A possible novel co-relation of locus 7q11 rs1761667 polymorphism with the severity of preeclampsia in Egyptian pregnant women

Fakhry, Morkoss M.; Abdel-Hamed, Asmaa R.; Abo-Elmatty, Dina M.; Mesbah, Noha M.; Al-Sawaf, Ahmed H.; Ezzat, Omnia; Al-Sawaf, H. A.

doi:10.1016/j.mgene.2020.100650

Cited by 4 publications

(5 citation statements)

References 44 publications

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“…The AA genotype of SNP rs1761667 in the CD36 gene showed a higher prevalence in the obese group than in the normal-weight group [62]. Additionally, the AA genotype was associated with higher levels of serum triglycerides and total cholesterol [42]. In the Jordanian population, Hatmal et al [63] found no association between the CD36 gene and the presence of type 2 diabetes or dyslipidemia.…”

Section: Discussionmentioning

confidence: 98%

“…Moreover, CD36 polymorphisms have been associated with abnormal blood lipid levels [39], increased risk of coronary heart disease in diabetics [40], and increased risk of metabolic syndrome [41]. Among the variants of the CD36 gene, there is a single-nucleotide polymorphism (SNP) known as rs1761667 that involves an A/G substitution [42]. This SNP gives rise to three possible genotypes (AA, AG, and GG) and associated phenotypes [42].…”

Section: Introductionmentioning

confidence: 99%

“…Among the variants of the CD36 gene, there is a single-nucleotide polymorphism (SNP) known as rs1761667 that involves an A/G substitution [42]. This SNP gives rise to three possible genotypes (AA, AG, and GG) and associated phenotypes [42]. Specifically, individuals with the AA genotype of the CD36 rs1761667 polymorphism have elevated levels of serum triglycerides and total cholesterol [42].…”

Section: Introductionmentioning

confidence: 99%

“…This SNP gives rise to three possible genotypes (AA, AG, and GG) and associated phenotypes [42]. Specifically, individuals with the AA genotype of the CD36 rs1761667 polymorphism have elevated levels of serum triglycerides and total cholesterol [42]. In addition, individuals carrying the A allele may undergo changes in lipid metabolism, which increase the risk of pathologies associated with atherosclerosis [43].…”

Section: Introductionmentioning

confidence: 99%

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Genotypic and Allelic Distribution of the CD36 rs1761667 Polymorphism in High-Level Moroccan Athletes: A Pilot Study

El Ouali,

Kartibou,

Del Coso

et al. 2024

Genes

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Previous studies have shown that variations in the CD36 gene may affect phenotypes associated with fat metabolism as the CD36 protein facilitates the transport of fatty acids to the mitochondria for oxidation. However, no previous study has tested whether variations in the CD36 gene are associated with sports performance. We investigated the genotypic and allelic distribution of the single-nucleotide polymorphism (SNP) rs1761667 in the CD36 gene in elite Moroccan athletes (cyclists and hockey players) in comparison with healthy non-athletes of the same ethnic origin. Forty-three Moroccan elite male athletes (nineteen cyclists and twenty-four field hockey players) belonging to the national teams of their respective sports (athlete group) were compared to twenty-eight healthy, active, male university students (control group). Genotyping of the CD36 rs1761667 (G>A) SNP was performed via polymerase chain reaction (PCR) and Sanger sequencing. A chi-square (χ2) test was used to assess the Hardy–Weinberg equilibrium (HWE) and to compare allele and genotype frequencies in the “athlete” and “control” groups. The genotypic distribution of the CD36 rs1761667 polymorphism was similar in elite athletes (AA: 23.81, AG: 59.52, and GG: 16.67%) and controls (AA: 19.23, AG: 69.23, and GG: 11.54%; χ2 = 0.67, p = 0.71). However, the genotypic distribution of the CD36 rs1761667 polymorphism was different between cyclists (AA: 0.00, AG: 72.22, and GG: 27.78%) and hockey players (AA: 41.67, AG: 50.00, and GG: 8.33%; χ2 = 10.69, p = 0.004). Specifically, the frequency of the AA genotype was significantly lower in cyclists than in hockey players (p = 0.02). In terms of allele frequency, a significant difference was found between cyclists versus field hockey players (χ2 = 7.72, p = 0.005). Additionally, there was a predominance of the recessive model in cyclists over field hockey players (OR: 0.00, 95% CI: 0.00–0.35, p = 0.002). Our study shows a significant difference between cyclists and field hockey players in terms of the genotypic and allelic frequency of the SNP rs1761667 of the CD36 gene. This divergence suggests a probable association between genetic variations in the CD36 gene and the type of sport in elite Moroccan athletes.

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Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Genotypic and Allelic Distribution of the CD36 rs1761667 Polymorphism in High-Level Moroccan Athletes: A Pilot Study

El Ouali,

Kartibou,

Del Coso

et al. 2024

Genes

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“…Despite the progress made in miRNA-based therapeutics, there are still challenges to overcome, such as the limitations of current detection methods and the need for more efficient and costeffective approaches. Overcoming these challenges could pave the way for miRNA detection and treatment to enter the clinic smoothly and become a new target for BC treatment [136,137].…”

Section: Combination Therapiesmentioning

confidence: 99%

MiRNAs as Promising Therapeutic Targets for Breast Cancer

Fakhry,

Abdel-Hamed,

Mesbah

et al. 2024

OBM Genet

Self Cite

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Breast cancer (BC) is the most common cause of cancer-related death and is the malignancy most frequently diagnosed in females worldwide. BC incidence is predicted to continue increasing worldwide. Without interventions, annual new cases will reach over 3 million by 2030. Genetic abnormalities account for almost 70% of all BC cases worldwide. Biological pathways implicated include non-coding RNAs (ncRNAs). MiRNAs are small non-coding RNA molecules that play a role in post-transcriptional regulation of gene expression. They can function as either tumor suppressors or oncogenes, and their role depends on the specific miRNA and target genes affected. The research on miRNA-based cancer treatments has yielded promising results. Depending on recent data, the goal of this review was to summarize the mechanisms that explain the role of some miRNAs in BC pathogenesis and drug resistance. However, highlighting the areas needing further exploration and more research is required before using microRNAs in clinical settings.

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CD-36 variants and circulating miRNAs as prognostic biomarkers and potential therapeutic targets in breast cancer patients

Abdel-Hamed,

Fakhry,

Mesbah

et al. 2024

Gene Reports

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A possible novel co-relation of locus 7q11 rs1761667 polymorphism with the severity of preeclampsia in Egyptian pregnant women

Cited by 4 publications

References 44 publications

Genotypic and Allelic Distribution of the CD36 rs1761667 Polymorphism in High-Level Moroccan Athletes: A Pilot Study

Genotypic and Allelic Distribution of the CD36 rs1761667 Polymorphism in High-Level Moroccan Athletes: A Pilot Study

MiRNAs as Promising Therapeutic Targets for Breast Cancer

CD-36 variants and circulating miRNAs as prognostic biomarkers and potential therapeutic targets in breast cancer patients

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