A Possible Mechanism of Protection by Polyamines against Gastric Damage Induced by Acidified Ethanol in Rats: Polyamine Protection May Depend on Its Antiperoxidative Properties

Mizui, Takuji; Shimono, Noriko; Doteuchi, Masami

doi:10.1254/jjp.44.43

Cited by 40 publications

(21 citation statements)

References 27 publications

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“…In the present study, oral administration of celery extract inhibited the gastric damage caused by ethanol and strong alkali, the most commonly employed tests in the evaluation of anti-ulcer/cytoprotective activity (Oliveira et al, 2004). It is suggested that oxygen radicals may contribute to the induction of ethanol and other necrotizing agents-induced gastric mucosal lesions (Trier et al, 1987;Matsumoto et al, 1992) and anti-oxidants are protective against the damage caused by oxidants (Mizui et al, 1987;Farina et al, 1998). Ethanol has been shown to deplete the level of non-protein sulfhydryl content in stomach tissues and its restoration appears to be important in gastroprotection since they provide a substrate for free radicals to replenish GSH stores (Trier et al, 1987).…”

Section: Discussionmentioning

confidence: 54%

Gastric antiulcer, antisecretory and cytoprotective properties of celery (Apium graveolens) in rats

Al‐Howiriny

Alsheikh

Alqasoumi

et al. 2010

Pharmaceutical Biology

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Section: Discussionmentioning

confidence: 54%

Gastric antiulcer, antisecretory and cytoprotective properties of celery (Apium graveolens) in rats

Al‐Howiriny

Alsheikh

Alqasoumi

et al. 2010

Pharmaceutical Biology

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“…HCl/EtOH-induced gastric ulceration has been indicated to be due to neutrophil-generated ROS [23]. In addition, this ulcer has been indicated to be due to impairments in defensive factors such as mucus [24]. Diacerein inhibited the HCl/ EtOH-induced gastric ulceration in a dose-dependent manner.…”

Section: Discussionmentioning

confidence: 99%

Effects of Diacerein on Indomethacin-Induced Gastric Ulceration

2001

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We investigated the effect of diacerein, an antiosteoarthritic agent, and its metabolite, rhein, on the production of reactive oxygen species (ROS) from neutrophils as well as the protective effect of diacerein on indomethacin-induced gastric ulceration and its protection mechanism. Rhein inhibited the ROS production from N-formyl-methionyl-leucyl-phenylalanine or phorbol-12-myristate-13-acetate-activated human peripheral neutrophils. Indomethacin-induced gastric ulceration was significantly inhibited by oxygen radical scavengers and 16,16-dimethyl-prostaglandin E₂ (dmPGE₂) but not by allopurinol. Diacerein inhibited indomethacin-induced gastric ulceration in a dose-dependent manner. Diacerein did not affect the gastric mucosal PGE₂ content. In addition, diacerein inhibited HCl + ethanol-induced gastric ulceration. These data indicate that the inhibitory effect of diacerein on indomethacin-induced gastric ulceration could be mediated not by the augmentation of gastric mucosal PGE₂ production but by the suppression of ROS production based on its inhibition of neutrophil activation.

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“…Related to this aspect, it is known that amines can yield derivatives of phospholipid hydroperoxides in the presence of haem (lio & Yoden, 1988). At a cellular level, the antiperoxidative properties of polyamines were correlated with their protective effect against gastric lesions induced by acidified ethanol (Mizui et al, 1987).…”

Section: Interaction Of Polyamines With Membrane Componentsmentioning

confidence: 99%