological of peptic ulcers result from an imbalance between some endogenous aggressive factor and cytoprotective factors. The treatment of this disease is usually done with antacids or proton pump, but are currently being used plants derivated compounds. We evaluated the gastroprotective properties and its possible mechanisms of action of the essential oil from Protium heptaphyllum (Aubl.) Marchand, Burseraceae (BB). The formation of ulcers, were evaluated in three experimental models, through the induction of gastric lesions by ethanol, nonsteroidal anti-infl ammatory drugs and acetic acid. The mechanisms of action were evaluated through the pylorus ligature experiment, western blot, GSH, GR, SOD, GPx, MDA and MPO activities. BB signifi cantly inhibited the formation of ulcers induced by the three different models, increased the GSH and GR levels and maintained the same levels of SOD and GPx of the sham group, inhibited MPO and MDA, did not produce signifi cant modifi cation in gastric juice content and showed increased COX-2 and EGF. BB exerts its gastroprotective activity, possibly, by increasing COX-2 and EGF expression and due to its possible antioxidant property.

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“…Despite results showing that use value for the plant set is not related with its environmental availability, this may be detected for some species (Ferraz et al, 2006). Besides, P. heptaphyllumis frequently cited by different populations for several types of use (Pasa, Soares, & Guarim-Neto, 2004, Cunha & Albulquerque, 2006, Crepaldi & Peixoto, 2010, also being reported its use in pharmacology (Oliveira et al, 2005, Aragão et al, 2006. This species presents wide distribution in Brazil (Daly, 2014) abundant species on restinga (Assumpção & Nascimento, 2000, Assis et al, 2004.…”

Section: Resultsmentioning

confidence: 99%

<b>Useful woody species and its environmental availability: the case of artisanal fishermen in Itaúnas, Brazil

Lopes

Crepaldi

Lobão

2017

Acta Sci. Biol. Sci.

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ABSTRACT. Ethnobotanical studies involve research with human societies and their different interaction with plants, and the quantitative approaches from thes estudies are important to select conservation priority of species in natural environment. This research aims to quantify use-values for woody plants mentioned by fishers in Itaúnas, state of Espírito Santo, and evaluate the relationship between use-values and species availability (absolute density and frequency, and importance value) in two distinct resting vegetation formations. It also proposes to identify priority species for conservation. It was selected 30 species cited in individual semi-structured interviews with key-informant in fishers' community and who were also on list of structural survey of two vegetation phytophysiognomies in the restinga regions. The data used was collected in previously published work. It was performed a correlation analysis between use-values and structural parameters of the mentioned woody species. Protium heptaphyllum, P. icicariba and Byrsonima sericea present the highest use-values. It was not observed relation between use-value and species availability in each vegetation formation. It was classified two and eight species as priority for conservation on shrubby and forest formations, respectively.Keywords: structural characteristics, ethnobotany, Itaúnas State Park, restinga, use-value (UV).Espécies lenhosas úteis e sua disponibilidade no ambiente: o caso dos pescadores artesanais em Itaúnas, Brasil RESUMO. Estudos etnobotânicos envolvem pesquisas com sociedades humanas e suas diferentes interações com as plantas, e abordagens quantitativas deste estudos são importantes para selecionar prioridades de conservação das espécies nos ambientes naturais. Esta pesquisa objetiva quantificar os valores de uso das plantas citadas por pescadores em Itaúnas, Espírito Santo, e avaliar as relações entre os valores de uso a disponibilidade das espécies (densidade e frequência absoluta e valor de importância) em duas formações vegetais distintas de restinga. É também proposto identificar o índice de prioridade de conservação das espécies. Foram selecionadas 30 espécies citadas em entrevistas individuais semiestruturadas com informantes-chave na comunidade de pescadores e que também estavam em listas de levantamentos estruturais de duas fitofisionomias vegetais de restinga na região. Os dados utilizados foram coletados em trabalhos previamente publicados. Foi feita a análise de correlação entre os valores de uso e os parâmetros estruturais das espécies lenhosas mencionadas. Protium heptaphyllum, P. icicariba e Byrsonima sericea apresentaram o maior valor de uso. Não foi observado relação entre o valor de uso a disponibilidade das espécies em cada formação vegetal. Foram classificadas duas e oito espécies para prioridade de conservação nas formações arbustivas e florestais respectivamente.Palavras-chave: características estruturais, etnobotânica, Parque Estadual de Itaúnas, restinga, valor de uso.

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A possible mechanism for anxiolytic and antidepressant effects of alpha- and beta-amyrin from Protium heptaphyllum (Aubl.) March

Cited by 112 publications

References 22 publications

Screening of Antianxiety Activity of Abies pindrow Royle Aerial Parts

Screening of Antianxiety Activity of Abies pindrow Royle Aerial Parts

Gastroprotective effects of essential oil from Protium heptaphyllum on experimental gastric ulcer models in rats

<b>Useful woody species and its environmental availability: the case of artisanal fishermen in Itaúnas, Brazil

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