A Postpartum Model in Rat: Behavioral and Gene Expression Changes Induced by Ovarian Steroid Deprivation

Suda, Shiro; Segi-Nishida, Eri; Newton, Samuel S.; Duman, Ronald S.

doi:10.1016/j.biopsych.2008.03.029

Cited by 137 publications

(125 citation statements)

References 70 publications

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“…Furthermore, estradiol administration has been shown to increase synaptic plasticity and dendritic spine density within the hippocampus (ter Horst, 2010), whereas withdrawal from pregnancy levels of estradiol results in decreased hippocampal BDNF expression (Suda et al, 2008) and suppressed hippocampal neurogenesis (Green and Galea, 2008). Finally, high as compared with low E2 doses may inhibit neurogenesis in the dentate gyrus (Tanaka and Sokabe, 2013), suggesting that PPD-associated estrogen sensitivity may have deleterious consequences on mood in at-risk women.…”

Section: Discussionmentioning

confidence: 99%

Replication of Epigenetic Postpartum Depression Biomarkers and Variation with Hormone Levels

Osborne

Clive

Kimmel

et al. 2015

Neuropsychopharmacol

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DNA methylation variation at HP1BP3 and TTC9B is modified by estrogen exposure in the rodent hippocampus and was previously shown to be prospectively predictive of postpartum depression (PPD) when modeled in antenatal blood. The objective of this study was to replicate the predictive efficacy of the previously established model in women with and without a previous psychiatric diagnosis and to understand the effects of changing hormone levels on PPD biomarker loci. Using a statistical model trained on DNA methylation data from N = 51 high-risk women, we prospectively predicted PPD status in an independent N = 51 women using first trimester antenatal gene expression levels of HP1BP3 and TTC9B, with an area under the receiver operator characteristic curve (AUC) of 0.81 (95% CI: 0.69-0.92, po5 × 10 − 4 ). Modeling DNA methylation of these genes in N = 240 women without a previous psychiatric diagnosis resulted in a cross-sectional prediction of PPD status with an AUC of 0.81 (95% CI: 0.68-0.93, p = 0.01). TTC9B and HP1BP3 DNA methylation at early antenatal time points showed moderate evidence for association to the change in estradiol and allopregnanolone over the course of pregnancy, suggesting that epigenetic variation at these loci may be important for mediating hormonal sensitivity. In addition both loci showed PPD-specific trajectories with age, possibly mediated by age-associated hormonal changes. The data add to the growing body of evidence suggesting that PPD is mediated by differential gene expression and epigenetic sensitivity to pregnancy hormones and that modeling proxies of this sensitivity enable accurate prediction of PPD.

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Section: Discussionmentioning

confidence: 99%

Replication of Epigenetic Postpartum Depression Biomarkers and Variation with Hormone Levels

Osborne

Clive

Kimmel

et al. 2015

Neuropsychopharmacol

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“…Results, however, seem to be unsupportive of the notion that these quick hormonal changes impact PPD (as reviewed by Zonana & Gorman, 2005). In fact, research has been moving away from a focus on these two hormones, and instead is considering either how these hormones affect other biological processes in the body (e.g., stress-hormone levels, Suda et al, 2008), or other processes and/or chemicals all together (e.g., allopregnanlone, Zonana & Gorman;cortical-releasing-hormone, Rich-Edwards et al, 2008;and oxytocin, Consiglio, 2006).…”

Section: Causal Theoriesmentioning

confidence: 99%

“…The most common statistic reported for MPPD is approximately 10-15% (e.g., American Psychological Association, 2007;Bina, 2008;CPA, 2009;Posmontier & Horowitz, 2004;Rychnovksy & Beck, 2006) and 10% for PPPD (e.g., Paulson & Bazemore, 2010). The following is a compiled list of symptoms from a number of sources (e.g., APA, 2000; Knudson-Martin & Silverstein, 2009;Letourneau et al, 2010;Nicolson, 1990;Roehrich, 2008;Suda et al, 2008;Whiffen, 1992) that fathers and mothers may experience after childbirth: mood swings, guilt, shame, suicidal ideation, energy loss, loss of interest, agitation, motor retardation, anxiety, irritability, and/or insomnia.…”

mentioning

confidence: 99%

Constructions of motherhood and fatherhood in newspaper articles on maternal and paternal postpartum depression

Alexander

McMullen

2015

GENL

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Postpartum depression (PPD) is a medicalized condition that exists on a continuum of postpartum mood disorders. PPD is reported to be experienced by 10-15% of mothers and 10% of fathers during pregnancy or after the birth of a baby. PPD, as experienced by either parent, is considered a serious condition because of its potential short-and long-term negative impacts on the developing child.In this thesis I explore how motherhood and fatherhood are constructed in the context of articles on maternal and paternal PPD in Canadian and American newspapers. Specifically, Ifocus on how references to the opposite partner were used to position each parent, and how each parent was positioned with respect to the new baby.In the articles on maternal PPD, husbands were either inconsequential to the story, positioned as being absent, or constructed as supporting the mother through instrumental and action-oriented behaviours. In addition, mothers were constructed as lonely and isolated because of self-imposed limitations (e.g., feeling ashamed for not being happy).In the articles on paternal PPD, the mother-father relationship was based on differences and competition. Fathers were constructed as isolated, lonely and misunderstood, most often through mother-blaming, such as by positioning the mother as responsible for the father's wellbeing (e.g., causing his PPD), and by labelling PPD "a woman's domain." Fathers' loneliness was presented as being due to imposed limitations of others (e.g., others did not properly prepare fathers for fatherhood).Mothering was constructed as being instinctually skilled, tolerant, and self-sacrificing, with the inherent capability to manage multiple roles and changes. The mother-baby relationship was constructed as naturally joyful, all-important and -consuming. Fathers were not expected to be as skilled or instinctively prepared and tolerant, to engage in chores/childcare, or to be explicitly overjoyed with the baby. Mothers were blamed for their distress in the role, while others were blamed for fathers' distresses.Gendered stereotypes in the parenting role were perpetuated in these newspaper articles.Parenthood was not constructed as a collaboration, but rather motherhood and fatherhood stood in isolation from each other, with motherhood positioned as the primary role. These constructions continue to maintain fathers in the background of parenthood as an "other," and to position mothers as responsible for the well-being of her partner, child(ren) and herself.iv Acknowledgements First and foremost, I recognize that I probably would not be here if it was not for the upbringing and unconditional support of my mom (Anna), dad (Steve) and sister (Catherine).My other half, Ben, was also a blessed angel who kept me grounded and sane! All of them kept me going, not only with their encouragement, but also with their excitement.

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“…Ezen megállapítások alapján a terhesség utáni depresszió egy hormonmegvont állapottal jár együtt, ami feltételezi, hogy a női nemi hormonok drasztikus csökkenése áll a szülés utáni időszak depressziós tüneteinek hátterében (Parry et al, 2003;Steiner et al, 2003;Douma et al, 2005). Ezt a megállapítást humán vizsgálatokban (Bloch et al, 2000(Bloch et al, , 2003 és állatmodelleken (Galea et al, 2001;Stoffel & Craft, 2004;Suda et al, 2008) is igazolták. Érdekes módon több klinikai vizsgálat eredményei is azt sugallták, hogy a hormonális változások csak az arra érzékeny nőknél idéztek elő depressziós tüneteket (Heidrich et al, 1994;Klier et al, 2007).…”

Section: A Terhesség Utáni (Posztpartum) Depresszióunclassified

“…Suda és munkatársai továbbgondolták a posztpartum depresszió hormonmegvonásos modelljét (Suda et al, 2008), és a progeszteron hatására helyezték a hangsúlyt. Ez a lépés kritikus lehet egy megfelelő PPD-modell kialakításához, mivel a progeszteron hatással van mind a stresszválaszra, mind az idegsejtek serkenthetőségére (Bitran & Dowd, 1996;Brunton et al, 2009).…”

Section: A Posztpartum Modellunclassified

Agykérgi szinapszisok összehasonlító vizsgálata és a szinapszisszám változása posztpartum depresszióban

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A Postpartum Model in Rat: Behavioral and Gene Expression Changes Induced by Ovarian Steroid Deprivation

Cited by 137 publications

References 70 publications

Replication of Epigenetic Postpartum Depression Biomarkers and Variation with Hormone Levels

Replication of Epigenetic Postpartum Depression Biomarkers and Variation with Hormone Levels

Constructions of motherhood and fatherhood in newspaper articles on maternal and paternal postpartum depression

Agykérgi szinapszisok összehasonlító vizsgálata és a szinapszisszám változása posztpartum depresszióban

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