A potent pressor response elicited by drinking water

Jordan, Jens; Shannon, J. R.; Grogan, Eric L.; Biaggioni, Italo; Robertson, David

doi:10.1016/s0140-6736(99)99015-3

Cited by 189 publications

(178 citation statements)

References 4 publications

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“…We showed that drinking 480 mL water increased seated blood pressure 43 mm Hg in patients with autonomic failure and 11 mm Hg in older control subjects. 3 This finding prompted us to further investigate the short-term effect of water drinking on blood pressure in patients with autonomic failure and in young and older normal controls. Furthermore, we endeavored to define the mechanism or mechanisms that could contribute to the pressor effect with water drinking.…”

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confidence: 99%

The Pressor Response to Water Drinking in Humans

Jordan¹,

Shannon²,

Black³

et al. 2000

Circulation

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328

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Background-Water drinking increases blood pressure profoundly in patients with autonomic failure and substantially in older control subjects. The mechanism that mediates this response is not known. Methods and Results-We studied the effect of drinking tap water on seated blood pressure in 47 patients with severe autonomic failure (28 multiple system atrophy [MSA], 19 pure autonomic failure patients [PAF]). Eleven older controls and 8 young controls served as control group. We also studied the mechanisms that could increase blood pressure with water drinking. Systolic blood pressure increased profoundly with water drinking, reaching a maximum of 33Ϯ5 mm Hg in MSA and 37Ϯ7 in PAF mm Hg after 30 to 35 minutes. The pressor response was greater in patients with more retained sympathetic function and was almost completely abolished by trimethaphan infusion. Systolic blood pressure increased by 11Ϯ2.4 mm Hg in elderly but not in young controls. Plasma norepinephrine increased in both groups. Plasma renin activity, vasopressin, and blood volume did not change in any group. Conclusions-Water drinking significantly and rapidly raises sympathetic activity. Indeed, it raises plasma norepinephrine as much as such classic sympathetic stimuli as caffeine and nicotine. This effect profoundly increases blood pressure in autonomic failure patients, and this effect can be exploited to improve symptoms due to orthostatic hypotension. Water drinking also acutely raises blood pressure in older normal subjects. The pressor effect of oral water is an important yet unrecognized confounding factor in clinical studies of pressor agents and antihypertensive medications.

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confidence: 99%

The Pressor Response to Water Drinking in Humans

Jordan¹,

Shannon²,

Black³

et al. 2000

Circulation

Self Cite

328

454

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“…In addition, previous studies showed that water drinking has had an important impact on the management of autonomic nervous system disorders. [10][11][12][13][14]29 Water drinking delays presyncope with orthostatic stress in healthy young subjects and in patients with neurally mediated syncope, and decreased syncope risk during blood donations-related vasovagal reactions. 13,14,36 Furthermore, water drinking attenuates postprandial hypotension.…”

Section: Discussionmentioning

confidence: 99%

“…[10][11][12] Also, oral water intake has an acute effect on BP even in normal subjects, although the effects are more subtle. 11,13 Although the exact mechanism that causes this pressor response has not been precisely elucidated, it is likely to involve vasoconstriction via water-induced sympathetic activation.…”

Section: Introductionmentioning

confidence: 99%

Acute effect of oral water intake during exercise on post-exercise hypotension

et al. 2012

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BACKGROUND/OBJECTIVES: Post-exercise hypotension (PEH) is a sustained reduction in mean arterial blood pressure (MAP) after prolonged exercise. As water drinking is known to elicit a large acute pressor response, we aimed to explore the effect of drinking water during exercise on PEH. SUBJECTS/METHODS: Ten normotensive male volunteers performed the control protocol: 30 min supine rest, 60 min cycling exercise in moderate intensity, and 60 min supine rest recovery. In the water drinking protocol, the same procedure was followed but with water intake during exercise to compensate for exercise-induced body weight lost. Heart rate, MAP, cardiac output and blood flow in the brachial artery were measured pre-and post-exercise. The total vascular conductance (TVC) and the vascular conductance (VC) in the brachial artery were calculated pre-and post-exercise, and the relative change in plasma volume (DPV) was also measured. RESULTS: Body weight loss during exercise was 0.65±0.24 kg in the control. DPV was not different during recovery in either protocol. MAP in the control was significantly reduced during the latter half of the recovery compared with baseline. In contrast, MAP in the water drinking showed no reduction during recovery, and was significantly higher than in the control. TVC and VC in the brachial artery were lower in the water drinking, in which vasoconstriction was relatively exaggerated. CONCLUSIONS: Prevention of dehydration after exercise by oral water intake, or oral water intake per se has a role in maintaining post-exercise MAP and it may be related to reduction in TVC.

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“…в течение часа, а иногда значитель-но усиливает вазопрессорный эффект других препа-ратов [64]. Также прибегают к увеличению потреб-ления соли (не менее 10 г в день) и жидкости (более 2 л в день) [61,[64][65][66][67].…”

Section: лечение ог при дтлunclassified

Orthostatic hypotension in dementia with Lewy bodies

Чимагомедова¹,

Левин²

2016

Z. nevrol. psikhiatr. im. S.S. Korsakova

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ГБОУ ДПО «Российская медицинская академия последипломного образования», Москва, Россия В обзоре рассматриваются особенности проявления ортостатической гипотензии при деменции с тельцами Леви и методы ее диагностики. Ранняя диагностика данных нарушений позволит предотвратить такие нежелательные последствия, как падения и обмороки, улучшить повседневную деятельность и повысить качество жизни пациентов. анализируются современные подходы к коррекции данного состояния. The features of orthostatic hypotension in patients with dementia with Lewy bodies are considered. The early diagnosis of these disorders could prevent adverse conditions (falls and syncopes), improve activities of daily living and quality-of-life. Current approaches to treatment of orthostatic hypotension are analyzed.

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A potent pressor response elicited by drinking water

Cited by 189 publications

References 4 publications

The Pressor Response to Water Drinking in Humans

The Pressor Response to Water Drinking in Humans

Acute effect of oral water intake during exercise on post-exercise hypotension

Orthostatic hypotension in dementia with Lewy bodies

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