A possible mechanism of antidepresant activity of beta-amyrin palmitate isolated from lobelia inflata leaves in the forced swimming test

Subarnas, Anas; Tadano, Takeshi; Nakahata, Norimichi; Arai, Yasuhiko; Kinemuchi, Hiroyasu; Oshima, Yoshiteru; Kisara, Kensuke; Ohizumi, Yasushi

doi:10.1016/0024-3205(93)90220-w

Cited by 45 publications

(36 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The forced swimming test is widely used for the assessment of antidepressant-like activity in animal models. The shortening of immobility duration indicates antidepressant activity in this model, while prolonged immobility time reflects a CNS depression-like effect [35]. However, CNS depressant effect was observed in the forced swimming test.…”

Section: Discussionmentioning

confidence: 80%

Evaluation of central nervous system (CNS) depressant activity of methanolic extract of Commelina diffusa Burm. in mice

2018

View full text Add to dashboard Cite

Background: Commelina diffusa Burm. (Family: Commelinaceae) is usually known as "climbing dayflower or spreading dayflower" in Bangladesh. The plant is used in fever, malaria, insect, bug bites, rheumatoid arthritis, gonorrhea, influenza, and bladder infection etc. The present investigation was undertaken which deals with the evaluation of central nervous system (CNS) depressant activity of methanolic extract of C. diffusa in mice models.

show abstract

Section: Discussionmentioning

confidence: 80%

Evaluation of central nervous system (CNS) depressant activity of methanolic extract of Commelina diffusa Burm. in mice

2018

View full text Add to dashboard Cite

show abstract

“…The forced swimming test is frequently used for the assessment of antidepressant-like activity in animal models. The shortening of immobility duration indicates antidepressant activity in this model, while prolonged immobility duration reflects a CNS depression-like effect (42). No significant antidepressant effect was observed; however, a dose-dependent CNS depression was observed in the forced swimming test.…”

Section: Discussionmentioning

confidence: 78%

Neuropharmacological effects of methanolic extracts of Rubus fruticosus L.

Uddin

Hussain²,

Khan³

et al. 2014

Turk J Med Sci

View full text Add to dashboard Cite

Leguminous crops suffer severely in soils poor in phosphorus. A 2-factor factorial experiment was conducted in a net-house to explore the effect of graded levels of P fertilizer (0, 30, and 60 kg P ha -1 or P 0 , P 30 , and P 60 , respectively) together with rhizobium (biological nitrogen fertilizer (BNF)) and/or phosphate-solubilizing bacteria (biological phosphorus fertilizer (BPF)) in terms of nutrient uptake, yield, and quality of chickpea (Cicer arietinum L.). Phosphorus was applied as basal dose, while seeds were treated with respective biofertilizer(s) before sowing according to the treatments [BF 0 (control), BNF, BPF, and BNF+BPF]. Concerning the main effects, P 60 proved superior or equivalent to P 30 , while among the biofertilizer treatments, BNF+BPF gave the greatest values for nutrient uptake as well as for yield and quality parameters. The interaction between P levels and biofertilizer treatments was generally significant. 30 kg P ha -1 applied with N and P biofertilizers (P 30 × BNF+BPF) was the most profitable interaction for N uptake as well as for yield and quality characteristics. Compared to P 60 applied alone (P 60 × BF 0 ), P 30 × BNF+BPF resulted in greater N uptake (27.3%), seed yield (21.1%), and the content of seed protein (2.9%) and carbohydrate (5.6%). Furthermore, P 30 × BNF+BPF was statistically equal to P 60 × BNF+BPF with regard to N uptake, seed yield, and protein content as well as for most yield components. Thus, P 30 × BNF+BPF saved 30 kg P ha -1 of the costly inorganic P fertilizer to achieve the greatest crop yield and quality.

show abstract

“…The forced swim test is an animal model widely used for the assessment of drugs with antidepressant property. The test is based on the observation that animals forced to swim in water from which they cannot escape eventually assume a characteristic immobile posture devoid of any activity [12,[19][20][21]. The appearance of immobility therefore reflects a state of tiredness, fatigue or reduced stamina, lowered mood (hopelessness) and the cessation of persistent escape-directed behaviour.…”

Section: Discussionmentioning

confidence: 99%

Psychopharmacological properties of an aqueous extract of Tetracarpidium conophorum Hutch. & Dalziel in mice

Umukoro

2011

J Nat Med

View full text Add to dashboard Cite

The extract of the nut of Tetracarpidium conophorum (TC), commonly known as African walnut, is widely used to relieve pain, increase sperm count, enhance sexual performance in males and as a nerve tonic in ethnomedicine. This study describes the psychopharmacological properties of the aqueous extract of the nut of TC in mice. The spectrum of activities studied were the effects of TC on the duration of immobility in the forced swim test of the behavioural despair model of depression; prolongation of the duration of sleep produced by thiopentone; amphetamine-induced stereotyped behaviour; and on pain episodes produced by acetic acid and by formalin. Orally administered TC (50-200 mg/kg) produced a significant and dose-related decrease in the duration of immobility in the forced swim test in mice. TC also exhibited analgesic property, as shown by its ability to reduce the frequency of abdominal constrictions induced by acetic acid and to inhibit the nociceptive responses produced by formalin. However, at the tested oral doses of 50-200 mg/kg, TC did not prolong the duration of sleep produced by thiopentone nor alter the pattern of the stereotyped behaviour induced by amphetamine. This investigation provides evidence that may support the ethnomedicinal applications of the extract of the nut of TC in the treatment of pain. The study also revealed that TC seems to demonstrate antidepressant-like activity, as evidenced by its ability to shorten the period of immobility in the forced swim test; however, further studies are necessary to clearly define the role of TC in depression.

show abstract

A possible mechanism of antidepresant activity of beta-amyrin palmitate isolated from lobelia inflata leaves in the forced swimming test

Cited by 45 publications

References 10 publications

Evaluation of central nervous system (CNS) depressant activity of methanolic extract of Commelina diffusa Burm. in mice

Evaluation of central nervous system (CNS) depressant activity of methanolic extract of Commelina diffusa Burm. in mice

Neuropharmacological effects of methanolic extracts of Rubus fruticosus L.

Psychopharmacological properties of an aqueous extract of Tetracarpidium conophorum Hutch. & Dalziel in mice

Contact Info

Product

Resources

About