1960
DOI: 10.1073/pnas.46.11.1430
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A Possible Role for Arginine in Enzyme Mechanisms

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Cited by 10 publications
(2 citation statements)
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“…In addition, attention has been called to possible participation, in the catalytic process, of an aspartic acid (27) or arginine residue (28). Neither of these latter speculations was supported by any direct experimental evidence.…”
Section: The Chymotrypsinsmentioning
confidence: 99%
“…In addition, attention has been called to possible participation, in the catalytic process, of an aspartic acid (27) or arginine residue (28). Neither of these latter speculations was supported by any direct experimental evidence.…”
Section: The Chymotrypsinsmentioning
confidence: 99%
“…A relatively higher malonyl transferase activity in ACPs possessing arginine at the beginning of helix III stems from the ability of Arg to form diacyl derivatives at N o , N o0 , 30 which can carry out the transferase reaction at a much faster rate compared to that of ACPs containing a glutamine at this position. Also, the malonate moiety of malonyl-CoA can form a bidentate salt bridge with NH1 and NH2 of arginine, thereby stabilizing it in a much better fashion than glutamine, which perhaps explains faster rates observed for ACPs of its mutants with arginine at the beginning of the third helix of a given ACP.…”
Section: Discussionmentioning
confidence: 99%