A Possible Role for Calcitonin-Gene-Related Peptide in the Regulation of the Smooth Muscle Tone of the Bladder and Penis

Stief, Christian G.; Bénard, François; Bosch, Ruud; Aboseif, Sherif R.; Lue, Tom F.; Tanagho, Emil A.

doi:10.1016/s0022-5347(17)39972-x

Cited by 48 publications

(18 citation statements)

References 30 publications

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“…However, little is known about the effects of adenosine on penile erection. It has recently been observed that penile NANC neurotransmission is regulated by several endogenous substances such as calcitonin-gene-related peptide [3], vasoactive intestinal polypeptide [5], neuropeptide Y [6], substance P, prostaglandins and nitric oxide [4,[7][8][9]. In the present study, we demonstrated that exogenous adenosine and its analogues had relaxing effects on the corporeal smooth muscle submaximally contracted with noradrenaline as well as the inhibitory effects on transmural nerve stimulation induced contractions.…”

Section: Pharmacological Properties Of Adenosine Receptor Subtypessupporting

confidence: 66%

“…Many studies have shown that the main neurotransmitter mediating relaxation of corpus cavernosum smooth fibre is a non-adrenergic non-cholinergic (NANC) neurotransmitter [1][2][3][4][5][6][7]. Although several endogenous peptides, such as calcitonin-gene-related peptide [3], vasoactive intestinal polypeptide (VIP) [5], neuropeptide [6] and substance P, have been proposed as the NANC neurotransmitter, the main ones responsible for the penile erection are still under investigation.…”

Section: Introductionmentioning

confidence: 99%

“…Although several endogenous peptides, such as calcitonin-gene-related peptide [3], vasoactive intestinal polypeptide (VIP) [5], neuropeptide [6] and substance P, have been proposed as the NANC neurotransmitter, the main ones responsible for the penile erection are still under investigation. Recent studies [4,[7][8][9] have also shown that nitric oxide may be involved in the NANC neurotransmission that leads to the smooth muscle relaxation in the corpus cavernosum.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Adenosine modulation of neurotransmission in penile erection.

Chiang¹,

Wu²,

Tsai³

et al. 1994

Brit J Clinical Pharma

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Section: Pharmacological Properties Of Adenosine Receptor Subtypessupporting

confidence: 66%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Adenosine modulation of neurotransmission in penile erection.

Chiang¹,

Wu²,

Tsai³

et al. 1994

Brit J Clinical Pharma

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“…Therefore, NO donors are not widely used in the therapy of ED. Similarly inconsistent results were obtained with the intracavernosal administration of neurotransmitters that mediate their effect through an increase in the cAMP-mediated pathway, such as CGRP (20,21), VIP (22) and adenosine (23,24). Conversely, interesting results were obtained by blocking cAMP breakdown using a nonspeci®c inhibitor of PDE, such as papaverine.…”

Section: Clinical Results With Vasoactive Substances In Edmentioning

confidence: 98%

Erectile dysfunction: from biochemical pharmacology to advances in medical therapy

et al. 2000

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Research on penile smooth muscle physiology has increased the number of drugs available for treating erectile dysfunction (ED). Penile erection involves the relaxation of smooth muscle in the corpus cavernosum. The key mediator of smooth muscle relaxation is nitric oxide (NO), which acts by increasing the cellular level of cGMP. Another cyclic nucleotide, cAMP, is involved in smooth muscle cell relaxation; cAMP formation is stimulated by a number of compounds, such as alprostadil. An increase in cAMP and/or cGMP levels can also be induced by inhibition of phosphodiesterases (PDEs), the enzymes involved in cyclic nucleotide breakdown. Both papaverine and sildena®l are PDE inhibitors. Papaverine is a non-speci®c inhibitor of these enzymes; sildena®l is an orally active, potent and selective inhibitor of GMP-speci®c PDE5, the predominant isoenzyme metabolizing cGMP in the cells of the corpus cavernosum. Penile smooth muscle contraction, induced by adrenergic ®bers through a 1 adrenoceptors, produces detumescence, thus making a adrenoceptor antagonists suitable for maintenance of penile erection. The orally active drug yohimbine is a mixed a 1 -a 2 adrenoceptor antagonist that works by a dual mechanism; it facilitates sexual arousal by acting on a 2 adrenoceptors in the central nervous system and blocks adrenergic in¯uences at peripheral level.

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“…Various studies revealed that both calcitonin gene related peptide (CGRP) 7 and vasoactive intestinal polypeptide (VIP) 8 could be found in NANC nerve terminals and act as the NANC neurotransmitter substance. However, based on ®ndings that the effects of these substances could not completely account for erections the search continued for other substances.…”

Section: Penile Control Systemsmentioning

confidence: 99%

Vascular control mechanisms in penile erection: phylogeny and the inevitability of multiple and overlapping systems

Adams

et al. 1997

Int J Impot Res

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A co-ordinated series of vascular events underlie the generation of a penile erection. The control and regulation of this simple event is, in fact, a complex of interactions occurring at multiple levels. Many of these individual pathways and responses have been studied extensively. The understanding of the necessity for the integration between the individual pathways into a complex of series and parallel coupled mechanisms provides a rationale for the development of a framework of multiple and overlapping systems. This paper sets out some of the principles of integrated and balanced control of vasodilation and vasoconstriction in the penis. In addition, the role of growth induction and regression and the importance of time as a factor in studying penile structure and function is discussed.

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A Possible Role for Calcitonin-Gene-Related Peptide in the Regulation of the Smooth Muscle Tone of the Bladder and Penis

Cited by 48 publications

References 30 publications

Adenosine modulation of neurotransmission in penile erection.

Adenosine modulation of neurotransmission in penile erection.

Erectile dysfunction: from biochemical pharmacology to advances in medical therapy

Vascular control mechanisms in penile erection: phylogeny and the inevitability of multiple and overlapping systems

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